Cleavages within the prodomain direct intracellular trafficking and degradation of mature bone morphogenetic protein-4. - Wikidata - wikimedia - TriplyDB

Cleavages within the prodomain direct intracellular trafficking and degradation of mature bone morphogenetic protein-4.

Cleavages within the prodomain direct intracellular trafficking and degradation of mature bone morphogenetic protein-4.

http://www.wikidata.org/entity/Q37595180

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SIX2 and BMP4 mutations associate with anomalous kidney development The pro-form of BMP-2 interferes with BMP-2 signalling by competing with BMP-2 for IA receptor binding Bone Morphogenetic Protein 4 Signalling in Neural Stem and Progenitor Cells during Development and after Injury A Tale from TGF-β Superfamily for Thymus Ontogeny and Function Fine-tuned shuttles for bone morphogenetic proteins Targeting of bone morphogenetic protein growth factor complexes to fibrillin Individual carboxypeptidase D domains have both redundant and unique functions in Drosophila development and behavior.Analysis of Thisbe and Pyramus functional domains reveals evidence for cleavage of Drosophila FGFs Simultaneous rather than ordered cleavage of two sites within the BMP4 prodomain leads to loss of ligand in mice A translational block to HSPG synthesis permits BMP signaling in the early Drosophila embryo.Regulation of bone morphogenetic protein 9 (BMP9) by redox-dependent proteolysis.Identification of a pH sensor in the furin propeptide that regulates enzyme activation Sortilin associates with transforming growth factor-beta family proteins to enhance lysosome-mediated degradation.Crimpy inhibits the BMP homolog Gbb in motoneurons to enable proper growth control at the Drosophila neuromuscular junction Nodal·Gdf1 heterodimers with bound prodomains enable serum-independent nodal signaling and endoderm differentiation.Prodomain removal enables neto to stabilize glutamate receptors at the Drosophila neuromuscular junction The prodomain of BMP4 is necessary and sufficient to generate stable BMP4/7 heterodimers with enhanced bioactivity in vivo Loss of endothelial furin leads to cardiac malformation and early postnatal death.Mechanical Forces Reshape Differentiation Cues That Guide Cardiomyogenesis.A large bioactive BMP ligand with distinct signaling properties is produced by alternative proconvertase processing.Propeptides of eukaryotic proteases encode histidines to exploit organelle pH for regulation.A concentration-dependent endocytic trap and sink mechanism converts Bmper from an activator to an inhibitor of Bmp signaling.The Drosophila DPP signal is produced by cleavage of its proprotein at evolutionary diversified furin-recognition sites.Unveiling the bmp13 enigma: redundant morphogen or crucial regulator?Site-specific cleavage of BMP4 by furin, PC6, and PC7.Morphogen transport: theoretical and experimental controversies.The CDX2 transcription factor regulates furin expression during intestinal epithelial cell differentiation.Matters of context guide future research in TGFβ superfamily signaling.Agonists and Antagonists of TGF-β Family Ligands.The factor VII-activating protease (FSAP) enhances the activity of bone morphogenetic protein-2 (BMP-2).Expression of codon optimized human bone morphogenetic protein 4 in Pichia pastoris.MEPE activated by furin promotes pulpal cell adhesion.Parallel Activin and BMP signaling coordinates R7/R8 photoreceptor subtype pairing in the stochastic Drosophila retina.Different requirements for proteolytic processing of bone morphogenetic protein 5/6/7/8 ligands in Drosophila melanogaster Activin A binds to perlecan through its pro-region that has heparin/heparan sulfate binding activity.Regulation of Dpp activity by tissue-specific cleavage of an upstream site within the prodomain.The pro-peptide of proNGF: structure formation and intramolecular association with NGF.Transferrin receptor 2 and HFE regulate furin expression via mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/Erk) signaling. Implications for transferrin-dependent hepcidin regulation.Cathepsin H indirectly regulates morphogenetic protein-4 (BMP-4) in various human cell lines.Dynamics of BMP signaling and distribution during zebrafish dorsal-ventral patterning.

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Cleavages within the prodomain direct intracellular trafficking and degradation of mature bone morphogenetic protein-4.

http://www.wikidata.org/entity/Q37595180

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 08 September 2004

@en

vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Cleavages within the prodomain ...... bone morphogenetic protein-4.

@en

Cleavages within the prodomain ...... bone morphogenetic protein-4.

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type

label

Cleavages within the prodomain ...... bone morphogenetic protein-4.

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Cleavages within the prodomain ...... bone morphogenetic protein-4.

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prefLabel

Cleavages within the prodomain ...... bone morphogenetic protein-4.

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Cleavages within the prodomain ...... bone morphogenetic protein-4.

@nl

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MBC.E04-08-0673

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Molecular Biology of the Cell

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Cleavages within the prodomain ...... bone morphogenetic protein-4.

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Catherine Degnin

http://www.w3.org/2001/XMLSchema#string

François Jean

http://www.w3.org/2001/XMLSchema#string

Gary Thomas

http://www.w3.org/2001/XMLSchema#string

Jan L Christian

http://www.w3.org/2001/XMLSchema#string

P2860

Haploinsufficient Bmp4 ocular phenotypes include anterior segment dysgenesis with elevated intraocular pressure

Heterozygous mutations in the gene encoding noggin affect human joint morphogenesis

Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite

Bmp4 is required for the generation of primordial germ cells in the mouse embryo

Furin at the cutting edge: from protein traffic to embryogenesis and disease

The crystal structure of the proprotein processing proteinase furin explains its stringent specificity

Mechanisms of TGF-beta signaling from cell membrane to the nucleus

Precursor processing by kex2/furin proteases

Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton

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5012-5020

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scholarly article

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10.1091/MBC.E04-08-0673

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11

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15

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2004-09-08T00:00:00Z

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15356272

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