The PINK1/Parkin pathway: a mitochondrial quality control system?
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Parkinson's disease-associated kinase PINK1 regulates Miro protein level and axonal transport of mitochondriaPINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motilityMitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagyp62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for bothMitochondrial trafficking in neuronsHow Parkinsonian toxins dysregulate the autophagy machineryBioenergetic consequences of PINK1 mutations in Parkinson diseaseMutations in the mitochondrial methionyl-tRNA synthetase cause a neurodegenerative phenotype in flies and a recessive ataxia (ARSAL) in humansDrosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusinPINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65Bioenergetics of neurons inhibit the translocation response of Parkin following rapid mitochondrial depolarization.PINK1-mediated phosphorylation of Miro inhibits synaptic growth and protects dopaminergic neurons in DrosophilaParkin-mediated selective mitochondrial autophagy, mitophagy: Parkin purges damaged organelles from the vital mitochondrial network.A pivotal role for PINK1 and autophagy in mitochondrial quality control: implications for Parkinson disease.Recent advances in the genetics of Parkinson's disease.HIV-1 Vpr triggers mitochondrial destruction by impairing Mfn2-mediated ER-mitochondria interaction.Overexpression of parkin ameliorates dopaminergic neurodegeneration induced by 1- methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice.Mitochondrial-nuclear epistasis: implications for human aging and longevity.PINK1 and Parkin to control mitochondria remodeling.Parkin ubiquitinates Drp1 for proteasome-dependent degradation: implication of dysregulated mitochondrial dynamics in Parkinson diseasemtDNA Mutations and Their Role in Aging, Diseases and Forensic SciencesNMR Metabolomics Analysis of Parkinson's DiseaseGenetic analysis in Drosophila reveals a role for the mitochondrial protein p32 in synaptic transmissionMitochondrial Ca(2+) and neurodegenerationCaenorhabditis elegans as a model system to study intercompartmental proteostasis: Interrelation of mitochondrial function, longevity, and neurodegenerative diseases.Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue.Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespanMitophagy and Parkinson's disease: the PINK1-parkin link.Gene therapy: a viable therapeutic strategy for Parkinson's disease?Mitochondrial contribution to Parkinson's disease pathogenesis.Mitochondrial pathology in Parkinson's disease.The meaning of mitochondrial movement to a neuron's lifeMitochondrial dynamics: the intersection of form and function.Function and characteristics of PINK1 in mitochondria.Recent advances in Parkinson’s disease genetics.Mitochondrial dysfunctions in neurodegenerative diseases: relevance to Alzheimer's disease.How mitochondrial dynamism orchestrates mitophagy.Age-related accumulation of phosphorylated mitofusin 2 protein in retinal ganglion cells correlates with glaucoma progression.Functional Impairment in Miro Degradation and Mitophagy Is a Shared Feature in Familial and Sporadic Parkinson's Disease.The cellular basis of dendrite pathology in neurodegenerative diseases.
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The PINK1/Parkin pathway: a mitochondrial quality control system?
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
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scientific article published on December 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
The PINK1/Parkin pathway: a mitochondrial quality control system?
@en
The PINK1/Parkin pathway: a mitochondrial quality control system?
@nl
type
label
The PINK1/Parkin pathway: a mitochondrial quality control system?
@en
The PINK1/Parkin pathway: a mitochondrial quality control system?
@nl
prefLabel
The PINK1/Parkin pathway: a mitochondrial quality control system?
@en
The PINK1/Parkin pathway: a mitochondrial quality control system?
@nl
P1476
The PINK1/Parkin pathway: a mitochondrial quality control system?
@en
P2093
Leo J Pallanck
P2888
P304
P356
10.1007/S10863-009-9253-3
P577
2009-12-01T00:00:00Z