ROS-dependent activation of JNK converts p53 into an efficient inhibitor of oncogenes leading to robust apoptosis. - Wikidata - wikimedia - TriplyDB

ROS-dependent activation of JNK converts p53 into an efficient inhibitor of oncogenes leading to robust apoptosis.

ROS-dependent activation of JNK converts p53 into an efficient inhibitor of oncogenes leading to robust apoptosis.

http://www.wikidata.org/entity/Q37631181

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C-Jun N-terminal kinase signalling pathway in response to cisplatin DNA repair and aging: the impact of the p53 family JNK-NQO1 axis drives TAp73-mediated tumor suppression upon oxidative and proteasomal stress Noncanocial cell death program independent of caspase activation cascade and necroptotic modules is elicited by loss of TGFβ-activated kinase 1.The role of ROS and subsequent DNA-damage response in PUMA-induced apoptosis of ovarian cancer cells.Wild type p53 reactivation: from lab bench to clinic.The conserved Trp114 residue of thioredoxin reductase 1 has a redox sensor-like function triggering oligomerization and crosslinking upon oxidative stress related to cell death Primate Torpor: Regulation of Stress-activated Protein Kinases During Daily Torpor in the Gray Mouse Lemur, Microcebus murinus ROS-Induced JNK and p38 Signaling Is Required for Unpaired Cytokine Activation during Drosophila Regeneration Adenanthin targets peroxiredoxin I/II to kill hepatocellular carcinoma cells.3D tumor tissue analogs and their orthotopic implants for understanding tumor-targeting of microenvironment-responsive nanosized chemotherapy and radiation.Vitamin K2 Induces Mitochondria-Related Apoptosis in Human Bladder Cancer Cells via ROS and JNK/p38 MAPK Signal Pathways.ATM regulates cell fate choice upon p53 activation by modulating mitochondrial turnover and ROS levels.Anti-tumoral effect of desmethylclomipramine in lung cancer stem cells.Aryl Hydrocarbon Receptor Ligand 5F 203 Induces Oxidative Stress That Triggers DNA Damage in Human Breast Cancer Cells HSP27 Alleviates Cardiac Aging in Mice via a Mechanism Involving Antioxidation and Mitophagy Activation.JNK1/2 expression and modulation of STAT3 signaling in oral cancer.Activation of p53 in Down Syndrome and in the Ts65Dn Mouse Brain is Associated with a Pro-Apoptotic Phenotype.Structurally novel steroidal spirooxindole by241 potently inhibits tumor growth mainly through ROS-mediated mechanisms Integrin α5β1 and p53 convergent pathways in the control of anti-apoptotic proteins PEA-15 and survivin in high-grade glioma Metabolic pathways regulated by TAp73 in response to oxidative stress Impaired macrophage autophagy induces systemic insulin resistance in obesity Mycobacterium avium MAV2054 protein induces macrophage apoptosis by targeting mitochondria and reduces intracellular bacterial growth.Induction of Bex genes by curcumin is associated with apoptosis and activation of p53 in N2a neuroblastoma cells.A steroid like phytochemical Antcin M is an anti-aging reagent that eliminates hyperglycemia-accelerated premature senescence in dermal fibroblasts by direct activation of Nrf2 and SIRT-1.Resveratrol changes spermatogonial stem cells (SSCs) activity and ameliorates their loss in busulfan-induced infertile mouse.Altered Mitochondrial Signalling and Metabolism in Cancer.Chemo- and bioinformatics resources for in silico drug discovery from medicinal plants beyond their traditional use: a critical review.Miltirone exhibits antileukemic activity by ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction pathways.Nujiangexathone A, a Novel Compound Derived from Garcinia nujiangensis, Induces Caspase-Dependent Apoptosis in Cervical Cancer through the ROS/JNK Pathway.Peptides and peptidomimetics in the p53/MDM2/MDM4 circuitry - a patent review.RITA can induce cell death in p53-defective cells independently of p53 function via activation of JNK/SAPK and p38.RLIP76 Inhibition: A Promising Developmental Therapy for Neuroblastoma.Correlation between Oxidative Stress, Nutrition, and Cancer Initiation.Guggulsterone-induced apoptosis in cholangiocarcinoma cells through ROS/JNK signaling pathway The Role of the MAPK Signaling, Topoisomerase and Dietary Bioactives in Controlling Cancer Incidence Enpp1 is an anti-aging factor that regulates Klotho under phosphate overload conditions.2,4,6-Trinitrotoluene Induces Apoptosis via ROS-Regulated Mitochondrial Dysfunction and Endoplasmic Reticulum Stress in HepG2 and Hep3B Cells.Curcumin enhances the antitumor effect of ABT-737 via activation of the ROS-ASK1-JNK pathway in hepatocellular carcinoma cells.The p53 tetramer shows an induced-fit interaction of the C-terminal domain with the DNA-binding domain.

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ROS-dependent activation of JNK converts p53 into an efficient inhibitor of oncogenes leading to robust apoptosis.

http://www.wikidata.org/entity/Q37631181

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article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 10 January 2014

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

ROS-dependent activation of JN ...... s leading to robust apoptosis.

@en

ROS-dependent activation of JN ...... s leading to robust apoptosis.

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type

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ROS-dependent activation of JN ...... s leading to robust apoptosis.

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ROS-dependent activation of JN ...... s leading to robust apoptosis.

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prefLabel

ROS-dependent activation of JN ...... s leading to robust apoptosis.

@en

ROS-dependent activation of JN ...... s leading to robust apoptosis.

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ROS-dependent activation of JN ...... es leading to robust apoptosis

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A Kel

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E Hedström

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F Nikulenkov

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P2860

Wild-type p53-induced phosphatase 1 dephosphorylates histone variant gamma-H2AX and suppresses DNA double strand break repair

MDM2-dependent downregulation of p21 and hnRNP K provides a switch between apoptosis and growth arrest induced by pharmacologically activated p53

p53-mediated senescence impairs the apoptotic response to chemotherapy and clinical outcome in breast cancer.

Rapid induction of cell death by selenium-compromised thioredoxin reductase 1 but not by the fully active enzyme containing selenocysteine

Blinded by the Light: The Growing Complexity of p53

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

Transcriptional control of human p53-regulated genes

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612-623

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scholarly article

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10.1038/CDD.2013.186

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4

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21

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Razif R Gabdoulline

Galina Selivanova

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259698865

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