5S ribosomal RNA is an essential component of a nascent ribosomal precursor complex that regulates the Hdm2-p53 checkpoint.
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The importance of ribosome production, and the 5S RNP-MDM2 pathway, in health and diseaseTargeted cancer therapy with ribosome biogenesis inhibitors: a real possibility?Structure of human MDM2 complexed with RPL11 reveals the molecular basis of p53 activationArchitecture of the Rix1-Rea1 checkpoint machinery during pre-60S-ribosome remodelingRole of ribosomal protein mutations in tumor development (Review)Transcription by RNA polymerase III: insights into mechanism and regulationRegulatory Roles of Rpl22 in Hematopoiesis: An Old Dog with New TricksYeast Kre33 and human NAT10 are conserved 18S rRNA cytosine acetyltransferases that modify tRNAs assisted by the adaptor Tan1/THUMPD1Systems biology analysis reveals role of MDM2 in diabetic nephropathyThe 5S RNP couples p53 homeostasis to ribosome biogenesis and nucleolar stressNucleolar stress induces ubiquitination-independent proteasomal degradation of PICT1 proteinPICT-1 is a key nucleolar sensor in DNA damage response signaling that regulates apoptosis through the RPL11-MDM2-p53 pathwayNucleolar stress with and without p53.Marrow failure: a window into ribosome biologyRibosomal proteins and human diseases: pathogenesis, molecular mechanisms, and therapeutic implicationsRibosomopathies: mechanisms of disease.Ribosomal proteins: functions beyond the ribosomeInvolvement of human ribosomal proteins in nucleolar structure and p53-dependent nucleolar stressThe roles of RRP15 in nucleolar formation, ribosome biogenesis and checkpoint control in human cells.Chaperoning 5S RNA assembly.Transcriptome analysis reveals a ribosome constituents disorder involved in the RPL5 downregulated zebrafish model of Diamond-Blackfan anemia.The NF45/NF90 Heterodimer Contributes to the Biogenesis of 60S Ribosomal Subunits and Influences Nucleolar Morphology.The RNA recognition motif of NIFK is required for rRNA maturation during cell cycle progression.Ribosome biogenesis dysfunction leads to p53-mediated apoptosis and goblet cell differentiation of mouse intestinal stem/progenitor cellsSUMO regulates p21Cip1 intracellular distribution and with p21Cip1 facilitates multiprotein complex formation in the nucleolus upon DNA damageEffect of low doses of actinomycin D on neuroblastoma cell linesA liaison between mTOR signaling, ribosome biogenesis and cancerCurrent insights into the diagnosis and treatment of inherited bone marrow failure syndromes in China.Glucocorticoids improve erythroid progenitor maintenance and dampen Trp53 response in a mouse model of Diamond-Blackfan anaemia.Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesisHuman AATF/Che-1 forms a nucleolar protein complex with NGDN and NOL10 required for 40S ribosomal subunit synthesis.The human box C/D snoRNAs U3 and U8 are required for pre-rRNA processing and tumorigenesis.Back to bases: how a nucleotide biosynthetic enzyme controls p53 activation.Deletion of ribosomal protein genes is a common vulnerability in human cancer, especially in concert with TP53 mutations.Diamond Blackfan anemia: a model for the translational approach to understanding human disease.p53 and ribosome biogenesis stress: the essentials.Role of the nucleus in apoptosis: signaling and execution.Adenovirus siMDM2 and NDRG2 Gene Therapy Inhibits Cell Proliferation and Induces Apoptosis of Squamous Cell Carcinoma.Down-regulation of 5S rRNA by miR-150 and miR-383 enhances c-Myc-rpL11 interaction and inhibits proliferation of esophageal squamous carcinoma cells.Gradual reduction in rRNA transcription triggers p53 acetylation and apoptosis via MYBBP1A.
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5S ribosomal RNA is an essential component of a nascent ribosomal precursor complex that regulates the Hdm2-p53 checkpoint.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 03 July 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
5S ribosomal RNA is an essenti ...... lates the Hdm2-p53 checkpoint.
@en
5S ribosomal RNA is an essenti ...... lates the Hdm2-p53 checkpoint.
@nl
type
label
5S ribosomal RNA is an essenti ...... lates the Hdm2-p53 checkpoint.
@en
5S ribosomal RNA is an essenti ...... lates the Hdm2-p53 checkpoint.
@nl
prefLabel
5S ribosomal RNA is an essenti ...... lates the Hdm2-p53 checkpoint.
@en
5S ribosomal RNA is an essenti ...... lates the Hdm2-p53 checkpoint.
@nl
P2093
P2860
P1433
P1476
5S ribosomal RNA is an essenti ...... lates the Hdm2-p53 checkpoint.
@en
P2093
George Thomas
Giulio Donati
Suresh Peddigari
P2860
P356
10.1016/J.CELREP.2013.05.045
P577
2013-07-03T00:00:00Z