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Raf kinase inhibitor RKIP inhibits MDA-9/syntenin-mediated metastasis in melanoma

Raf kinase inhibitor RKIP inhibits MDA-9/syntenin-mediated metastasis in melanoma

http://www.wikidata.org/entity/Q37611006

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The biological complexity of RKIP signaling in human cancers Proteomic peptide phage display uncovers novel interactions of the PDZ1-2 supramodule of syntenin miR-27a regulates cisplatin resistance and metastasis by targeting RKIP in human lung adenocarcinoma cells Microenvironmental Influences on Metastasis Suppressor Expression and Function during a Metastatic Cell's Journey.Targeting tumor invasion: the roles of MDA-9/Syntenin.Syntenin is expressed in human gliomas and may correlate with tumor migration.Novel role of MDA-9/syntenin in regulating urothelial cell proliferation by modulating EGFR signaling.Metastasis suppressors in breast cancers: mechanistic insights and clinical potential Novel function of MDA-9/Syntenin (SDCBP) as a regulator of survival and stemness in glioma stem cells.RKIP: much more than Raf kinase inhibitory protein.MDA-9/Syntenin Control.Crosstalks between Raf-kinase inhibitor protein and cancer stem cell transcription factors (Oct4, KLF4, Sox2, Nanog).Knockout of MDA-9/Syntenin (SDCBP) expression in the microenvironment dampens tumor-supporting inflammation and inhibits melanoma metastasis.Down-regulated miR-23a Contributes to the Metastasis of Cutaneous Melanoma by Promoting Autophagy.Survival of metastatic melanoma patients after dendritic cell vaccination correlates with expression of leukocyte phosphatidylethanolamine-binding protein 1/Raf kinase inhibitory protein.Promoter methylation of Raf kinase inhibitory protein: A significant prognostic indicator for patients with gastric adenocarcinoma.IL-6 increases SDCBP expression, cell proliferation, and cell invasion by activating JAK2/STAT3 in human glioma cells.Metastasis suppressors: functional pathways.Raf Kinase Inhibitor Protein Preferentially Promotes TLR3-Triggered Signaling and Inflammation.RKIP mediates autoimmune inflammation by positively regulating IL-17R signaling.The MDA-9/Syntenin/IGF-1R/STAT3 axis directs prostate cancer invasion.MDA-9/Syntenin regulates protective autophagy in anoikis-resistant glioma stem cells.RKIP: A Key Regulator in Tumor Metastasis Initiation and Resistance to Apoptosis: Therapeutic Targeting and Impact Targeting Raf Kinase Inhibitory Protein Regulation and Function

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Raf kinase inhibitor RKIP inhibits MDA-9/syntenin-mediated metastasis in melanoma

http://www.wikidata.org/entity/Q37611006

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on 11 October 2012

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Raf kinase inhibitor RKIP inhibits MDA-9/syntenin-mediated metastasis in melanoma

@en

Raf kinase inhibitor RKIP inhibits MDA-9/syntenin-mediated metastasis in melanoma.

@nl

type

label

Raf kinase inhibitor RKIP inhibits MDA-9/syntenin-mediated metastasis in melanoma

@en

Raf kinase inhibitor RKIP inhibits MDA-9/syntenin-mediated metastasis in melanoma.

@nl

prefLabel

Raf kinase inhibitor RKIP inhibits MDA-9/syntenin-mediated metastasis in melanoma

@en

Raf kinase inhibitor RKIP inhibits MDA-9/syntenin-mediated metastasis in melanoma.

@nl

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0008-5472.CAN-12-0402

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Cancer Research

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Raf kinase inhibitor RKIP inhibits MDA-9/syntenin-mediated metastasis in melanoma

@en

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Belal Azab

http://www.w3.org/2001/XMLSchema#string

Devanand Sarkar

http://www.w3.org/2001/XMLSchema#string

Devasis Chatterjee

http://www.w3.org/2001/XMLSchema#string

Erika L Moen

http://www.w3.org/2001/XMLSchema#string

Habib Boukerche

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Maurizio Pellecchia

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Paul B Fisher

http://www.w3.org/2001/XMLSchema#string

Sujit K Bhutia

http://www.w3.org/2001/XMLSchema#string

Swadesh K Das

http://www.w3.org/2001/XMLSchema#string

Talha Anwar

http://www.w3.org/2001/XMLSchema#string

P2860

c-Src is a PDZ interaction partner and substrate of the E3 ubiquitin ligase Ligand-of-Numb protein X1

Syntenin is overexpressed and promotes cell migration in metastatic human breast and gastric cancer cell lines

Regulation of c-Src by binding to the PDZ domain of AF-6

KAI1, a metastasis suppressor gene for prostate cancer on human chromosome 11p11.2

Raf kinase inhibitor protein interacts with NF-kappaB-inducing kinase and TAK1 and inhibits NF-kappaB activation

Mechanism of suppression of the Raf/MEK/extracellular signal-regulated kinase pathway by the raf kinase inhibitor protein

Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP

PDZ domains: structural modules for protein complex assembly

RKIP downregulates B-Raf kinase activity in melanoma cancer cells

The PDZ protein MPP2 interacts with c-Src in epithelial cells

P304

6217-6226

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scholarly article

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10.1158/0008-5472.CAN-12-0402

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23

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72

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2012-10-11T00:00:00Z

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23066033

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3939082

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