Analysing the role of endogenous matrix molecules in the development of osteoarthritis.
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Regulation of the innate immune response by fibronectin: synergism between the III-1 and EDA domainsAn intron polymorphism of the fibronectin gene is associated with end-stage knee osteoarthritis in a Han Chinese population: two independent case-control studies.Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis.What makes osteoarthritis painful? The evidence for local and central pain processing.Identification of a central role for complement in osteoarthritis.Joint pathology and platelet-rich plasma therapies.Regulation of MMP-3 expression and secretion by the chemokine eotaxin-1 in human chondrocytesGene-gene interactions between TGF-β/Smad3 signalling pathway polymorphisms affect susceptibility to knee osteoarthritis.Protein modification by deamidation indicates variations in joint extracellular matrix turnoverPro-inflammatory cytokines and structural biomarkers are effective to categorize osteoarthritis phenotype and progression in Standardbred racehorses over five years of racing career.Tenascin-C fragments are endogenous inducers of cartilage matrix degradation.Intra-articular injections for the treatment of osteoarthritis: focus on the clinical use of hyaluronic acid.Synovium and the innate inflammatory network in osteoarthritis progression.Aspartic acid racemization reveals a high turnover state in knee compared with hip osteoarthritic cartilage.Homeostatic mechanisms in articular cartilage and role of inflammation in osteoarthritis.Review: the role of microRNAs in osteoarthritis and chondrogenesis.Fibronectin in tissue regeneration: timely disassembly of the scaffold is necessary to complete the build.Integrin signaling in skeletal development and function.Current serological possibilities for the diagnosis of arthritis with special focus on proteins and proteoglycans from the extracellular matrix.TLR4 signalling in osteoarthritis--finding targets for candidate DMOADs.Cryptic activity within the Type III1 domain of fibronectin regulates tissue inflammation and angiogenesis.Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4.Reduction of friction by recombinant human proteoglycan 4 in IL-1α stimulated bovine cartilage explants.Microarray analysis of bone marrow lesions in osteoarthritis demonstrates upregulation of genes implicated in osteochondral turnover, neurogenesis and inflammation.Fibronectin III 13-14 domains induce joint damage via Toll-like receptor 4 activation and synergize with interleukin-1 and tumour necrosis factor.Mechanical impact induces cartilage degradation via mitogen activated protein kinases.Increasing UCP2 expression and decreasing NOX1/4 expression maintain chondrocyte phenotype by reducing reactive oxygen species productionAbsolute quantification of selected proteins in the human osteoarthritic secretome.The potential protective effects of calcitonin involved in coordinating chondrocyte response, extracellular matrix, and subchondral trabecular bone in experimental osteoarthritis.Author's reply to: Comment on: Fibronectin in tissue regeneration: timely disassembly of the scaffold is necessary to complete the build.Osteoarthritis and the Complement Cascade.Unconventional T-cell recognition of an arthritogenic epitope of proteoglycan aggrecan released from degrading cartilage.BAPX-1/NKX-3.2 acts as a chondrocyte hypertrophy molecular switch in osteoarthritis.Beta-arrestin 1 is involved in the catabolic response stimulated by hyaluronan degradation in mouse chondrocytes.Genetic abrogation of the fibronectin-α5β1 integrin interaction in articular cartilage aggravates osteoarthritis in mice.Changes in the integrins expression are related with the osteoarthritis severity in an experimental animal model in ratsExpression and regulation of toll-like receptors (TLRs) in human intervertebral disc cells
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P2860
Analysing the role of endogenous matrix molecules in the development of osteoarthritis.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on October 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Analysing the role of endogenous matrix molecules in the development of osteoarthritis.
@en
Analysing the role of endogenous matrix molecules in the development of osteoarthritis.
@nl
type
label
Analysing the role of endogenous matrix molecules in the development of osteoarthritis.
@en
Analysing the role of endogenous matrix molecules in the development of osteoarthritis.
@nl
prefLabel
Analysing the role of endogenous matrix molecules in the development of osteoarthritis.
@en
Analysing the role of endogenous matrix molecules in the development of osteoarthritis.
@nl
P2860
P1476
Analysing the role of endogenous matrix molecules in the development of osteoarthritis
@en
P2093
Nidhi Sofat
P2860
P304
P356
10.1111/J.1365-2613.2009.00676.X
P50
P577
2009-10-01T00:00:00Z