Dynamics: the missing link between structure and function of the viral RNA-dependent RNA polymerase?
about
Using the Hepatitis C Virus RNA-Dependent RNA Polymerase as a Model to Understand Viral Polymerase Structure, Function and DynamicsStructural dynamics as a contributor to error-prone replication by an RNA-dependent RNA polymerase.Structure of the RNA-directed RNA Polymerase from the cystovirus ϕ12Structure of a backtracked state reveals conformational changes similar to the state following nucleotide incorporation in human norovirus polymeraseSequence-Specific Fidelity Alterations Associated with West Nile Virus Attenuation in MosquitoesInitiation of RNA synthesis by the hepatitis C virus RNA-dependent RNA polymerase is affected by the structure of the RNA template.Dynamics on multiple timescales in the RNA-directed RNA polymerase from the cystovirus phi6RNA virus population diversity, an optimum for maximal fitness and virulence.What is the role of motif D in the nucleotide incorporation catalyzed by the RNA-dependent RNA polymerase from poliovirus?Molecular dynamics simulations of viral RNA polymerases link conserved and correlated motions of functional elements to fidelityStructural Analysis of Monomeric RNA-Dependent Polymerases: Evolutionary and Therapeutic ImplicationsMolecular dynamics simulation in virus research.Dengue virus nonstructural protein 5 adopts multiple conformations in solution.Highly similar structural frames link the template tunnel and NTP entry tunnel to the exterior surface in RNA-dependent RNA polymerases.Long-Range Communication between Different Functional Sites in the Picornaviral 3C Protein.Methyl Relaxation Measurements Reveal Patterns of Fast Dynamics in a Viral RNA-Directed RNA PolymeraseNorovirus RNA-dependent RNA polymerase: A computational study of metal-binding preferences.Cystoviral RNA-directed RNA polymerases: Regulation of RNA synthesis on multiple time and length scales.Molecular simulations to delineate functional conformational transitions in the HCV polymerase.Conformational Ensemble of the Poliovirus 3CD Precursor Observed by MD Simulations and Confirmed by SAXS: A Strategy to Expand the Viral Proteome?Identification of two essential aspartates for polymerase activity in parainfluenza virus L protein by a minireplicon system expressing secretory luciferase.Long-range interaction networks in the function and fidelity of poliovirus RNA-dependent RNA polymerase studied by nuclear magnetic resonance.Slow conformational dynamics in the cystoviral RNA-directed RNA polymerase P2: influence of substrate nucleotides and template RNA.Changes in protein domains outside the catalytic site of the bacteriophage Qβ replicase reduce the mutagenic effect of 5-azacytidine.Exploring the dynamics of four RNA-dependent RNA polymerases by a coarse-grained model.A computational approach for predicting off-target toxicity of antiviral ribonucleoside analogues to mitochondrial RNA polymerase.
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Dynamics: the missing link between structure and function of the viral RNA-dependent RNA polymerase?
description
2009 nî lūn-bûn
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2009年の論文
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2009年学术文章
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2009年学术文章
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2009年学术文章
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2009年学术文章
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2009年学术文章
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name
Dynamics: the missing link bet ...... RNA-dependent RNA polymerase?
@en
Dynamics: the missing link bet ...... RNA-dependent RNA polymerase?
@nl
type
label
Dynamics: the missing link bet ...... RNA-dependent RNA polymerase?
@en
Dynamics: the missing link bet ...... RNA-dependent RNA polymerase?
@nl
prefLabel
Dynamics: the missing link bet ...... RNA-dependent RNA polymerase?
@en
Dynamics: the missing link bet ...... RNA-dependent RNA polymerase?
@nl
P2860
P1476
Dynamics: the missing link bet ...... RNA-dependent RNA polymerase?
@en
P2093
Ibrahim M Moustafa
Jamie J Arnold
P2860
P304
P356
10.1016/J.SBI.2009.10.012
P577
2009-11-10T00:00:00Z