Nonsense-mediated mRNA decay in human cells: mechanistic insights, functions beyond quality control and the double-life of NMD factors.
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Non-structural protein 1 of influenza viruses inhibits rapid mRNA degradation mediated by double-stranded RNA-binding protein, staufen1DHX34 and NBAS form part of an autoregulatory NMD circuit that regulates endogenous RNA targets in human cells, zebrafish and Caenorhabditis elegansTel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexesCharacterization of SMG-9, an essential component of the nonsense-mediated mRNA decay SMG1C complexStringency of start codon selection modulates autoregulation of translation initiation factor eIF5Targeted capture and next-generation sequencing identifies C9orf75, encoding taperin, as the mutated gene in nonsyndromic deafness DFNB79SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decayAn unusual arrangement of two 14-3-3-like domains in the SMG5-SMG7 heterodimer is required for efficient nonsense-mediated mRNA decayHuman UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replicationIdentification and characterization of 15 novel GALC gene mutations causing Krabbe diseaseMechanism of escape from nonsense-mediated mRNA decay of human beta-globin transcripts with nonsense mutations in the first exonTracking and coordinating an international curation effort for the CCDS ProjectMechanism and regulation of the nonsense-mediated decay pathwayA unifying theory for general multigenic heterosis: energy efficiency, protein metabolism, and implications for molecular breedingThe Supraspliceosome - A Multi-Task Machine for Regulated Pre-mRNA Processing in the Cell NucleusNonsense-mediated mRNA decay: inter-individual variability and human diseasePhysiological basis of copper tolerance of Saccharomyces cerevisiae nonsense-mediated mRNA decay mutants.Nonsense-Mediated mRNA Decay: Degradation of Defective Transcripts Is Only Part of the StoryA combined proteomics/genomics approach links hepatitis C virus infection with nonsense-mediated mRNA decayCharacterization of Novel Ribosome-Associated Endoribonuclease SLFN14 from Rabbit ReticulocytesIntrons in UTRs: why we should stop ignoring themExclusion of exon 2 is a common mRNA splice variant of primate telomerase reverse transcriptasesPlakophilins 1 and 3 bind to FXR1 and thereby influence the mRNA stability of desmosomal proteinsPlakophilin-associated RNA-binding proteins in prostate cancer and their implications in tumor progression and metastasis.AluY-mediated germline deletion, duplication and somatic stem cell reversion in UBE2T defines a new subtype of Fanconi anemia.Alternative splicing mediates responses of the Arabidopsis circadian clock to temperature changes.A hypomorphic mutation in Lpin1 induces progressively improving neuropathy and lipodystrophy in the ratHIV-1 Recruits UPF1 but Excludes UPF2 to Promote Nucleocytoplasmic Export of the Genomic RNA.Aminoglycosides restore full-length type VII collagen by overcoming premature termination codons: therapeutic implications for dystrophic epidermolysis bullosa.RNA sequencing of synaptic and cytoplasmic Upf1-bound transcripts supports contribution of nonsense-mediated decay to epileptogenesis.A novel nonsense mutation in the MPL gene in congenital amegakaryocytic thrombocytopenia.Compound inheritance of a low-frequency regulatory SNP and a rare null mutation in exon-junction complex subunit RBM8A causes TAR syndrome.Contribution of copy number variants involving nonsense-mediated mRNA decay pathway genes to neuro-developmental disorders.Spliceosomal protein eftud2 mutation leads to p53-dependent apoptosis in zebrafish neural progenitors.Molecular cloning and characterization of the human ErbB4 gene: identification of novel splice isoforms in the developing and adult brainExpression proteomics of UPF1 knockdown in HeLa cells reveals autoregulation of hnRNP A2/B1 mediated by alternative splicing resulting in nonsense-mediated mRNA decay.Phosphatidylserine increases IKBKAP levels in familial dysautonomia cellsA short in-frame deletion in NTRK1 tyrosine kinase domain caused by a novel splice site mutation in a patient with congenital insensitivity to pain with anhidrosis.Frequent mutations in chromatin-remodelling genes in pulmonary carcinoids.When a ribosome encounters a premature termination codon.
P2860
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P2860
Nonsense-mediated mRNA decay in human cells: mechanistic insights, functions beyond quality control and the double-life of NMD factors.
description
article científic
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article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 27 October 2009
@en
vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Nonsense-mediated mRNA decay i ...... he double-life of NMD factors.
@en
Nonsense-mediated mRNA decay i ...... he double-life of NMD factors.
@nl
type
label
Nonsense-mediated mRNA decay i ...... he double-life of NMD factors.
@en
Nonsense-mediated mRNA decay i ...... he double-life of NMD factors.
@nl
prefLabel
Nonsense-mediated mRNA decay i ...... he double-life of NMD factors.
@en
Nonsense-mediated mRNA decay i ...... he double-life of NMD factors.
@nl
P2093
P50
P1476
Nonsense-mediated mRNA decay i ...... he double-life of NMD factors.
@en
P2093
Nicole Kleinschmidt
Rodolfo Zamudio Orozco
Stefanie Metze
P2888
P304
P356
10.1007/S00018-009-0177-1
P577
2009-10-27T00:00:00Z