A dual-targeting triplebody mediates preferential redirected lysis of antigen double-positive over single-positive leukemic cells.
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NK Cell-Mediated Antibody-Dependent Cellular Cytotoxicity in Cancer ImmunotherapyT cell-recruiting triplebody 19-3-19 mediates serial lysis of malignant B-lymphoid cells by a single T cellNK cells from an AML patient have recovered in remission and reached comparable cytolytic activity to that of a healthy monozygotic twin mediated by the single-chain triplebody SPM-2.Efficient targeting of CD13 on cancer cells by the immunotoxin scFv13-ETA' and the bispecific scFv [13xds16].Mono- and dual-targeting triplebodies activate natural killer cells and have anti-tumor activity in vitro and in vivo against chronic lymphocytic leukemia.Chip-based platform for dynamic analysis of NK cell cytolysis mediated by a triplebody.Heterodimeric Bispecific Single Chain Variable Fragments (scFv) Killer Engagers (BiKEs) Enhance NK-cell Activity Against CD133+ Colorectal Cancer Cells.Enhanced tumor-targeting selectivity by modulating bispecific antibody binding affinity and format valence.Dual-targeting triplebody 33-3-19 mediates selective lysis of biphenotypic CD19+ CD33+ leukemia cells.Dual-targeting triplebody 33-16-123 (SPM-2) mediates effective redirected lysis of primary blasts from patients with a broad range of AML subtypes in combination with natural killer cells
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A dual-targeting triplebody mediates preferential redirected lysis of antigen double-positive over single-positive leukemic cells.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on January 2014
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
A dual-targeting triplebody me ...... ingle-positive leukemic cells.
@en
A dual-targeting triplebody me ...... ingle-positive leukemic cells.
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type
label
A dual-targeting triplebody me ...... ingle-positive leukemic cells.
@en
A dual-targeting triplebody me ...... ingle-positive leukemic cells.
@nl
prefLabel
A dual-targeting triplebody me ...... ingle-positive leukemic cells.
@en
A dual-targeting triplebody me ...... ingle-positive leukemic cells.
@nl
P2093
P2860
P356
P1476
A dual-targeting triplebody me ...... ingle-positive leukemic cells.
@en
P2093
Andreas Mackensen
Domenica Saul
Fuat S Oduncu
Georg H Fey
Ingo Schubert
Stefanie Nowecki
P2860
P304
P356
10.4161/MABS.26768
P577
2014-01-01T00:00:00Z