Loss of μ opioid receptor signaling in nociceptors, but not microglia, abrogates morphine tolerance without disrupting analgesia.
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Biphalin, a Dimeric Enkephalin, Alleviates LPS-Induced Activation in Rat Primary Microglial Cultures in Opioid Receptor-Dependent and Receptor-Independent Manners.Chemogenetic silencing of GABAergic dorsal horn interneurons induces morphine-resistant spontaneous nocifensive behaviours.Combining Human and Rodent Genetics to Identify New Analgesics.Nerve Decompression Improves Spinal Synaptic Plasticity of Opioid Receptors for Pain Relief.A "tail" of opioid receptor variants.Peripheral Interaction of Resolvin D1 and E1 with Opioid Receptor Antagonists for Antinociception in Inflammatory Pain in Rats.Morphine-induced hyperalgesia involves mu opioid receptors and the metabolite morphine-3-glucuronide.Usefulness of knockout mice to clarify the role of the opioid system in chronic pain.Therapies and mechanisms of opioid withdrawal.The gut-brain interaction in opioid tolerance.Connexin-purinergic signaling in enteric glia mediates the prolonged effect of morphine on constipation.Long-term morphine delivery via slow release morphine pellets or osmotic pumps: Plasma concentration, analgesia, and naloxone-precipitated withdrawal.Genetic dissociation of morphine analgesia from hyperalgesia in mice.Genetic deletion of microglial Panx1 attenuates morphine withdrawal, but not analgesic tolerance or hyperalgesia in mice.Fentanyl Induces Rapid Onset Hyperalgesic Priming: Type I at Peripheral and Type II at Central Nociceptor Terminals.Antinociception by the anti-oxidized phospholipid antibody E06.Inhibitory Gi/O-coupled receptors in somatosensory neurons: Potential therapeutic targets for novel analgesics.Peripherally Acting μ-Opioid Receptor Agonists Attenuate Ongoing Pain-associated Behavior and Spontaneous Neuronal Activity after Nerve Injury in Rats.Clinical opioids differentially induce co-internalization of μ- and δ-opioid receptors.Mu-opioid receptors in nociceptive afferents produce a sustained suppression of hyperalgesia in chronic pain.Ethanol Reversal of Oxycodone Tolerance in Dorsal Root Ganglia Neurons.Remifentanil-induced postoperative hyperalgesia: current perspectives on mechanisms and therapeutic strategies.Functional Divergence of Delta and Mu Opioid Receptor Organization in CNS Pain Circuits.Inhibition of Histone Deacetylases Attenuates Morphine Tolerance and Restores MOR Expression in the DRG of BCP Rats.Inner Workings: Safer opioids may be on the horizon, but mitigating addiction is a long shot
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P2860
Loss of μ opioid receptor signaling in nociceptors, but not microglia, abrogates morphine tolerance without disrupting analgesia.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 16 January 2017
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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Loss of μ opioid receptor sign ...... without disrupting analgesia.
@en
Loss of μ opioid receptor sign ...... without disrupting analgesia.
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type
label
Loss of μ opioid receptor sign ...... without disrupting analgesia.
@en
Loss of μ opioid receptor sign ...... without disrupting analgesia.
@nl
prefLabel
Loss of μ opioid receptor sign ...... without disrupting analgesia.
@en
Loss of μ opioid receptor sign ...... without disrupting analgesia.
@nl
P2093
P2860
P50
P356
P1433
P1476
Loss of μ opioid receptor sign ...... without disrupting analgesia.
@en
P2093
Ben A Barres
Chaudy Sotoudeh
Christopher J Bohlen
Gregory Corder
J David Clark
Jasmine R Dickinson
Sarah A Low
P2860
P2888
P304
P356
10.1038/NM.4262
P407
P577
2017-01-16T00:00:00Z