Trans-presentation: a novel mechanism regulating IL-15 delivery and responses.
about
Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15The role of interleukin-15 in inflammation and immune responses to infection: implications for its therapeutic useOverlapping, additive and counterregulatory effects of type II and I interferons on myeloid dendritic cell functionsMAIT cells are activated during human viral infectionsSex bias in experimental immune-mediated, drug-induced liver injury in BALB/c mice: suggested roles for Tregs, estrogen, and IL-6HemaMax™, a recombinant human interleukin-12, is a potent mitigator of acute radiation injury in mice and non-human primatesHuman natural killer cell development in secondary lymphoid tissuesIL-15 trans-presentation regulates homeostasis of CD4(+) T lymphocytes.Role of NK cells in host defense against pulmonary type A Francisella tularensis infectionSimultaneous blockade of multiple immune system inhibitory checkpoints enhances antitumor activity mediated by interleukin-15 in a murine metastatic colon carcinoma modelNatural killer cells from children with type 1 diabetes have defects in NKG2D-dependent function and signalingIL-15 complexes induce NK- and T-cell responses independent of type I IFN signaling during rhinovirus infectionResident-Memory CD8 T Cells and mTOR: Generation, Protection, and Clinical Importance.Role of common-gamma chain cytokines in NK cell development and function: perspectives for immunotherapy.IL-15 administered by continuous infusion to rhesus macaques induces massive expansion of CD8+ T effector memory population in peripheral bloodSleeping Beauty Transposition of Chimeric Antigen Receptors Targeting Receptor Tyrosine Kinase-Like Orphan Receptor-1 (ROR1) into Diverse Memory T-Cell Populations.Interleukin-15 is required for immunosurveillance and immunoprevention of HER2/neu-driven mammary carcinogenesis.Cytomegalovirus reactivation after allogeneic transplantation promotes a lasting increase in educated NKG2C+ natural killer cells with potent function.Kruppel-like factor 4 (KLF4) promotes the survival of natural killer cells and maintains the number of conventional dendritic cells in the spleenDelivery of interleukin-15 to B16 melanoma by electroporation leads to tumor regression and long-term survivalIL-15, in synergy with RAE-1ɛ, stimulates TCR-independent proliferation and activation of CD8(+) T cells.A Mouse Model of Latent Tuberculosis Infection to Study Intervention Strategies to Prevent ReactivationSkeletal muscle interleukin 15 promotes CD8(+) T-cell function and autoimmune myositis.Deficiency of Interleukin-15 Confers Resistance to Obesity by Diminishing Inflammation and Enhancing the Thermogenic Function of Adipose Tissues.Sarcopenia, obesity, and natural killer cell immune senescence in aging: altered cytokine levels as a common mechanismTargeted cancer immunotherapy: Mimicking physiological trans-presentation of IL-15Design and characterization of a protein superagonist of IL-15 fused with IL-15Rα and a high-affinity T cell receptorIL-15-dependent balance between Foxp3 and RORγt expression impacts inflammatory bowel disease.Configuration-dependent Presentation of Multivalent IL-15:IL-15Rα Enhances the Antigen-specific T Cell Response and Anti-tumor ImmunityAnti-ovarian tumor response of donor peripheral blood mononuclear cells is due to infiltrating cytotoxic NK cellsSubstantial increase in the frequency of circulating CD4+NKG2D+ T cells in patients with cervical intraepithelial neoplasia grade 1.CCR7 expression alters memory CD8 T-cell homeostasis by regulating occupancy in IL-7- and IL-15-dependent niches.Chemotherapy and immunotherapy: A close interplay to fight cancer?NK cells activated by Interleukin-4 in cooperation with Interleukin-15 exhibit distinctive characteristics.Design and development of therapies using chimeric antigen receptor-expressing T cellsMulti-cellular natural killer (NK) cell clusters enhance NK cell activation through localizing IL-2 within the cluster.Identification of IFN-γ-producing T cells as the main mediators of the side effects associated to mouse interleukin-15 sustained exposureAstrocyte-derived interleukin-15 exacerbates ischemic brain injury via propagation of cellular immunityHomeostasis of IL-15 dependent lymphocyte subsets in the liver.Vaccination with tumor cells expressing IL-15 and IL-15Rα inhibits murine breast and prostate cancer.
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Trans-presentation: a novel mechanism regulating IL-15 delivery and responses.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 07 October 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Trans-presentation: a novel mechanism regulating IL-15 delivery and responses.
@en
Trans-presentation: a novel mechanism regulating IL-15 delivery and responses.
@nl
type
label
Trans-presentation: a novel mechanism regulating IL-15 delivery and responses.
@en
Trans-presentation: a novel mechanism regulating IL-15 delivery and responses.
@nl
prefLabel
Trans-presentation: a novel mechanism regulating IL-15 delivery and responses.
@en
Trans-presentation: a novel mechanism regulating IL-15 delivery and responses.
@nl
P2860
P1433
P1476
Trans-presentation: a novel mechanism regulating IL-15 delivery and responses.
@en
P2093
Kimberly S Schluns
Spencer W Stonier
P2860
P356
10.1016/J.IMLET.2009.09.009
P577
2009-10-07T00:00:00Z