Function and regulation of the mitochondrial sirtuin isoform Sirt5 in Mammalia.
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Targeting mitochondrial reactive oxygen species as novel therapy for inflammatory diseases and cancersA Molecular Mechanism for Direct Sirtuin Activation by ResveratrolEx-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanismStructures of human sirtuin 3 complexes with ADP-ribose and with carba-NAD+ and SRT1720: binding details and inhibition mechanismChemical probing of the human sirtuin 5 active site reveals its substrate acyl specificity and peptide-based inhibitorsDifferential effects of binge methamphetamine injections on the mRNA expression of histone deacetylases (HDACs) in the rat striatumAn acetylome peptide microarray reveals specificities and deacetylation substrates for all human sirtuin isoforms.Role of the Substrate Specificity-Defining Residues of Human SIRT5 in Modulating the Structural Stability and Inhibitory Features of the Enzyme.Structure-based development of novel sirtuin inhibitors.Sirt5 deacylation activities show differential sensitivities to nicotinamide inhibition.Beyond histone and deacetylase: an overview of cytoplasmic histone deacetylases and their nonhistone substratesModulation of acetylation: creating a pro-survival and anti-inflammatory phenotype in lethal hemorrhagic and septic shock.Striatal molecular signature of subchronic subthalamic nucleus high frequency stimulation in parkinsonian rat.Using mitochondrial sirtuins as drug targets: disease implications and available compounds.Generation and Purification of Catalytically Active Recombinant Sirtuin5 (SIRT5) Protein.Sirtuins in glucose and lipid metabolism.Sirtuin activators and inhibitors.Sirtuins and cancer: new insights and cell signaling.New assays and approaches for discovery and design of Sirtuin modulators.Roles of sirtuins in the regulation of antioxidant defense and bioenergetic function of mitochondria under oxidative stress.The sirtuins: Markers of metabolic health.Nutritional biomarkers: Current view and future perspectives.Sirtuin 5: a review of structure, known inhibitors and clues for developing new inhibitors.Neuroprotective effects of nicotinamide N-methyltransferase and its metabolite 1-methylnicotinamide.Molecular architecture of the human protein deacetylase Sirt1 and its regulation by AROS and resveratrol.Structures, substrates, and regulators of Mammalian sirtuins - opportunities and challenges for drug development.Resveratrol stimulates cortisol biosynthesis by activating SIRT-dependent deacetylation of P450sccInterplay between Intravitreal RvD1 and Local Endogenous Sirtuin-1 in the Protection from Endotoxin-Induced Uveitis in Rats.Crystal structures of the mitochondrial deacylase Sirtuin 4 reveal isoform-specific acyl recognition and regulation features.Chemical Probing of the Human Sirtuin 5 Active Site Reveals Its Substrate Acyl Specificity and Peptide-Based InhibitorsMelatonin Mitigates Mitochondrial Meltdown: Interactions with SIRT3
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P2860
Function and regulation of the mitochondrial sirtuin isoform Sirt5 in Mammalia.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 18 September 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Function and regulation of the mitochondrial sirtuin isoform Sirt5 in Mammalia.
@en
Function and regulation of the mitochondrial sirtuin isoform Sirt5 in Mammalia.
@nl
type
label
Function and regulation of the mitochondrial sirtuin isoform Sirt5 in Mammalia.
@en
Function and regulation of the mitochondrial sirtuin isoform Sirt5 in Mammalia.
@nl
prefLabel
Function and regulation of the mitochondrial sirtuin isoform Sirt5 in Mammalia.
@en
Function and regulation of the mitochondrial sirtuin isoform Sirt5 in Mammalia.
@nl
P1476
Function and regulation of the mitochondrial sirtuin isoform Sirt5 in Mammalia.
@en
P2093
Clemens Steegborn
Melanie Gertz
P304
P356
10.1016/J.BBAPAP.2009.09.011
P407
P577
2009-09-18T00:00:00Z