Suppression of tumor angiogenesis by targeting the protein neddylation pathway. - Wikidata - wikimedia - TriplyDB

Suppression of tumor angiogenesis by targeting the protein neddylation pathway.

Suppression of tumor angiogenesis by targeting the protein neddylation pathway.

http://www.wikidata.org/entity/Q37620640

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Distinct outcomes of CRL-Nedd8 pathway inhibition reveal cancer cell plasticity Targeting the overexpressed ROC1 induces G2 cell cycle arrest and apoptosis in esophageal cancer cells Targeting cullin-RING ligases for cancer treatment: rationales, advances and therapeutic implications.Neddylation pathway is up-regulated in human intrahepatic cholangiocarcinoma and serves as a potential therapeutic target Prediction of neddylation sites from protein sequences and sequence-derived properties.Targeting protein neddylation with an NEDD8-activating enzyme inhibitor MLN4924 induced apoptosis or senescence in human lymphoma cells.MLN4924, a Novel NEDD8-activating enzyme inhibitor, exhibits antitumor activity and enhances cisplatin-induced cytotoxicity in human cervical carcinoma: in vitro and in vivo study.Regulator of cullins-1 expression knockdown suppresses the malignant progression of muscle-invasive transitional cell carcinoma by regulating mTOR/DEPTOR pathway.Neddylated Cullin 3 is required for vascular endothelial-cadherin-mediated endothelial barrier function.Screening for E3-ubiquitin ligase inhibitors: challenges and opportunities.MLN4924 therapy as a novel approach in cancer treatment modalities.Combinatorial Screening of Pancreatic Adenocarcinoma Reveals Sensitivity to Drug Combinations Including Bromodomain Inhibitor Plus Neddylation Inhibitor.Promoting tumorigenesis in nasopharyngeal carcinoma, NEDD8 serves as a potential theranostic target.MLN4924 sensitizes monocytes and maturing dendritic cells for TNF-dependent and -independent necroptosis.The CUL3-SPOP-DAXX axis is a novel regulator of VEGFR2 expression in vascular endothelial cells.Cullin-3 and its adaptor protein ANKFY1 determine the surface level of integrin β1 in endothelial cells.Inhibition of neddylation by MLN4924 improves neointimal hyperplasia and promotes apoptosis of vascular smooth muscle cells through p53 and p62.Protein neddylation and its alterations in human cancers for targeted therapy.MiR-378 and MiR-1827 Regulate Tumor Invasion, Migration and Angiogenesis in Human Lung Adenocarcinoma by Targeting RBX1 and CRKL, Respectively.The E3 Ubiquitin Ligase CRL4 Regulates Proliferation and Progression Through Meiosis in Chinese Mitten Crab Eriocheir sinensis.

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Suppression of tumor angiogenesis by targeting the protein neddylation pathway.

http://www.wikidata.org/entity/Q37620640

description

article científic

@ca

article scientifique

@fr

articolo scientifico

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artigo científico

@pt

bilimsel makale

@tr

scientific article published on 13 February 2014

@en

vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

@da

vědecký článek

@cs

name

Suppression of tumor angiogenesis by targeting the protein neddylation pathway.

@en

Suppression of tumor angiogenesis by targeting the protein neddylation pathway.

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type

label

Suppression of tumor angiogenesis by targeting the protein neddylation pathway.

@en

Suppression of tumor angiogenesis by targeting the protein neddylation pathway.

@nl

prefLabel

Suppression of tumor angiogenesis by targeting the protein neddylation pathway.

@en

Suppression of tumor angiogenesis by targeting the protein neddylation pathway.

@nl

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Cell Death and Disease

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Suppression of tumor angiogenesis by targeting the protein neddylation pathway.

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G-Y Yu

http://www.w3.org/2001/XMLSchema#string

H Cheng

http://www.w3.org/2001/XMLSchema#string

H Qi

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H W Lee

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H-Q Ying

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J Yu

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J-F Wu

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K Wang

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L S Jeong

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L-H Li

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P2860

Hallmarks of Cancer: The Next Generation

The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae

Cullin mediates degradation of RhoA through evolutionarily conserved BTB adaptors to control actin cytoskeleton structure and cell movement

Inhibition of NEDD8-conjugation pathway by novel molecules: potential approaches to anticancer therapy

Dcn1 functions as a scaffold-type E3 ligase for cullin neddylation

Substrate-assisted inhibition of ubiquitin-like protein-activating enzymes: the NEDD8 E1 inhibitor MLN4924 forms a NEDD8-AMP mimetic in situ

Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity

ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cells

FBW7 regulates endothelial functions by targeting KLF2 for ubiquitination and degradation

Ubiquitin E3 ligase CRL4(CDT2/DCAF2) as a potential chemotherapeutic target for ovarian surface epithelial cancer

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e1059

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scholarly article

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10.1038/CDDIS.2014.21

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5

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2014-02-13T00:00:00Z

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260195701

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24525735

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3944239

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