The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
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The genetics of platelet count and volume in humans.The impact of rare and low-frequency genetic variants in common diseaseGenome-wide association study of red blood cell traits in Hispanics/Latinos: The Hispanic Community Health Study/Study of Latinos.SNP in human ARHGEF3 promoter is associated with DNase hypersensitivity, transcript level and platelet function, and Arhgef3 KO mice have increased mean platelet volume.Genetic-epigenetic interactions in cis: a major focus in the post-GWAS eraPlatelet function is modified by common sequence variation in megakaryocyte super enhancersGenetic regulatory effects modified by immune activation contribute to autoimmune disease associations.Genome-wide association of white blood cell counts in Hispanic/Latino Americans: the Hispanic Community Health Study/Study of Latinos.Diagnosis of inherited bleeding disorders in the genomic era.Immunogenomic approaches to understand the function of immune disease variants.GATA Factor-Regulated Samd14 Enhancer Confers Red Blood Cell Regeneration and Survival in Severe Anemia.Rare coding variants pinpoint genes that control human hematological traits.An erythroid-specific ATP2B4 enhancer mediates red blood cell hydration and malaria susceptibility.Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms.Red blood cell distribution width: Genetic evidence for aging pathways in 116,666 volunteers.Nbeal2 interacts with Dock7, Sec16a, and Vac14.Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology.Challenges in understanding common disease.Statistical methods to detect pleiotropy in human complex traits.Concise Review: Epigenetic Regulation of Hematopoiesis: Biological Insights and Therapeutic Applications.Recent Developments in Mendelian Randomization Studies.Genetic architecture: the shape of the genetic contribution to human traits and disease.Blocking protein quality control to counter hereditary cancers.ACTN1 variants associated with thrombocytopenia.High-throughput sequencing approaches for diagnosing hereditary bleeding and platelet disorders.TUBB1 variants and human platelet traits.High-throughput sequencing for rapid diagnosis of inherited platelet disorders: a case for a European consensus.Advances in transfusion medicine RCPath, November 2016.Human longevity: 25 genetic loci associated in 389,166 UK biobank participants.Identification of novel hyper- or hypomethylated CpG sites and genes associated with atherosclerotic plaque using an epigenome-wide association study.Item-level analyses reveal genetic heterogeneity in neuroticism.An analytical framework for whole-genome sequence association studies and its implications for autism spectrum disorder.Survey and evaluation of mutations in the human KLF1 transcription unit.Global analysis of A-to-I RNA editing reveals association with common disease variants.Methods for fine-mapping with chromatin and expression data.Big data from electronic health records for early and late translational cardiovascular research: challenges and potential.Signatures of Long-Term Balancing Selection in Human Genomes.Autoimmune-Mediated Thymic Atrophy Is Accelerated but Reversible in RelB-Deficient Mice.Red blood cell indices and anaemia as causative factors for cognitive function deficits and for Alzheimer's disease.Genetic-Driven Druggable Target Identification and Validation
P2860
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P2860
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年学术文章
@wuu
2016年学术文章
@zh-cn
2016年学术文章
@zh-hans
2016年学术文章
@zh-my
2016年学术文章
@zh-sg
2016年學術文章
@yue
2016年學術文章
@zh
2016年學術文章
@zh-hant
name
The Allelic Landscape of Human ...... nks to Common Complex Disease.
@en
The Allelic Landscape of Human ...... nks to Common Complex Disease.
@nl
type
label
The Allelic Landscape of Human ...... nks to Common Complex Disease.
@en
The Allelic Landscape of Human ...... nks to Common Complex Disease.
@nl
prefLabel
The Allelic Landscape of Human ...... nks to Common Complex Disease.
@en
The Allelic Landscape of Human ...... nks to Common Complex Disease.
@nl
P2093
P2860
P50
P1433
P1476
The Allelic Landscape of Human ...... nks to Common Complex Disease.
@en
P2093
Amit Mandoli
Anita Kaan
Carmel Moore
Dace Ruklisa
Dave Allen
David Bujold
David Juan
Emanuele Di Angelantonio
P2860
P304
1415-1429.e19
P356
10.1016/J.CELL.2016.10.042
P407
P50
P577
2016-11-01T00:00:00Z