Conserved residues in yeast initiator tRNA calibrate initiation accuracy by regulating preinitiation complex stability at the start codon.
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An extended Shine-Dalgarno sequence in mRNA functionally bypasses a vital defect in initiator tRNA.Structural changes enable start codon recognition by the eukaryotic translation initiation complex.Human eukaryotic initiation factor 2 (eIF2)-GTP-Met-tRNAi ternary complex and eIF3 stabilize the 43 S preinitiation complex.Conformational changes in the P site and mRNA entry channel evoked by AUG recognition in yeast translation preinitiation complexesThe β-hairpin of 40S exit channel protein Rps5/uS7 promotes efficient and accurate translation initiation in vivo.Conformational Differences between Open and Closed States of the Eukaryotic Translation Initiation Complex.Ribosome Structure Reveals Preservation of Active Sites in the Presence of a P-Site Wobble MismatchMechanism and Regulation of Protein Synthesis in Saccharomyces cerevisiae.Structure of a 30S pre-initiation complex stalled by GE81112 reveals structural parallels in bacterial and eukaryotic protein synthesis initiation pathwaysRps3/uS3 promotes mRNA binding at the 40S ribosome entry channel and stabilizes preinitiation complexes at start codons.Is the cellular initiation of translation an exclusive property of the initiator tRNAs?eIF1A residues implicated in cancer stabilize translation preinitiation complexes and favor suboptimal initiation sites in yeast.eIF1 Loop 2 interactions with Met-tRNAi control the accuracy of start codon selection by the scanning preinitiation complex.Two highly conserved features of bacterial initiator tRNAs license them to pass through distinct checkpoints in translation initiation.
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Conserved residues in yeast initiator tRNA calibrate initiation accuracy by regulating preinitiation complex stability at the start codon.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on March 2014
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Conserved residues in yeast in ...... stability at the start codon.
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Conserved residues in yeast in ...... stability at the start codon.
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Conserved residues in yeast in ...... stability at the start codon.
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Conserved residues in yeast in ...... stability at the start codon.
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Conserved residues in yeast in ...... stability at the start codon.
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Conserved residues in yeast in ...... stability at the start codon.
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P2093
P2860
P356
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P1476
Conserved residues in yeast in ...... stability at the start codon.
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P2093
Alan G Hinnebusch
Antonio Munoz
Hafsa Rahman
Jinsheng Dong
Sarah E Kolitz
Wen-ling Chiu
P2860
P304
P356
10.1101/GAD.236547.113
P577
2014-03-01T00:00:00Z