A monoclonal antibody interferes with TIMP-2 binding and incapacitates the MMP-2-activating function of multifunctional, pro-tumorigenic MMP-14/MT1-MMP.
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Regulatory mechanisms of anthrax toxin receptor 1-dependent vascular and connective tissue homeostasisDevelopment of a 'mouse and human cross-reactive' affinity-matured exosite inhibitory human antibody specific to TACE (ADAM17) for cancer immunotherapy.New strategies for targeting matrix metalloproteinasesMatrix metalloproteinases as breast cancer drivers and therapeutic targets.Selective function-blocking monoclonal human antibody highlights the important role of membrane type-1 matrix metalloproteinase (MT1-MMP) in metastasis.Active-site MMP-selective antibody inhibitors discovered from convex paratope synthetic libraries.An engineered TIMP2-based and enediyne-integrated fusion protein for targeting MMP-14 shows potent antitumor efficacy.Limited independent prognostic value of MMP-14 and MMP-2 expression in ovarian cancer.Development of a specific affinity-matured exosite inhibitor to MT1-MMP that efficiently inhibits tumor cell invasion in vitro and metastasis in vivoNovel Role for Matrix Metalloproteinase 9 in Modulation of Cholesterol Metabolism.Monitoring and Inhibiting MT1-MMP during Cancer Initiation and Progression.New approaches to selectively target cancer-associated matrix metalloproteinase activity.Modulation of Systemic Metabolism by MMP-2: From MMP-2 Deficiency in Mice to MMP-2 Deficiency in Patients.Reciprocal relationship between membrane type 1 matrix metalloproteinase and the algesic peptides of myelin basic protein contributes to chronic neuropathic pain.Therapeutic Potential of Matrix Metalloproteinase Inhibition in Breast Cancer.
P2860
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P2860
A monoclonal antibody interferes with TIMP-2 binding and incapacitates the MMP-2-activating function of multifunctional, pro-tumorigenic MMP-14/MT1-MMP.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 02 December 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
A monoclonal antibody interfer ...... ro-tumorigenic MMP-14/MT1-MMP.
@en
A monoclonal antibody interfer ...... ro-tumorigenic MMP-14/MT1-MMP.
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type
label
A monoclonal antibody interfer ...... ro-tumorigenic MMP-14/MT1-MMP.
@en
A monoclonal antibody interfer ...... ro-tumorigenic MMP-14/MT1-MMP.
@nl
prefLabel
A monoclonal antibody interfer ...... ro-tumorigenic MMP-14/MT1-MMP.
@en
A monoclonal antibody interfer ...... ro-tumorigenic MMP-14/MT1-MMP.
@nl
P2093
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A monoclonal antibody interfer ...... pro-tumorigenic MMP-14/MT1-MMP
@en
P2093
A G Remacle
S A Shiryaev
V S Golubkov
P2860
P2888
P356
10.1038/ONCSIS.2013.44
P577
2013-12-02T00:00:00Z