MGMT promoter methylation in malignant gliomas: ready for personalized medicine?
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New perspectives in glioblastoma antiangiogenic therapyAdvances in the treatment of newly diagnosed glioblastomaO(6)-methylguanine-DNA methyltransferase in glioma therapy: promise and problemsToward a Molecular Classification of Colorectal Cancer: The Role of MGMTDNA methylation biomarkers: cancer and beyondActivity of 2-aryl-2-(3-indolyl)acetohydroxamates against drug-resistant cancer cells.The prognostic value of MGMT promoter status by pyrosequencing assay for glioblastoma patients' survival: a meta-analysisMolecular heterogeneity in glioblastoma: potential clinical implicationsMiR-221/222 target the DNA methyltransferase MGMT in glioma cellsThe future role of personalized medicine in the treatment of glioblastoma multiformeFluorogenic Real-Time Reporters of DNA Repair by MGMT, a Clinical Predictor of Antitumor Drug ResponseDW-MRI as a biomarker to compare therapeutic outcomes in radiotherapy regimens incorporating temozolomide or gemcitabine in glioblastomaPrognostic value of three different methods of MGMT promoter methylation analysis in a prospective trial on newly diagnosed glioblastomaAssessing CpG island methylator phenotype, 1p/19q codeletion, and MGMT promoter methylation from epigenome-wide data in the biomarker cohort of the NOA-04 trial.Identifying core gene modules in glioblastoma based on multilayer factor-mediated dysfunctional regulatory networks through integrating multi-dimensional genomic data.Clinical applications of iron oxide nanoparticles for magnetic resonance imaging of brain tumors.Performance evaluation of kits for bisulfite-conversion of DNA from tissues, cell lines, FFPE tissues, aspirates, lavages, effusions, plasma, serum, and urine.Temozolomide and pasireotide treatment for aggressive pituitary adenoma: expertise at a tertiary care center.Demethylating Agents in the Treatment of CancerDetection of circulating tumor cells in the cerebrospinal fluid of a patient with a solitary metastasis from breast cancer: A case reportThe rs16906252:C>T SNP is not associated with increased overall survival or temozolomide response in a Han-Chinese glioma cohort.Gliomas in adults.Systematic cross-validation of 454 sequencing and pyrosequencing for the exact quantification of DNA methylation patterns with single CpG resolutionComprehensive analysis of MGMT promoter methylation: correlation with MGMT expression and clinical response in GBMO6-Methylguanine-DNA methyltransferase protein expression by immunohistochemistry in brain and non-brain systemic tumours: systematic review and meta-analysis of correlation with methylation-specific polymerase chain reaction.Recurrent high-grade glioma: a diagnostic and therapeutic challenge.Ependymoma stem cells are highly sensitive to temozolomide in vitro and in orthotopic models.Molecular targeting of glioblastoma: Drug discovery and therapiesEvolution of malignant glioma treatment: from chemotherapy to vaccines to viruses.Review: molecular pathology in adult high-grade gliomas: from molecular diagnostics to target therapiesCorrelation of IDH1 mutation with clinicopathologic factors and prognosis in primary glioblastoma: a report of 118 patients from ChinaOverview of cellular immunotherapy for patients with glioblastoma.Targeting DNA repair proteins for cancer treatmentDissecting DNA repair in adult high grade gliomas for patient stratification in the post-genomic era.Integration of autologous dendritic cell-based immunotherapy in the standard of care treatment for patients with newly diagnosed glioblastoma: results of the HGG-2006 phase I/II trial.ATM regulates 3-methylpurine-DNA glycosylase and promotes therapeutic resistance to alkylating agents.DNA methyltransferases, DNA damage repair, and cancerSurgical resection of malignant gliomas-role in optimizing patient outcome.Tumour heterogeneity in the clinic.Regulation of expression of O6-methylguanine-DNA methyltransferase and the treatment of glioblastoma (Review).
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MGMT promoter methylation in malignant gliomas: ready for personalized medicine?
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 08 December 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
MGMT promoter methylation in malignant gliomas: ready for personalized medicine?
@en
MGMT promoter methylation in malignant gliomas: ready for personalized medicine?
@nl
type
label
MGMT promoter methylation in malignant gliomas: ready for personalized medicine?
@en
MGMT promoter methylation in malignant gliomas: ready for personalized medicine?
@nl
prefLabel
MGMT promoter methylation in malignant gliomas: ready for personalized medicine?
@en
MGMT promoter methylation in malignant gliomas: ready for personalized medicine?
@nl
P2093
P50
P1476
MGMT promoter methylation in malignant gliomas: ready for personalized medicine?
@en
P2093
Alba A Brandes
Martin J van den Bent
Monika E Hegi
Roger Stupp
P2888
P356
10.1038/NRNEUROL.2009.197
P407
P577
2009-12-08T00:00:00Z