Kinetics of insulin aggregation in aqueous solutions upon agitation in the presence of hydrophobic surfaces.
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The 8 and 5 kDa fragments of plasma gelsolin form amyloid fibrils by a nucleated polymerization mechanism, while the 68 kDa fragment is not amyloidogenicFibrillogenic propensity of the GroEL apical domain: a Janus-faced minichaperonePeptides that form β-sheets on hydrophobic surfaces accelerate surface-induced insulin amyloidal aggregationMicro-flow imaging: flow microscopy applied to sub-visible particulate analysis in protein formulationsNanoparticle based insulin delivery system: the next generation efficient therapy for Type 1 diabetesUV-light exposed prion protein fails to form amyloid fibrilsShaking alone induces de novo conversion of recombinant prion proteins to β-sheet rich oligomers and fibrilsStorage stability of keratinocyte growth factor-2 in lyophilized formulations: effects of formulation physical properties and protein fraction at the solid-air interface.Intrinsic fibrillation of fast-acting insulin analogs.Materials for diabetes therapeutics.Distinguishing crystal-like amyloid fibrils and glass-like amorphous aggregates from their kinetics of formation.Optical microscopy of growing insulin amyloid spherulites on surfaces in vitro.Role of a novel excipient poly(ethylene glycol)-b-poly(L-histidine) in retention of physical stability of insulin at aqueous/organic interface.Role of small oligomers on the amyloidogenic aggregation free-energy landscapeDynamics of protofibril elongation and association involved in Aβ42 peptide aggregation in Alzheimer's disease.pH-dependent self-association of zinc-free insulin characterized by concentration-gradient static light scattering.Sulfate anion delays the self-assembly of human insulin by modifying the aggregation pathway.Monitoring insulin aggregation via capillary electrophoresisCharacterization of the oligomeric states of insulin in self-assembly and amyloid fibril formation by mass spectrometryEarly events in insulin fibrillization studied by time-lapse atomic force microscopy.Inhibition study on insulin fibrillation and cytotoxicity by paclitaxel.Unlocking Chain Exchange in Highly Amphiphilic Block Polymer Micellar Systems: Influence of Agitation.Comparative pharmacodynamic and pharmacokinetic characteristics of subcutaneous insulin glulisine and insulin aspart prior to a standard meal in obese subjects with type 2 diabetes.Modeling of chemical inhibition from amyloid protein aggregation kinetics.A three-stage kinetic model of amyloid fibrillation.Controlling amyloid fibril formation by partial stirring.Nucleation and growth of insulin fibrils in bulk solution and at hydrophobic polystyrene surfaces.Effects of shear flow on phase nucleation and crystallization.High-Throughput Screening Methodology to Identify Alpha-Synuclein Aggregation Inhibitors.Low within- and between-day variability in exposure to new insulin glargine 300 U/ml.Inhibition of amyloid peptide fibrillation by inorganic nanoparticles: functional similarities with proteinsComputational modeling of the relationship between amyloid and disease.On-surface aggregation of α-synuclein at nanomolar concentrations results in two distinct growth mechanismsSurfactant Effects on Particle Generation in Antibody Formulations in Pre-filled SyringesKinetics of Protein Complex Dissociation Studied by Hydrogen/Deuterium Exchange and Mass Spectrometry.Biodegradable polymers for microencapsulation of drugs.Chemical and biophysical insights into the propagation of prion strains.Effects of glycosylation on the stability of protein pharmaceuticals.Interaction of IAPP and insulin with model interfaces studied using neutron reflectometry.Branching in amyloid fibril growth.
P2860
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P2860
Kinetics of insulin aggregation in aqueous solutions upon agitation in the presence of hydrophobic surfaces.
description
1991 nî lūn-bûn
@nan
1991年の論文
@ja
1991年学术文章
@wuu
1991年学术文章
@zh-cn
1991年学术文章
@zh-hans
1991年学术文章
@zh-my
1991年学术文章
@zh-sg
1991年學術文章
@yue
1991年學術文章
@zh
1991年學術文章
@zh-hant
name
Kinetics of insulin aggregatio ...... sence of hydrophobic surfaces.
@en
Kinetics of insulin aggregatio ...... sence of hydrophobic surfaces.
@nl
type
label
Kinetics of insulin aggregatio ...... sence of hydrophobic surfaces.
@en
Kinetics of insulin aggregatio ...... sence of hydrophobic surfaces.
@nl
prefLabel
Kinetics of insulin aggregatio ...... sence of hydrophobic surfaces.
@en
Kinetics of insulin aggregatio ...... sence of hydrophobic surfaces.
@nl
P2093
P2860
P356
P1476
Kinetics of insulin aggregatio ...... sence of hydrophobic surfaces.
@en
P2093
P2860
P304
P356
10.1073/PNAS.88.21.9377
P407
P577
1991-11-01T00:00:00Z