Role of reactive metabolites in drug-induced hepatotoxicity.
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Acetaminophen-induced Liver Injury: from Animal Models to HumansEvidence-based selection of training compounds for use in the mechanism-based integrated prediction of drug-induced liver injury in manRelationship between structural alerts in NSAIDs and idiosyncratic hepatotoxicity: an analysis of spontaneous report data from the WHO database.Real-time imaging of oxidative and nitrosative stress in the liver of live animals for drug-toxicity testing.The Simplest Flowchart Stating the Mechanisms for Organic Xenobiotics-induced Toxicity: Can it Possibly be Accepted as a "Central Dogma" for Toxic Mechanisms?Identification of the Additional Mitochondrial Liabilities of 2-Hydroxyflutamide When Compared With its Parent Compound, Flutamide in HepG2 Cells.M1 muscarinic receptors modify oxidative stress response to acetaminophen-induced acute liver injury.Time course of acetaminophen-protein adducts and acetaminophen metabolites in circulation of overdose patients and in HepaRG cells.Triptolide Induces hepatotoxicity via inhibition of CYP450s in Rat liver microsomes.Molecular mechanisms underlying chemical liver injury.TRPM2 channels mediate acetaminophen-induced liver damageDeleterious effects of reactive metabolites.Antituberculosis drugs: drug interactions, adverse effects, and use in special situations. Part 1: first-line drugs.Drug and metabolite concentrations in tissues in relationship to tissue adverse findings: a review.Drug-induced liver injury: a summary of recent advances.A review of the use of in silico methods to predict the chemistry of molecular initiating events related to drug toxicity.Hepatotoxicity of tyrosine kinase inhibitors: clinical and regulatory perspectives.Hepatotoxicity: a scheme for generating chemical categories for read-across, structural alerts and insights into mechanism(s) of action.Formation of reactive metabolites and management of tyrosine kinase inhibitor-induced hepatotoxicity: a literature review.An overview on the proposed mechanisms of antithyroid drugs-induced liver injury.Metabolic activation and drug-induced liver injury: in vitro approaches for the safety risk assessment of new drugs.Development of HepG2-derived cells expressing cytochrome P450s for assessing metabolism-associated drug-induced liver toxicity.Effect of CYP3A4 inducer dexamethasone on hepatotoxicity of lapatinib: clinical and in vitro evidence.Real-Time In Vivo Hepatotoxicity Monitoring through Chromophore-Conjugated Photon-Upconverting Nanoprobes.A Disposable Microfluidic Device with a Screen Printed Electrode for Mimicking Phase II Metabolism.Lycium barbarum extract provides effective protection against paracetamol-induced acute hepatotoxicity in rats.In vitro evidence for bakuchiol's influence towards drug metabolism through inhibition of UDP-glucuronosyltransferase (UGT) 2B7.Potential protective effects of oral administration of allicin on acrylamide-induced toxicity in male mice.Therapeutic effect of liposomal-N-acetylcysteine against acetaminophen-induced hepatotoxicity.Evaluation of DILI Predictive Hypotheses in Early Drug Development.In vivo assessment of intracellular redox state in rat liver using hyperpolarized [1-13 C]Alanine.Customised in vitro model to detect human metabolism-dependent idiosyncratic drug-induced liver injury.A Model to predict severity of drug-induced liver injury in humans.Characterization of human cytochrome P450 mediated bioactivation of amodiaquine and its major metabolite N-desethylamodiaquine.Hepatocyte spheroids as a competent in vitro system for drug biotransformation studies: nevirapine as a bioactivation case study.Glutathione S-Transferase P1 Protects Against Amodiaquine Quinoneimines-Induced Cytotoxicity but Does Not Prevent Activation of Endoplasmic Reticulum Stress in HepG2 Cells.Dissecting the molecular pathophysiology of drug-induced liver injury.
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P2860
Role of reactive metabolites in drug-induced hepatotoxicity.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on January 2010
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Role of reactive metabolites in drug-induced hepatotoxicity.
@en
Role of reactive metabolites in drug-induced hepatotoxicity.
@nl
type
label
Role of reactive metabolites in drug-induced hepatotoxicity.
@en
Role of reactive metabolites in drug-induced hepatotoxicity.
@nl
prefLabel
Role of reactive metabolites in drug-induced hepatotoxicity.
@en
Role of reactive metabolites in drug-induced hepatotoxicity.
@nl
P2093
P1476
Role of reactive metabolites in drug-induced hepatotoxicity.
@en
P2093
A Srivastava
D J Antoine
D P Williams
P304
P356
10.1007/978-3-642-00663-0_7
P577
2010-01-01T00:00:00Z