Role of the proximal enhancer of the major immediate-early promoter in human cytomegalovirus replication.
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Prolonged activation of NF-kappaB by human cytomegalovirus promotes efficient viral replication and late gene expressionThe human cytomegalovirus UL76 gene regulates the level of expression of the UL77 gene.Two Sp1/Sp3 binding sites in the major immediate-early proximal enhancer of human cytomegalovirus have a significant role in viral replication.Alternative splicing of the human cytomegalovirus major immediate-early genes affects infectious-virus replication and control of cellular cyclin-dependent kinase.Inhibition of cellular DNA synthesis by the human cytomegalovirus IE86 protein is necessary for efficient virus replication.High-efficiency promoter-dependent transduction by adeno-associated virus type 6 vectors in mouse lung.Mouse cytomegalovirus crosses the species barrier with help from a few human cytomegalovirus proteinsThe human cytomegalovirus gene products essential for late viral gene expression assemble into prereplication complexes before viral DNA replication.Human cytomegalovirus replication is strictly inhibited by siRNAs targeting UL54, UL97 or UL122/123 gene transcriptsThe late promoter of the human cytomegalovirus viral DNA polymerase processivity factor has an impact on delayed early and late viral gene products but not on viral DNA synthesisThe human cytomegalovirus virion possesses an activated casein kinase II that allows for the rapid phosphorylation of the inhibitor of NF-kappaB, IkappaBalpha.The autoregulatory and transactivating functions of the human cytomegalovirus IE86 protein use independent mechanisms for promoter binding.A cis element between the TATA Box and the transcription start site of the major immediate-early promoter of human cytomegalovirus determines efficiency of viral replication.Noncanonical TATA sequence in the UL44 late promoter of human cytomegalovirus is required for the accumulation of late viral transcripts.In vivo competence of murine cytomegalovirus under the control of the human cytomegalovirus major immediate-early enhancer in the establishment of latency and reactivation.Multiple Transcripts Encode Full-Length Human Cytomegalovirus IE1 and IE2 Proteins during Lytic Infection.The CREB site in the proximal enhancer is critical for cooperative interaction with the other transcription factor binding sites to enhance transcription of the major intermediate-early genes in human cytomegalovirus-infected cells.Epstein-Barr virus polymerase processivity factor enhances BALF2 promoter transcription as a coactivator for the BZLF1 immediate-early protein.Coordination of late gene transcription of human cytomegalovirus with viral DNA synthesis: recombinant viruses as potential therapeutic vaccine candidates.Regulation of the transcription and replication cycle of human cytomegalovirus is insensitive to genetic elimination of the cognate NF-kappaB binding sites in the enhancer.Insertion of myeloid-active elements into the human cytomegalovirus major immediate early promoter is not sufficient to drive its activation upon infection of undifferentiated myeloid cells.Human cytomegalovirus blocks tumor necrosis factor alpha- and interleukin-1beta-mediated NF-kappaB signaling.The human cytomegalovirus gene UL79 is required for the accumulation of late viral transcripts.The activator protein 1 binding motifs within the human cytomegalovirus major immediate-early enhancer are functionally redundant and act in a cooperative manner with the NF-{kappa}B sites during acute infectionEpstein-Barr virus deubiquitinase downregulates TRAF6-mediated NF-κB signaling during productive replication.Kaposi sarcoma-associated herpes virus (KSHV) G protein-coupled receptor (vGPCR) activates the ORF50 lytic switch promoter: a potential positive feedback loop for sustained ORF50 gene expressionActivation of the virus-induced IKK/NF-kappaB signalling axis is critical for the replication of human cytomegalovirus in quiescent cells.Analysis of human cytomegalovirus replication in primary cultured human corneal endothelial cells.Tetrameric ring formation of Epstein-Barr virus polymerase processivity factor is crucial for viral replication.Murine cytomegalovirus major immediate-early enhancer region operating as a genetic switch in bidirectional gene pair transcription.Human cytomegalovirus-encoded chemokine receptor homolog US28 stimulates the major immediate early gene promoter/enhancer via the induction of CREB.Using a Commonly Down-Regulated Cytomegalovirus (CMV) Promoter for High-Level Expression of Ectopic Gene in a Human B Lymphoma Cell Line.The 5' Untranslated Region of the Major Immediate Early mRNA is Necessary for Efficient Human Cytomegalovirus Replication.Visualization of Synchronous or Asynchronous Release of Single Synaptic Vesicle in Active-Zone-Like Membrane Formed on Neuroligin-Coated Glass Surface.
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Role of the proximal enhancer of the major immediate-early promoter in human cytomegalovirus replication.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on December 2004
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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Role of the proximal enhancer ...... n cytomegalovirus replication.
@en
Role of the proximal enhancer ...... n cytomegalovirus replication.
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Role of the proximal enhancer ...... n cytomegalovirus replication.
@en
Role of the proximal enhancer ...... n cytomegalovirus replication.
@nl
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Role of the proximal enhancer ...... n cytomegalovirus replication.
@en
Role of the proximal enhancer ...... n cytomegalovirus replication.
@nl
P2093
P2860
P1433
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Role of the proximal enhancer ...... n cytomegalovirus replication.
@en
P2093
Hiroki Isomura
Mark F Stinski
Tatsuya Tsurumi
P2860
P304
12788-12799
P356
10.1128/JVI.78.23.12788-12799.2004
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P577
2004-12-01T00:00:00Z