Yeast cells expressing the human mitochondrial DNA polymerase reveal correlations between polymerase fidelity and human disease progression
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DNA polymerase γ and disease: what we have learned from yeastEfforts to make and apply humanized yeastPolymorphisms in DNA polymerase γ affect the mtDNA stability and the NRTI-induced mitochondrial toxicity in Saccharomyces cerevisiae.Alpers disease mutations in human DNA polymerase gamma cause catalytic defects in mitochondrial DNA replication by distinct mechanismsScope and limitations of yeast as a model organism for studying human tissue-specific pathways.Yeast model analysis of novel polymerase gamma variants found in patients with autosomal recessive mitochondrial disease.DNA polymerase beta participates in mitochondrial DNA repair.A multi-systemic mitochondrial disorder due to a dominant p.Y955H disease variant in DNA polymerase gamma.Combined use of Saccharomyces cerevisiae, Caenorhabditis elegans and patient fibroblasts leads to the identification of clofilium tosylate as a potential therapeutic chemical against POLG-related diseases.RNA Aptamers Rescue Mitochondrial Dysfunction in a Yeast Model of Huntington’s Disease.
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Yeast cells expressing the human mitochondrial DNA polymerase reveal correlations between polymerase fidelity and human disease progression
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 07 January 2014
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Yeast cells expressing the hum ...... and human disease progression
@en
Yeast cells expressing the hum ...... and human disease progression.
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type
label
Yeast cells expressing the hum ...... and human disease progression
@en
Yeast cells expressing the hum ...... and human disease progression.
@nl
prefLabel
Yeast cells expressing the hum ...... and human disease progression
@en
Yeast cells expressing the hum ...... and human disease progression.
@nl
P2093
P2860
P356
P1476
Yeast cells expressing the hum ...... and human disease progression
@en
P2093
Christopher M Yellman
Kenneth A Johnson
Yufeng Qian
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P304
P356
10.1074/JBC.M113.526418
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P577
2014-01-07T00:00:00Z