Engineering the substrate specificity of glutathione reductase toward that of trypanothione reduction
about
The NADPH-dependent thioredoxin system constitutes a functional backup for cytosolic glutathione reductase in ArabidopsisX-ray structure of trypanothione reductase from Crithidia fasciculata at 2.4-A resolutionBinding to large enzyme pockets: small-molecule inhibitors of trypanothione reductaseRoles of the redox-active disulfide and histidine residues forming a catalytic dyad in reactions catalyzed by 2-ketopropyl coenzyme M oxidoreductase/carboxylase.Glutathionylspermidine metabolism in Escherichia coli.Cation-pi bonding and amino-aromatic interactions in the biomolecular recognition of substituted ammonium ligands.A model of redox kinetics implicates the thiol proteome in cellular hydrogen peroxide responsesStructure of glutathione reductase from Escherichia coli at 1.86 A resolution: comparison with the enzyme from human erythrocytes.Rationally designed selective inhibitors of trypanothione reductase. Phenothiazines and related tricyclics as lead structuresAltering kinetic mechanism and enzyme stability by mutagenesis of the dimer interface of glutathione reductase.Redesign of the substrate specificity of Escherichia coli aspartate aminotransferase to that of Escherichia coli tyrosine aminotransferase by homology modeling and site-directed mutagenesis.The crystal structure of trypanothione reductase from the human pathogen Trypanosoma cruzi at 2.3 A resolution.Cruzain inhibition by hydroxymethylnitrofurazone and nitrofurazone: investigation of a new target in Trypanosoma cruzi.Asymmetric synthesis of D-glyceric acid by an alditol oxidase and directed evolution for enhanced oxidative activity towards glycerol
P2860
Q24651469-608019C5-F29E-47C7-A01F-6C8EC2860154Q27653946-C6992BAF-80CA-4507-B971-0EDF509F9676Q27690137-85A77063-89B4-459E-967C-C0BAE64AE115Q35192384-CBF50A7C-2BE9-4A7F-8FBE-AA2C22C49DD0Q39472639-37D4CFA0-25C6-4594-B634-1394B5C47AF7Q41165869-4285B838-2BE2-446C-B430-5C3E71CEE552Q41863869-CED0D84B-BF20-4E37-856F-F4D1587A06E3Q41966807-A981AD22-B0F4-430C-B659-4F4E9C6737C8Q42152987-FFBC18E1-3267-4858-A6FA-8129184CD465Q42183689-C605BA07-22DC-4BB7-BBFE-39834765B79CQ42844930-4228451F-BF2D-47CC-9AEC-740C8F0D25CFQ42844963-439F6685-D6F4-4C97-BF0A-1549BDE9CA32Q43210251-B54CD40E-B174-424B-A667-39377B244831Q56894908-0CB5F57A-C2F7-4A01-A853-9C62D0553518
P2860
Engineering the substrate specificity of glutathione reductase toward that of trypanothione reduction
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on October 1991
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Engineering the substrate spec ...... hat of trypanothione reduction
@en
Engineering the substrate spec ...... at of trypanothione reduction.
@nl
type
label
Engineering the substrate spec ...... hat of trypanothione reduction
@en
Engineering the substrate spec ...... at of trypanothione reduction.
@nl
prefLabel
Engineering the substrate spec ...... hat of trypanothione reduction
@en
Engineering the substrate spec ...... at of trypanothione reduction.
@nl
P2093
P2860
P356
P1476
Engineering the substrate spec ...... hat of trypanothione reduction
@en
P2093
G B Henderson
N J Murgolo
N S Scrutton
N W Hinchliffe
R N Perham
P2860
P304
P356
10.1073/PNAS.88.19.8769
P407
P577
1991-10-01T00:00:00Z