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Development of monoclonal antibodies against human CYP11B1 and CYP11B2.

Development of monoclonal antibodies against human CYP11B1 and CYP11B2.

http://www.wikidata.org/entity/Q37612477

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Primary Aldosteronism: Changing Definitions and New Concepts of Physiology and Pathophysiology Both Inside and Outside the Kidney.Steroid metabolome analysis reveals prevalent glucocorticoid excess in primary aldosteronism Physiological and Pathological Roles in Human Adrenal of the Glomeruli-Defining Matrix Protein NPNT (Nephronectin).Arterial stiffness and blood pressure improvement in aldosterone-producing adenoma harboring KCNJ5 mutations after adrenalectomy.Association of CYP17A1 Genetic Polymorphisms and Susceptibility to Essential Hypertension in the Southwest Han Chinese Population.Normoaldosteronemic aldosterone-producing adenoma: immunochemical characterization and diagnostic implications Adrenal CYP11B1/2 expression in primary aldosteronism: immunohistochemical analysis using novel monoclonal antibodies.Different expression of 11β-hydroxylase and aldosterone synthase between aldosterone-producing microadenomas and macroadenomas.A novel KCNJ5-insT149 somatic mutation close to, but outside, the selectivity filter causes resistant hypertension by loss of selectivity for potassium Approach to the surgical management of primary aldosteronism.DACH1, a zona glomerulosa selective gene in the human adrenal, activates transforming growth factor-β signaling and suppresses aldosterone secretion Role of Ca(2+)/calmodulin-dependent protein kinase kinase in adrenal aldosterone production.LGR5 Activates Noncanonical Wnt Signaling and Inhibits Aldosterone Production in the Human Adrenal Immunohistochemical, genetic and clinical characterization of sporadic aldosterone-producing adenomas.Potassium channels related to primary aldosteronism: Expression similarities and differences between human and rat adrenals.Development of adrenal cortex zonation.Aldosterone-stimulating somatic gene mutations are common in normal adrenal glands Adrenal histopathology in primary aldosteronism: is it time for a change?Measurement of peripheral plasma 18-oxocortisol can discriminate unilateral adenoma from bilateral diseases in patients with primary aldosteronism.Activating mutations in CTNNB1 in aldosterone producing adenomas.Inhibition of the Tcf/beta-catenin complex increases apoptosis and impairs adrenocortical tumor cell proliferation and adrenal steroidogenesis.Molecular Heterogeneity in Aldosterone-Producing Adenomas 3β-Hydroxysteroid dehydrogenase isoforms in human aldosterone-producing adenoma.Regulation of aldosterone secretion by Cav1.3.Antiaging Gene Klotho Regulates Adrenal CYP11B2 Expression and Aldosterone Synthesis Gonadotropin-Releasing Hormone Stimulate Aldosterone Production in a Subset of Aldosterone-Producing Adenoma.Immunohistochemistry of the adrenal in primary aldosteronism Transcriptome Pathway Analysis of Pathological and Physiological Aldosterone-Producing Human Tissues.The prevalence of CTNNB1 mutations in primary aldosteronism and consequences for clinical outcomes.Regulation of aldosterone synthesis and secretion.Dissecting the molecular pathways of primary aldosteronism.Histopathological and genetic characterization of aldosterone-producing adenomas with concurrent subclinical cortisol hypersecretion: a case series.Discordance between Imaging and Immunohistochemistry in Unilateral Primary Aldosteronism.Hypomethylation of CYP11B2 in Aldosterone-Producing Adenoma.YPEL4 modulates HAC15 adrenal cell proliferation and is associated with tumor diameter Regulation of zonation and homeostasis in the adrenal cortex.Immunohistochemistry of aldosterone synthase leads the way to the pathogenesis of primary aldosteronism.Role of cAMP/PKA pathway and T-type calcium channels in the mechanism of action of serotonin in human adrenocortical cells.Intratumoral heterogeneity of steroidogenesis in aldosterone-producing adenoma revealed by intensive double- and triple-immunostaining for CYP11B2/B1 and CYP17.Double adrenocortical adenomas harboring independent KCNJ5 and PRKACA somatic mutations.

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Development of monoclonal antibodies against human CYP11B1 and CYP11B2.

http://www.wikidata.org/entity/Q37612477

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article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 08 December 2013

@en

vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Development of monoclonal antibodies against human CYP11B1 and CYP11B2.

@en

Development of monoclonal antibodies against human CYP11B1 and CYP11B2.

@nl

type

label

Development of monoclonal antibodies against human CYP11B1 and CYP11B2.

@en

Development of monoclonal antibodies against human CYP11B1 and CYP11B2.

@nl

prefLabel

Development of monoclonal antibodies against human CYP11B1 and CYP11B2.

@en

Development of monoclonal antibodies against human CYP11B1 and CYP11B2.

@nl

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J.MCE.2013.11.022

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Molecular and Cellular Endocrinology

P1476

Development of monoclonal antibodies against human CYP11B1 and CYP11B2.

@en

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C Richard Parker

http://www.w3.org/2001/XMLSchema#string

Carolina Velarde-Miranda

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Celso E Gomez-Sanchez

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Elise P Gomez-Sanchez

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Fumitoshi Satoh

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Hironobu Sasano

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Maria W Plonczynski

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Takashi Maekawa

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William Rainey

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Xin Qi

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P2860

Role of steroid 11 beta-hydroxylase and steroid 18-hydroxylase in the biosynthesis of glucocorticoids and mineralocorticoids in humans

The molecular biology, biochemistry, and physiology of human steroidogenesis and its disorders

The product of the CYP11B2 gene is required for aldosterone biosynthesis in the human adrenal cortex

Disabled-2 is expressed in adrenal zona glomerulosa and is involved in aldosterone secretion

Full deacylation of polyethylenimine dramatically boosts its gene delivery efficiency and specificity to mouse lung.

Physiological partial aldosterone resistance in human newborns.

Human adrenocortical carcinoma cell lines.

Effect on aging on plasma renin and aldosterone in normal man.

Comparison of aldosterone production among human adrenocortical cell lines.

Alteration of subcapsular adrenocortical zonation in humans with aging: the progenitor zone predominates over the previously well-developed zona glomerulosa after 40 years of age.

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111-117

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scholarly article

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10.1016/J.MCE.2013.11.022

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1-2

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2013-12-08T00:00:00Z

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259270029

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24325867

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