Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor. - Wikidata - wikimedia - TriplyDB

Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor.

Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor.

http://www.wikidata.org/entity/Q37635711

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Design, synthesis and bioevaluation of an EphA2 receptor-based targeted delivery system.UniPR129 is a competitive small molecule Eph-ephrin antagonist blocking in vitro angiogenesis at low micromolar concentrations.Comparative Analysis of Virtual Screening Approaches in the Search for Novel EphA2 Receptor Antagonists.Deletion of the EphA2 receptor exacerbates myocardial injury and the progression of ischemic cardiomyopathy Eph receptors and ephrins: therapeutic opportunities.Synthesis and structure-activity relationships of amino acid conjugates of cholanic acid as antagonists of the EphA2 receptor.Target hopping as a useful tool for the identification of novel EphA2 protein-protein antagonists.Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2.Reduction of Circulating Cancer Cells and Metastases in Breast-Cancer Models by a Potent EphA2-Agonistic Peptide-Drug Conjugate.Exploiting Free-Energy Minima to Design Novel EphA2 Protein-Protein Antagonists: From Simulation to Experiment and Return.UniPR1331, a small molecule targeting Eph/ephrin interaction, prolongs survival in glioblastoma and potentiates the effect of antiangiogenic therapy in mice.Eph/Ephrin-mediated stimulation of human bone marrow mesenchymal stromal cells correlates with changes in cell adherence and increased cell death.Deciphering the role of hydrophobic and hydrophilic bile acids in angiogenesis using and model systems The Apoptosis Effect on Liver Cancer Cells of Gold Nanoparticles Modified with Lithocholic Acid

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Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor.

http://www.wikidata.org/entity/Q37635711

description

article científic

@ca

article scientifique

@fr

articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 22 March 2013

@en

vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

@cs

name

Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor.

@en

Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor.

@nl

type

label

Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor.

@en

Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor.

@nl

prefLabel

Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor.

@en

Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor.

@nl

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Journal of Medicinal Chemistry

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Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor

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Carmine Giorgio

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Elena B Pasquale

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Elisabetta Barocelli

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Iftiin Hassan-Mohamed

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Matteo Incerti

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Paola Vicini

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Silvia Piersanti

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Simonetta Russo

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P2860

Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation

Ligand recognition by A-class Eph receptors: crystal structures of the EphA2 ligand-binding domain and the EphA2/ephrin-A1 complex

Ephs and ephrins in cancer: ephrin-A1 signalling

Fragment based lead discovery of small molecule inhibitors for the EPHA4 receptor tyrosine kinase

Ectodomain structures of Eph receptors

Regulation of angiogenesis by Eph-ephrin interactions

Separation of methylated free bile acids from their taurine and methyl glycine conjugates by thin-layer chromatography

Lithocholic acid is an Eph-ephrin ligand interfering with Eph-kinase activation

Reaching for high-hanging fruit in drug discovery at protein-protein interfaces

New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays

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2936-2947

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scholarly article

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10.1021/JM301890K

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7

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56

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Massimiliano Tognolini

Roberta Noberini

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2013-03-22T00:00:00Z

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236045206

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23489211

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