Identification of the Fc gamma receptor class I binding site in human IgG through the use of recombinant IgG1/IgG2 hybrid and point-mutated antibodies.
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Localization of the binding site for the monocyte immunoglobulin (Ig) A-Fc receptor (CD89) to the domain boundary between Calpha2 and Calpha3 in human IgA1Structure of the Fc fragment of human IgE bound to its high-affinity receptor Fc epsilonRI alphaThe 3.2-A crystal structure of the human IgG1 Fc fragment-Fc gammaRIII complexThe structure of a human type III Fcgamma receptor in complex with FcStructural characterization of a human Fc fragment engineered for lack of effector functionsCrystal Structure of Fc Receptor I and Its Implication in High Affinity -Immunoglobulin BindingHuman IgG is produced in a pro-form that requires clipping of C-terminal lysines for maximal complement activationSolid-phase synthesis and cyclization of a large branched peptide from IgG Fc with affinity for Fc gammaRI.Identification of chimpanzee Fab fragments by repertoire cloning and production of a full-length humanized immunoglobulin G1 antibody that is highly efficient for neutralization of dengue type 4 virus.Chimpanzee Fab fragments and a derived humanized immunoglobulin G1 antibody that efficiently cross-neutralize dengue type 1 and type 2 viruses.Identification of cyclic peptides able to mimic the functional epitope of IgG1-Fc for human Fc gammaRI.Natural form of noncytolytic flexible human Fc as a long-acting carrier of agonistic ligand, erythropoietin.Construction of a stability landscape of the CH3 domain of human IgG1 by combining directed evolution with high throughput sequencing.IgG subclasses and allotypes: from structure to effector functions.Transferrin-antibody fusion proteins are effective in brain targetingSoluble PD-1 rescues the proliferative response of simian immunodeficiency virus-specific CD4 and CD8 T cells during chronic infection.Hydrodynamic delivery of plasmid DNA encoding human FcγR-Ig dimers blocks immune-complex mediated inflammation in miceStructural insights into the interaction of human IgG1 with FcγRI: no direct role of glycans in binding.Extravasations and emigration of neutrophils to the inflammatory site depend on the interaction of immune-complex with Fcgamma receptors and can be effectively blocked by decoy Fcgamma receptors.Homogeneous immunoconjugates for boron neutron-capture therapy: design, synthesis, and preliminary characterization.The high-affinity receptor for IgG, FcγRI, of humans and non-human primates.Regulation of antibody effector functions through IgG Fc N-glycosylation.Dynamics of the interaction of human IgG subtype immune complexes with cells expressing R and H allelic forms of a low-affinity Fc gamma receptor CD32A.Hybrid antibodies.IgG binding sites on human Fc gamma receptors.Recombinant human IgG molecules lacking Fcgamma receptor I binding and monocyte triggering activities.Optimization of experimental conditions for functional in vitro characterization of humanized antibodies specific for staphylococcal enterotoxin B.In vitro assessment of the effects of vedolizumab binding on peripheral blood lymphocytesCynomolgus and pigtail macaque IgG subclasses: characterization of IGHG genes and computational analysis of IgG/Fc receptor binding affinity.IgG2m4, an engineered antibody isotype with reduced Fc function.Recognition of IgG by Fcgamma receptor. The role of Fc glycosylation and the binding of peptide inhibitors.High resolution mapping of the binding site on human IgG1 for Fc gamma RI, Fc gamma RII, Fc gamma RIII, and FcRn and design of IgG1 variants with improved binding to the Fc gamma R.The antibody loci of the domestic goat (Capra hircus).Effector-attenuating Substitutions That Maintain Antibody Stability and Reduce Toxicity in Mice.IgG Fc engineering to modulate antibody effector functions.Engineering therapeutic monoclonal antibodies.Affinity and kinetic analysis of Fcgamma receptor IIIa (CD16a) binding to IgG ligands.Therapeutic Administration of Broadly Neutralizing FI6 Antibody Reveals Lack of Interaction Between Human IgG1 and Pig Fc Receptors.Fc engineering of anti-Nectin-2 antibody improved thrombocytopenic adverse event in monkey.
P2860
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P2860
Identification of the Fc gamma receptor class I binding site in human IgG through the use of recombinant IgG1/IgG2 hybrid and point-mutated antibodies.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on October 1991
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Identification of the Fc gamma ...... and point-mutated antibodies.
@en
Identification of the Fc gamma ...... and point-mutated antibodies.
@nl
type
label
Identification of the Fc gamma ...... and point-mutated antibodies.
@en
Identification of the Fc gamma ...... and point-mutated antibodies.
@nl
prefLabel
Identification of the Fc gamma ...... and point-mutated antibodies.
@en
Identification of the Fc gamma ...... and point-mutated antibodies.
@nl
P2093
P2860
P356
P1476
Identification of the Fc gamma ...... and point-mutated antibodies.
@en
P2093
P2860
P304
P356
10.1073/PNAS.88.20.9036
P407
P577
1991-10-01T00:00:00Z