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Application of locked nucleic acids to improve aptamer in vivo stability and targeting function

Application of locked nucleic acids to improve aptamer in vivo stability and targeting function

http://www.wikidata.org/entity/Q37619467

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Aptamers in Therapeutics Aptamers: A Feasible Technology in Cancer Immunotherapy Methods for Improving Aptamer Binding Affinity From selection hits to clinical leads: progress in aptamer discovery Molecular Selection, Modification and Development of Therapeutic Oligonucleotide Aptamers DNA Aptamers in the Diagnosis and Treatment of Human Diseases Nucleic Acid aptamers: new methods for selection, stabilization, and application in biomedical science Applications of aptamers in targeted imaging: state of the art The crystal structure of an 'All Locked' nucleic acid duplex G-rich VEGF aptamer with locked and unlocked nucleic acid modifications exhibits a unique G-quadruplex fold A regular thymine tetrad and a peculiar supramolecular assembly in the first crystal structure of an all-LNA G-quadruplex In vitro selection using a dual RNA library that allows primerless selection Exploring cellular activity of locked nucleic acid-modified triplex-forming oligonucleotides and defining its molecular basis.Selective delivery of therapeutic agents for the diagnosis and treatment of cancer.One-step selection of Vaccinia virus-binding DNA aptamers by MonoLEX Crystallization and preliminary X-ray diffraction data of an LNA 7-mer duplex derived from a ricin aptamer.Development of DNA aptamers using Cell-SELEX.Aptamers and the next generation of diagnostic reagents.Blocking interaction of viral gp120 and CD4-expressing T cells by single-stranded DNA aptamers.Chemical synthesis of LNA-2-thiouridine and its influence on stability and selectivity of oligonucleotide binding to RNA.Whole transcriptome analysis: what are we still missing?Aptamers from cell-based selection for bioanalytical applications Nucleic acid aptamers: clinical applications and promising new horizons Probing high affinity sequences of DNA aptamer against VEGF165 Amplification and re-generation of LNA-modified libraries.Design of growth factor sequestering biomaterials Activatable aptamer probe for contrast-enhanced in vivo cancer imaging based on cell membrane protein-triggered conformation alteration Aptamer photoregulation in vivo A multivalent DNA aptamer specific for the B-cell receptor on human lymphoma and leukemia Improved in situ hybridization efficiency with locked-nucleic-acid-incorporated DNA probes.Nucleic Acid Ligands With Protein-like Side Chains: Modified Aptamers and Their Use as Diagnostic and Therapeutic Agents Tenascin-C: Exploitation and collateral damage in cancer management Aptamers: new arrows to target dendritic cells.Aptamer technology for tracking cells' status & function.Post-SELEX optimization of aptamers.Evolution of Complex Target SELEX to Identify Aptamers against Mammalian Cell-Surface Antigens Comparative crystallization and preliminary X-ray diffraction studies of locked nucleic acid and RNA stems of a tenascin C-binding aptamer.Nanoparticle-aptamer bioconjugates for cancer targeting.Inhibition of aac(6')-Ib-mediated amikacin resistance by nuclease-resistant external guide sequences in bacteria Aptamers as theranostic agents: modifications, serum stability and functionalisation

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Application of locked nucleic acids to improve aptamer in vivo stability and targeting function

http://www.wikidata.org/entity/Q37619467

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 27 October 2004

@en

vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

@cs

name

Application of locked nucleic ...... ability and targeting function

@en

Application of locked nucleic ...... bility and targeting function.

@nl

type

label

Application of locked nucleic ...... ability and targeting function

@en

Application of locked nucleic ...... bility and targeting function.

@nl

prefLabel

Application of locked nucleic ...... ability and targeting function

@en

Application of locked nucleic ...... bility and targeting function.

@nl

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Nucleic Acids Research

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Application of locked nucleic ...... ability and targeting function

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Andrew W Stephens

http://www.w3.org/2001/XMLSchema#string

Jens Kurreck

http://www.w3.org/2001/XMLSchema#string

Kathrin S Schmidt

http://www.w3.org/2001/XMLSchema#string

Ludger Dinkelborg

http://www.w3.org/2001/XMLSchema#string

Maren Hecht

http://www.w3.org/2001/XMLSchema#string

Matthias Friebe

http://www.w3.org/2001/XMLSchema#string

Rolf Bald

http://www.w3.org/2001/XMLSchema#string

Sandra Borkowski

http://www.w3.org/2001/XMLSchema#string

Volker A Erdmann

http://www.w3.org/2001/XMLSchema#string

P2860

A tenascin-C aptamer identified by tumor cell SELEX: systematic evolution of ligands by exponential enrichment

Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase

Expanded sequence dependence of thermodynamic parameters improves prediction of RNA secondary structure

In vitro selection of RNA molecules that bind specific ligands

Emerging clinical applications of RNA

Aptamers: an emerging class of molecules that rival antibodies in diagnostics.

Selection and stabilization of the RNA aptamers against the human immunodeficiency virus type-1 nucleocapsid protein.

Spiegelmers: biostable aptamers.

Locked nucleic acid (LNA): fine-tuning the recognition of DNA and RNA.

Mirror-image RNA that binds D-adenosine.

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5757-5765

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scholarly article

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10.1093/NAR/GKH862

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19

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2004-10-27T00:00:00Z

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8207140

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15509871

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