about
Macrophage-specific inhibition of NF-kappaB activation reduces foam-cell formationGenetics of the human metabolome, what is next?New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes riskAutomated workflow-based exploitation of pathway databases provides new insights into genetic associations of metabolite profilesEstimation of activity related energy expenditure and resting metabolic rate in freely moving mice from indirect calorimetry dataA genome-wide association search for type 2 diabetes genes in African AmericansThe role of body mass index, insulin, and adiponectin in the relation between fat distribution and bone mineral density.Improving the analysis of designed studies by combining statistical modelling with study design informationGenome-wide mRNA expression analysis of hepatic adaptation to high-fat diets reveals switch from an inflammatory to steatotic transcriptional program.Prenatal exposure to apoE deficiency and postnatal hypercholesterolemia are associated with altered cell-specific lysine methyltransferase and histone methylation patterns in the vasculature.Genetic architecture of plasma adiponectin overlaps with the genetics of metabolic syndrome-related traits.Clear detection of ADIPOQ locus as the major gene for plasma adiponectin: results of genome-wide association analyses including 4659 European individualsHigh levels of dietary stearate promote adiposity and deteriorate hepatic insulin sensitivity.High fat diet-induced changes in mouse muscle mitochondrial phospholipids do not impair mitochondrial respiration despite insulin resistance.Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.Znf202 affects high density lipoprotein cholesterol levels and promotes hepatosteatosis in hyperlipidemic mice.Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels.Association of adiponectin and leptin with relative telomere length in seven independent cohorts including 11,448 participants.Carbohydrate metabolism is perturbed in peroxisome-deficient hepatocytes due to mitochondrial dysfunction, AMP-activated protein kinase (AMPK) activation, and peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) suppression.Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.The suprachiasmatic nucleus controls circadian energy metabolism and hepatic insulin sensitivity.Practical aspects of estimating energy components in rodents.MIF deficiency reduces chronic inflammation in white adipose tissue and impairs the development of insulin resistance, glucose intolerance, and associated atherosclerotic disease.CETP does not affect triglyceride production or clearance in APOE*3-Leiden mice.Heritability of dietary food intake patterns.Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance.Skeletal muscle mitochondrial uncoupling, adaptive thermogenesis and energy expenditure.Reanalysis of mGWAS results and in vitro validation show that lactate dehydrogenase interacts with branched-chain amino acid metabolism.Intrauterine exposure to maternal atherosclerotic risk factors increases the susceptibility to atherosclerosis in adult life.Caspase-1 deficiency in mice reduces intestinal triglyceride absorption and hepatic triglyceride secretion.Very-low-density lipoprotein binding to the apolipoprotein E receptor 2 is enhanced by lipoprotein lipase, and does not require apolipoprotein E.Fenofibrate increases very low density lipoprotein triglyceride production despite reducing plasma triglyceride levels in APOE*3-Leiden.CETP mice.CD36 is important for adipocyte recruitment and affects lipolysis.Perfluoroalkyl sulfonates cause alkyl chain length-dependent hepatic steatosis and hypolipidemia mainly by impairing lipoprotein production in APOE*3-Leiden CETP mice.An 8-week high-fat diet induces obesity and insulin resistance with small changes in the muscle transcriptome of C57BL/6J mice.Downregulation of the acetyl-CoA metabolic network in adipose tissue of obese diabetic individuals and recovery after weight loss.Effects of prolonged fasting on AMPK signaling, gene expression, and mitochondrial respiratory chain content in skeletal muscle from lean and obese individuals.VLDL receptor deficiency enhances intimal thickening after vascular injury but does not affect atherosclerotic lesion area.META060 protects against diet-induced obesity and insulin resistance in a high-fat-diet fed mouse.ApoC-III deficiency prevents hyperlipidemia induced by apoE overexpression.
P50
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description
Hochschullehrer
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Universiteit onderwyser
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academydd
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dosen
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hulumtues
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profesor universitario
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professeur d'université
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professore universitario
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researcher
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universitetslärare
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name
J.A.P. Willems van Dijk
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J.A.P. Willems van Dijk
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J.A.P. Willems van Dijk
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J.A.P. Willems van Dijk
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J.A.P. Willems van Dijk
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J.A.P. Willems van Dijk
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J.A.P. Willems van Dijk
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J.A.P. Willems van Dijk
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J.A.P. Willems van Dijk
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J.A.P. Willems van Dijk
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type
label
J.A.P. Willems van Dijk
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J.A.P. Willems van Dijk
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J.A.P. Willems van Dijk
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J.A.P. Willems van Dijk
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J.A.P. Willems van Dijk
@de
J.A.P. Willems van Dijk
@es
J.A.P. Willems van Dijk
@fi
J.A.P. Willems van Dijk
@fr
J.A.P. Willems van Dijk
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J.A.P. Willems van Dijk
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J.A.P. Willems van Dijk
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J.A.P. Willems van Dijk
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J.A.P. Willems van Dijk
@cy
J.A.P. Willems van Dijk
@da
J.A.P. Willems van Dijk
@de
J.A.P. Willems van Dijk
@es
J.A.P. Willems van Dijk
@fi
J.A.P. Willems van Dijk
@fr
J.A.P. Willems van Dijk
@id
J.A.P. Willems van Dijk
@it
P1053
A-1798-2008
P1153
7005701009
P21
P2798
P31
P3829
P496
0000-0002-2172-7394
P569
2000-01-01T00:00:00Z