Disulfide-linked high molecular weight protein associated with human cataract
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Cataract-linked γD-crystallin mutants have weak affinity to lens chaperones α-crystallinsModifications of human betaA1/betaA3-crystallins include S-methylation, glutathiolation, and truncationProtein homeostasis: live long, won't prosperUltraviolet radiation and the eye: an epidemiologic study.Identification of amino acid epimerization and isomerization in crystallin proteins by tandem LC-MSAggregation of lens crystallins in an in vivo hyperbaric oxygen guinea pig model of nuclear cataract: dynamic light-scattering and HPLC analysis.Role of pirenoxine in the effects of catalin on in vitro ultraviolet-induced lens protein turbidity and selenite-induced cataractogenesis in vivo.Glutaredoxin 2 (Grx2) gene deletion induces early onset of age-dependent cataracts in miceLoss of thiol repair systems in human cataractous lenses.N-terminal truncated UCH-L1 prevents Parkinson's disease associated damage.Homozygous mutations in PXDN cause congenital cataract, corneal opacity, and developmental glaucomaLens transglutaminase and cataract formationBiochemical evidence for membrane disintegration in human cataractsNondisulfide polymerization of gamma- and beta-crystallins in the human lens.Selective oxidation of cysteine and methionine in normal and senile cataractous lenses.A rapid, comprehensive liquid chromatography-mass spectrometry (LC-MS)-based survey of the Asp isomers in crystallins from human cataract lensesEvidence of Highly Conserved β-Crystallin Disulfidome that Can be Mimicked by In Vitro Oxidation in Age-related Human Cataract and Glutathione Depleted Mouse LensAnalysis of nuclear fiber cell cytoplasmic texture in advanced cataractous lenses from Indian subjects using Debye-Bueche theory.Oxidative stress, lens gap junctions, and cataractsSuppression of phase separation in solutions of bovine gamma IV-crystallin by polar modification of the sulfur-containing amino acids.Racemization in human lens: evidence of rapid insolubilization of specific polypeptides in cataract formation.High correlation between pentosidine protein crosslinks and pigmentation implicates ascorbate oxidation in human lens senescence and cataractogenesis.An Internal Disulfide Locks a Misfolded Aggregation-prone Intermediate in Cataract-linked Mutants of Human γD-Crystallin.Molecular mechanism of cataractogenesis: III. Toxic metabolites of oxygen as initiators of lipid peroxidation and cataract.Self-assembly of protein aggregates in ageing disorders: the lens and cataract model.Quantitative assessment of DNA damage directly in lens epithelial cells from senile cataract patientsPotentiation of intraocular absorption and drug metabolism of N-acetylcarnosine lubricant eye drops: drug interaction with sight threatening lipid peroxides in the treatment for age-related eye diseases.Levels of crystallin fragments and identification of their origin in water soluble high molecular weight (HMW) proteins of human lenses.Patterns in effects of sulfhydryl reagents on transport in bovine lens.Dynamic disulfide exchange in a crystallin protein in the human eye lens promotes cataract-associated aggregation
P2860
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P2860
Disulfide-linked high molecular weight protein associated with human cataract
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on July 1978
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Disulfide-linked high molecular weight protein associated with human cataract
@en
Disulfide-linked high molecular weight protein associated with human cataract.
@nl
type
label
Disulfide-linked high molecular weight protein associated with human cataract
@en
Disulfide-linked high molecular weight protein associated with human cataract.
@nl
prefLabel
Disulfide-linked high molecular weight protein associated with human cataract
@en
Disulfide-linked high molecular weight protein associated with human cataract.
@nl
P2860
P356
P1476
Disulfide-linked high molecular weight protein associated with human cataract
@en
P2860
P304
P356
10.1073/PNAS.75.7.3244
P407
P577
1978-07-01T00:00:00Z