Prothrombinase complex assembly on the platelet surface is mediated through the 74,000-dalton component of factor Va.
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Human platelets contain and secrete osteonectin, a major protein of mineralized boneCloning of a cDNA coding for human factor V, a blood coagulation factor homologous to factor VIII and ceruloplasminRoles of factor Va heavy and light chains in protein and lipid rearrangements associated with the formation of a bovine factor Va-membrane complex.In vivo relevance for platelet glycoprotein Ibalpha residue Tyr276 in thrombus formation.Flow cytometric measurement of platelet function and reticulated platelets.C-terminal residues 621-635 of protein S are essential for binding to factor Va.Binding sites for blood coagulation factor Xa and protein S involving residues 493-506 in factor Va.Prothrombin activation by platelet-associated prothrombinase proceeds through the prethrombin-2 pathway via a concerted mechanism.Proteolysis of plasma-derived factor V following its endocytosis by megakaryocytes forms the platelet-derived factor V/Va pool.Binding of bovine factor Va to phosphatidylcholine membranes.Dynamics of Thrombin Generation and Flux from Clots during Whole Human Blood Flow over Collagen/Tissue Factor Surfaces.Mechanism of factor Va inactivation by plasmin. Loss of A2 and A3 domains from a Ca2+-dependent complex of fragments bound to phospholipid.Binding site for blood coagulation factor Xa involving residues 311-325 in factor Va.Factor V is complexed with multimerin in resting platelet lysates and colocalizes with multimerin in platelet alpha-granulesDifferences in prethrombin-1 activation with human or bovine factor Va can be attributed to the heavy chain.Importance of individual activated protein C cleavage site regions in coagulation factor V for factor Va inactivation and for factor Xa activation.
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P2860
Prothrombinase complex assembly on the platelet surface is mediated through the 74,000-dalton component of factor Va.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on April 1983
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Prothrombinase complex assembl ...... dalton component of factor Va.
@en
Prothrombinase complex assembl ...... dalton component of factor Va.
@nl
type
label
Prothrombinase complex assembl ...... dalton component of factor Va.
@en
Prothrombinase complex assembl ...... dalton component of factor Va.
@nl
prefLabel
Prothrombinase complex assembl ...... dalton component of factor Va.
@en
Prothrombinase complex assembl ...... dalton component of factor Va.
@nl
P2860
P356
P1476
Prothrombinase complex assembl ...... dalton component of factor Va.
@en
P2093
P2860
P304
P356
10.1073/PNAS.80.8.2380
P407
P577
1983-04-01T00:00:00Z