Imatinib mesylate inhibits the profibrogenic activity of TGF-beta and prevents bleomycin-mediated lung fibrosis. - Wikidata - wikimedia - TriplyDB

Imatinib mesylate inhibits the profibrogenic activity of TGF-beta and prevents bleomycin-mediated lung fibrosis.

Imatinib mesylate inhibits the profibrogenic activity of TGF-beta and prevents bleomycin-mediated lung fibrosis.

http://www.wikidata.org/entity/Q37591872

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Reactive oxygen species-mediated p38 MAPK regulates carbon nanotube-induced fibrogenic and angiogenic responses Bone morphogenetic protein-4 inhibitor gremlin is overexpressed in idiopathic pulmonary fibrosis Immunotherapy of systemic sclerosis Cellular and molecular mechanisms of fibrosis Inhibition of transforming growth factor-beta1-induced signaling and epithelial-to-mesenchymal transition by the Smad-binding peptide aptamer Trx-SARA Bone marrow fibrosis in primary myelofibrosis: pathogenic mechanisms and the role of TGF-β New Insight into the Anti-liver Fibrosis Effect of Multitargeted Tyrosine Kinase Inhibitors: From Molecular Target to Clinical Trials Critical role of actin-associated proteins in smooth muscle contraction, cell proliferation, airway hyperresponsiveness and airway remodeling Nintedanib: evidence for its therapeutic potential in idiopathic pulmonary fibrosis Pharmacology and rationale for imatinib in the treatment of scleroderma Fibrotic and sclerotic manifestations of chronic graft-versus-host disease Cell density sensing alters TGF-β signaling in a cell-type-specific manner, independent from Hippo pathway activation Structural Mechanisms Determining Inhibition of the Collagen Receptor DDR1 by Selective and Multi-Targeted Type II Kinase Inhibitors Active transforming growth factor-β is associated with phenotypic changes in granulomas after drug treatment in pulmonary tuberculosis Imatinib treatment causes substantial transcriptional changes in adult Schistosoma mansoni in vitro exhibiting pleiotropic effects Noncanonical TGF-beta pathways, mTORC1 and Abl, in renal interstitial fibrogenesis Nf1+/- mast cells induce neurofibroma like phenotypes through secreted TGF-beta signaling Non-Smad pathways in TGF-beta signaling TGF-beta-RI kinase inhibitor SD-208 reduces the development and progression of melanoma bone metastases Platelet-derived growth factor signaling through ephrin-b2 regulates hepatic vascular structure and function.Neuropilin-1 promotes cirrhosis of the rodent and human liver by enhancing PDGF/TGF-beta signaling in hepatic stellate cells.Abl kinase inhibits the engulfment of apoptotic [corrected] cells in Caenorhabditis elegans A non-Smad mechanism of fibroblast activation by transforming growth factor-beta via c-Abl and Egr-1: selective modulation by imatinib mesylate.Late treatment with imatinib mesylate ameliorates radiation-induced lung fibrosis in a mouse model Activated Abl kinase inhibits oncogenic transforming growth factor-beta signaling and tumorigenesis in mammary tumors.Fibrosis of two: Epithelial cell-fibroblast interactions in pulmonary fibrosis Use of senescence-accelerated mouse model in bleomycin-induced lung injury suggests that bone marrow-derived cells can alter the outcome of lung injury in aged mice.Innovative approaches to the therapy of fibrosis Transforming growth factor-β (TGF-β) expression is increased in the subsynovial connective tissues of patients with idiopathic carpal tunnel syndrome.Systemic Sclerosis-Associated Interstitial Lung Disease: Lessons from Clinical Trials, Outcome Measures, and Future Study Design.Tyrosine kinases in inflammatory dermatologic disease.Endocytosis of collagen by hepatic stellate cells regulates extracellular matrix dynamics.Fra-1/AP-1 transcription factor negatively regulates pulmonary fibrosis in vivo.Quantitative microtiter fibronectin fibrillogenesis assay: use in high throughput screening for identification of inhibitor compounds.Low-dose oral imatinib in the treatment of systemic sclerosis interstitial lung disease unresponsive to cyclophosphamide: a phase II pilot study.Medical therapy of stricturing Crohn's disease: what the gut can learn from other organs - a systematic review.IL-33 promotes ST2-dependent lung fibrosis by the induction of alternatively activated macrophages and innate lymphoid cells in mice Signal transduction pathway analysis in fibromatosis: receptor and nonreceptor tyrosine kinases.Effects of imatinib mesylate on pulmonary allergic vasculitis in a murine model Novel therapeutic approaches for pulmonary fibrosis.

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Imatinib mesylate inhibits the profibrogenic activity of TGF-beta and prevents bleomycin-mediated lung fibrosis.

http://www.wikidata.org/entity/Q37591872

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2004 nî lūn-bûn

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Imatinib mesylate inhibits the ...... omycin-mediated lung fibrosis.

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Imatinib mesylate inhibits the ...... omycin-mediated lung fibrosis.

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Imatinib mesylate inhibits the ...... omycin-mediated lung fibrosis.

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Imatinib mesylate inhibits the ...... omycin-mediated lung fibrosis.

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Imatinib mesylate inhibits the ...... omycin-mediated lung fibrosis.

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Imatinib mesylate inhibits the ...... omycin-mediated lung fibrosis.

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Andrew H Limper

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Craig E Daniels

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Edward B Leof

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Mark C Wilkes

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Maryanne Edens

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Stephen J Murphy

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Ted J Kottom

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P2860

The amphiphysin-like protein 1 (ALP1) interacts functionally with the cABL tyrosine kinase and may play a role in cytoskeletal regulation

The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis

Role of transforming growth factor beta in human disease

Cell-type-specific activation of PAK2 by transforming growth factor beta independent of Smad2 and Smad3

Idiopathic pulmonary fibrosis: prevailing and evolving hypotheses about its pathogenesis and implications for therapy

The Abl family kinases: mechanisms of regulation and signaling

Transforming growth factor beta in tissue fibrosis

Prognostic significance of histopathologic subsets in idiopathic pulmonary fibrosis

Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicates defects of epithelial-mesenchymal interaction

Interstitial fibrosis and growth factors

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