Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers
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Apolipoprotein J (clusterin) activates rodent microglia in vivo and in vitroCommon Alzheimer's disease risk variant within the CLU gene affects white matter microstructure in young adultsAfamin is synthesized by cerebrovascular endothelial cells and mediates alpha-tocopherol transport across an in vitro model of the blood-brain barrierApolipoproteins E and J interfere with amyloid-beta uptake by primary human astrocytes and microglia in vitroSelective interaction of megalin with postsynaptic density-95 (PSD-95)-like membrane-associated guanylate kinase (MAGUK) proteinsCytosolic adaptor protein Dab2 is an intracellular ligand of endocytic receptor gp600/megalinGenome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's diseaseGenome-wide association studies in Alzheimer's diseaseMechanisms of Aβ Clearance and Degradation by Glial CellsPathophysiology of the neurovascular unit: disease cause or consequence?Inflammation and Alzheimer's diseaseOlive-oil-derived oleocanthal enhances β-amyloid clearance as a potential neuroprotective mechanism against Alzheimer's disease: in vitro and in vivo studiesClusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer's diseaseDiffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxinsInteraction of apolipoprotein J-amyloid beta-peptide complex with low density lipoprotein receptor-related protein-2/megalin. A mechanism to prevent pathological accumulation of amyloid beta-peptide.Lymphatics in Neurological Disorders: A Neuro-Lympho-Vascular Component of Multiple Sclerosis and Alzheimer's Disease?Phagocytic clearance in neurodegeneration.PET imaging of leptin biodistribution and metabolism in rodents and primates.Systemic amyloid deposits in familial British dementia.Systemic catabolism of Alzheimer's Abeta40 and Abeta42.Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous systemGenetics and molecular pathogenesis of sporadic and hereditary cerebral amyloid angiopathiesThe p75 neurotrophin receptor localization in blood-CSF barrier: expression in choroid plexus epitheliumLipoproteins in the central nervous system.Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrierAbeta immunization: moving Abeta peptide from brain to bloodApolipoprotein E gene promoter polymorphisms in Alzheimer's disease.Replication of CLU, CR1, and PICALM associations with alzheimer disease.LRP in Alzheimer's disease: friend or foe?Agile delivery of protein therapeutics to CNSMegalin and cubilin: synergistic endocytic receptors in renal proximal tubule.Low-density lipoprotein receptor-related protein-1: a serial clearance homeostatic mechanism controlling Alzheimer's amyloid β-peptide elimination from the brainPlasma apolipoprotein levels are associated with cognitive status and decline in a community cohort of older individuals.Clusterin protects H9c2 cardiomyocytes from oxidative stress-induced apoptosis via Akt/GSK-3β signaling pathway.Apolipoproteins in the brain: implications for neurological and psychiatric disorders.Caffeine protects against disruptions of the blood-brain barrier in animal models of Alzheimer's and Parkinson's diseases.Clearance of amyloid-beta peptide across the blood-brain barrier: implication for therapies in Alzheimer's disease.Intravenously injected human apolipoprotein A-I rapidly enters the central nervous system via the choroid plexus.Amyloid-beta transporter expression at the blood-CSF barrier is age-dependent.Neurovascular defects and faulty amyloid-β vascular clearance in Alzheimer's disease
P2860
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P2860
Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on April 1996
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Glycoprotein 330/megalin: prob ...... d-cerebrospinal fluid barriers
@en
Glycoprotein 330/megalin: prob ...... -cerebrospinal fluid barriers.
@nl
type
label
Glycoprotein 330/megalin: prob ...... d-cerebrospinal fluid barriers
@en
Glycoprotein 330/megalin: prob ...... -cerebrospinal fluid barriers.
@nl
prefLabel
Glycoprotein 330/megalin: prob ...... d-cerebrospinal fluid barriers
@en
Glycoprotein 330/megalin: prob ...... -cerebrospinal fluid barriers.
@nl
P2093
P2860
P356
P1476
Glycoprotein 330/megalin: prob ...... d-cerebrospinal fluid barriers
@en
P2093
B Frangione
B V Zlokovic
C L Martel
E Matsubara
J G McComb
R T McCluskey
P2860
P304
P356
10.1073/PNAS.93.9.4229
P407
P577
1996-04-01T00:00:00Z