Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B.
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Mutations in human AID differentially affect its ability to deaminate cytidine and 5-methylcytidine in ssDNA substrates in vitroStructural determinants of APOBEC3B non-catalytic domain for molecular assembly and catalytic regulationA Novel Regulator of Activation-Induced Cytidine Deaminase/APOBECs in Immunity and Cancer: Schrödinger's CATalytic Pocket.AID Recognizes Structured DNA for Class Switch Recombination.DNA mutagenic activity and capacity for HIV-1 restriction of the cytidine deaminase APOBEC3G depend on whether DNA or RNA binds to tyrosine 315.APOBEC3B lysine residues are dispensable for DNA cytosine deamination, HIV-1 restriction, and nuclear localization.Roles of APOBEC3A and APOBEC3B in Human Papillomavirus Infection and Disease Progression.Family-Wide Comparative Analysis of Cytidine and Methylcytidine Deamination by Eleven Human APOBEC Proteins.NMR-based method of small changes reveals how DNA mutator APOBEC3A interacts with its single-stranded DNA substrate.APOBEC3A efficiently deaminates methylated, but not TET-oxidized, cytosine bases in DNA.Influence of the DNA sequence/length and pH on deaminase activity, as well as the roles of the amino acid residues around the catalytic center of APOBEC3F.APOBEC Enzymes as Targets for Virus and Cancer Therapy.Molecular Interactions of a DNA Modifying Enzyme APOBEC3F Catalytic Domain with a Single-Stranded DNA.Conformational Switch Regulates the DNA Cytosine Deaminase Activity of Human APOBEC3B.Computational Model and Dynamics of Monomeric Full-Length APOBEC3G.Enzyme cycling contributes to efficient induction of genome mutagenesis by the cytidine deaminase APOBEC3B.The Antiviral and Cancer Genomic DNA Deaminase APOBEC3H Is Regulated by an RNA-Mediated Dimerization Mechanism.Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage.Differentiation-dependent antiviral capacities of amphibian (Xenopus laevis) macrophages.Mechanisms for targeted, purposeful mutation revealed in an APOBEC-DNA complex.APOBEC-mediated mutagenesis in urothelial carcinoma is associated with improved survival, mutations in DNA damage response genes, and immune response.Insights into DNA substrate selection by APOBEC3G from structural, biochemical, and functional studies.A fluorescent reporter for quantification and enrichment of DNA editing by APOBEC-Cas9 or cleavage by Cas9 in living cells.Diversification of AID/APOBEC-like deaminases in metazoa: multiplicity of clades and widespread roles in immunity.CRISPR base editors: genome editing without double-stranded breaks.Crystal structure of the catalytic domain of HIV-1 restriction factor APOBEC3G in complex with ssDNA.Substrate sequence selectivity of APOBEC3A implicates intra-DNA interactions.Modeling the Embrace of a Mutator: APOBEC Selection of Nucleic Acid LigandsAPOBEC3 Mediates Resistance to Oncolytic Viral TherapyAPOBEC3B Activity Is Prevalent in Urothelial Carcinoma Cells and Only Slightly Affected by LINE-1 ExpressionStrategy of Human Cytomegalovirus To Escape Interferon Beta-Induced APOBEC3G Editing Activity
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Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B.
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article científic
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artigo científico
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bilimsel makale
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scientific article published on 19 December 2016
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vetenskaplig artikel
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Structural basis for targeted ...... esis by APOBEC3A and APOBEC3B.
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Structural basis for targeted ...... esis by APOBEC3A and APOBEC3B.
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Structural basis for targeted ...... esis by APOBEC3A and APOBEC3B.
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Structural basis for targeted ...... esis by APOBEC3A and APOBEC3B.
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Structural basis for targeted ...... esis by APOBEC3A and APOBEC3B.
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Structural basis for targeted ...... esis by APOBEC3A and APOBEC3B.
@nl
P2093
P2860
P50
P356
P1476
Structural basis for targeted ...... esis by APOBEC3A and APOBEC3B.
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P2093
Daniel J Salamango
Gabriel J Starrett
Hideki Aihara
Jennifer L McCann
Justin V Duffy
Kayo Kurahashi
Nadine M Shaban
Reuben S Harris
Rommie E Amaro
P2860
P2888
P304
P356
10.1038/NSMB.3344
P577
2016-12-19T00:00:00Z