Antigen-independent memory CD8 T cells do not develop during chronic viral infection.
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Analysis of CD127 and KLRG1 expression on hepatitis C virus-specific CD8+ T cells reveals the existence of different memory T-cell subsets in the peripheral blood and liverMolecular and cellular insights into T cell exhaustionTissue-resident memory T cellsOvercoming T cell exhaustion in infection and cancerT cell memory in the context of persistent herpes viral infectionsLiver-Infiltrating Lymphocytes in Chronic Human Hepatitis C Virus Infection Display an Exhausted Phenotype with High Levels of PD-1 and Low Levels of CD127 ExpressionViral Vaccines and CTL ResponseThe PD1:PD-L1/2 Pathway from Discovery to Clinical ImplementationInnate and Adaptive Immune Regulation During Chronic Viral InfectionsBlimp-1 homolog Hobit identifies effector-type lymphocytes in humansHost-reactive CD8+ memory stem cells in graft-versus-host diseaseRestoring function in exhausted CD8 T cells during chronic viral infectionEffector memory Th1 CD4 T cells are maintained in a mouse model of chronic malariaLysine auxotrophy combined with deletion of the SecA2 gene results in a safe and highly immunogenic candidate live attenuated vaccine for tuberculosisAntigen load and viral sequence diversification determine the functional profile of HIV-1-specific CD8+ T cellsHLA Class I-T cell epitopes from trans-sialidase proteins reveal functionally distinct subsets of CD8+ T cells in chronic Chagas disease.Changes in Trypanosoma cruzi-specific immune responses after treatment: surrogate markers of treatment efficacy.Delayed expansion and contraction of CD8+ T cell response during infection with virulent Salmonella typhimurium.De novo recruitment of antigen-experienced and naive T cells contributes to the long-term maintenance of antiviral T cell populations in the persistently infected central nervous systemInduction of protective immunity against murine gammaherpesvirus 68 infection in the absence of viral latency.Memory CD8+ T cell differentiationPersistent expression of FLAG-tagged micro dystrophin in nonhuman primates following intramuscular and vascular delivery.Cutting edge: IL-7-independent regulation of IL-7 receptor alpha expression and memory CD8 T cell development.Shaping successful and unsuccessful CD8 T cell responses following infection.Aberrant plasma IL-7 and soluble IL-7 receptor levels indicate impaired T-cell response to IL-7 in human tuberculosis.Dynamics of viral evolution and CTL responses in HIV-1 infectionEpigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade.Limited transplantation of antigen-expressing hematopoietic stem cells induces long-lasting cytotoxic T cell responsesLow CD8 T-cell proliferative potential and high viral load limit the effectiveness of therapeutic vaccination.Augmented replicative capacity of the boosting antigen improves the protective efficacy of heterologous prime-boost vaccine regimens.Altered T cell memory and effector cell development in chronic lymphatic filarial infection that is independent of persistent parasite antigen.Intrinsic functional dysregulation of CD4 T cells occurs rapidly following persistent viral infectionFeatures of responding T cells in cancer and chronic infection.Identification of stem cell transcriptional programs normally expressed in embryonic and neural stem cells in alloreactive CD8+ T cells mediating graft-versus-host diseaseExhausted CD8 T cells downregulate the IL-18 receptor and become unresponsive to inflammatory cytokines and bacterial co-infections.Non-hematopoietic cells in lymph nodes drive memory CD8 T cell inflation during murine cytomegalovirus infection.Chronic antigen stimulation alone is sufficient to drive CD8+ T cell exhaustionTumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impairedT-cell exhaustion: characteristics, causes and conversion.Pronounced virus-dependent activation drives exhaustion but sustains IFN-γ transcript levels.
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Antigen-independent memory CD8 T cells do not develop during chronic viral infection.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 25 October 2004
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Antigen-independent memory CD8 T cells do not develop during chronic viral infection.
@en
Antigen-independent memory CD8 T cells do not develop during chronic viral infection.
@nl
type
label
Antigen-independent memory CD8 T cells do not develop during chronic viral infection.
@en
Antigen-independent memory CD8 T cells do not develop during chronic viral infection.
@nl
prefLabel
Antigen-independent memory CD8 T cells do not develop during chronic viral infection.
@en
Antigen-independent memory CD8 T cells do not develop during chronic viral infection.
@nl
P2093
P2860
P356
P1476
Antigen-independent memory CD8 T cells do not develop during chronic viral infection.
@en
P2093
Daniel L Barber
E John Wherry
Joseph N Blattman
Rafi Ahmed
Susan M Kaech
P2860
P304
16004-16009
P356
10.1073/PNAS.0407192101
P407
P577
2004-10-25T00:00:00Z