PRIMA-1 targets the vulnerability of multiple myeloma of deregulated protein homeostasis through the perturbation of ER stress via p73 demethylation. - Wikidata - wikimedia - TriplyDB

PRIMA-1 targets the vulnerability of multiple myeloma of deregulated protein homeostasis through the perturbation of ER stress via p73 demethylation.

PRIMA-1 targets the vulnerability of multiple myeloma of deregulated protein homeostasis through the perturbation of ER stress via p73 demethylation.

http://www.wikidata.org/entity/Q37641688

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Molecular Mechanisms of p53 Deregulation in Cancer: An Overview in Multiple Myeloma TFDP3 confers chemoresistance in minimal residual disease within childhood T-cell acute lymphoblastic leukemia.Reviving the guardian of the genome: Small molecule activators of p53.Association of P73 polymorphisms with susceptibilities of cervical carcinoma: a meta-analysis.Decitabine and Melphalan Fail to Reactivate p73 in p53 Deficient Myeloma Cells.PRIMA-1 and PRIMA-1Met (APR-246): From Mutant/Wild Type p53 Reactivation to Unexpected Mechanisms Underlying Their Potent Anti-Tumor Effect in Combinatorial Therapies.Integrin-β4 is a novel transcriptional target of TAp73.Potent anti-tumor activity of a syringolin analog in multiple myeloma: a dual inhibitor of proteasome activity targeting β2 and β5 subunits.

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PRIMA-1 targets the vulnerability of multiple myeloma of deregulated protein homeostasis through the perturbation of ER stress via p73 demethylation.

http://www.wikidata.org/entity/Q37641688

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 12 August 2016

@en

vedecký článok

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vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

PRIMA-1 targets the vulnerabil ...... stress via p73 demethylation.

@en

PRIMA-1 targets the vulnerabil ...... stress via p73 demethylation.

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type

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PRIMA-1 targets the vulnerabil ...... stress via p73 demethylation.

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PRIMA-1 targets the vulnerabil ...... stress via p73 demethylation.

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prefLabel

PRIMA-1 targets the vulnerabil ...... stress via p73 demethylation.

@en

PRIMA-1 targets the vulnerabil ...... stress via p73 demethylation.

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ONCOTARGET.11241

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PRIMA-1 targets the vulnerabil ...... stress via p73 demethylation.

@en

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Chirackal Sintosebastian

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Chonglei Bi

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Liang Seah Tay

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Phaik Ju Teoh

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Rafael Fonseca

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Wee Joo Chng

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P2860

Plasma cell differentiation requires the transcription factor XBP-1

Blockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myeloma

Current and emerging treatment options for patients with relapsed myeloma

Clinical significance of TP53 mutation in myeloma.

Proteasome inhibitors disrupt the unfolded protein response in myeloma cells

Upregulating Noxa by ER stress, celastrol exerts synergistic anti-cancer activity in combination with ABT-737 in human hepatocellular carcinoma cells

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound.

Methods for monitoring endoplasmic reticulum stress and the unfolded protein response.

Mutations in TP53 are exclusively associated with del(17p) in multiple myeloma

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scholarly article

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10.18632/ONCOTARGET.11241

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2016-08-12T00:00:00Z

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