The keap1-nrf2 cellular defense pathway: mechanisms of regulation and role in protection against drug-induced toxicity.
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Mechanisms of chemical-induced innate immunity in allergic contact dermatitis.Small molecule modulators of Keap1-Nrf2-ARE pathway as potential preventive and therapeutic agentsImplementation of a high-throughput screen for identifying small molecules to activate the Keap1-Nrf2-ARE pathwayInflammatory Stress Sensitizes the Liver to Atorvastatin-Induced Injury in ApoE-/- MiceModulation of proteostasis by transcription factor NRF2 and impact in neurodegenerative diseasesFeeding of selenium alone or in combination with glucoraphanin differentially affects intestinal and hepatic antioxidant and phase II enzymes in growing rats.Nrf2 upregulates ATP binding cassette transporter expression and activity at the blood-brain and blood-spinal cord barriersChallenging oneself intermittently to improve health.Structure-activity relationship of capsaicin analogs and transient receptor potential vanilloid 1-mediated human lung epithelial cell toxicity.Activation of Keap1/Nrf2 signaling pathway by nuclear epidermal growth factor receptor in cancer cells.Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy.Green tea polyphenol (-)-epigallocatechin-3-gallate restores Nrf2 activity and ameliorates crescentic glomerulonephritis18β-Glycyrrhetinic acid exerts protective effects against cyclophosphamide-induced hepatotoxicity: potential role of PPARγ and Nrf2 upregulationComparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and Detoxication.The Relevance of Nrf2 Pathway and Autophagy in Pancreatic Cancer Cells upon Stimulation of Reactive Oxygen Species.Molecular mechanisms underlying chemical liver injury.In vitro and in vivo characterization of a tunable dual-reactivity probe of the Nrf2-ARE pathwayReporter protein complementation imaging assay to screen and study Nrf2 activators in cells and living animals.Managing the challenge of chemically reactive metabolites in drug development.Therapeutic potential of green tea in nonalcoholic fatty liver disease.Regulation of drug-induced liver injury by signal transduction pathways: critical role of mitochondria.Natural antioxidants in the treatment and prevention of diabetic nephropathy; a potential approach that warrants clinical trials.Breakdown products of neoglucobrassicin inhibit activation of Nrf2 target genes mediated by myrosinase-derived glucoraphanin hydrolysis products.Nuclear factor-erythroid 2 (NF-E2) p45-related factor-2 (Nrf2) modulates dendritic cell immune function through regulation of p38 MAPK-cAMP-responsive element binding protein/activating transcription factor 1 signaling.Nrf2 deficiency prevents reductive stress-induced hypertrophic cardiomyopathy.Pluripotent Stem Cell-Derived Human Tissue: Platforms to Evaluate Drug Metabolism and Safety.The Role of Free Radicals in Autophagy Regulation: Implications for Ageing.Protective effects of BML-111 on cerulein-induced acute pancreatitis-associated lung injury via activation of Nrf2/ARE signaling pathway.NRF2 regulates the glutamine transporter Slc38a3 (SNAT3) in kidney in response to metabolic acidosis.
P2860
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P2860
The keap1-nrf2 cellular defense pathway: mechanisms of regulation and role in protection against drug-induced toxicity.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on January 2010
@en
vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
The keap1-nrf2 cellular defens ...... against drug-induced toxicity.
@en
The keap1-nrf2 cellular defens ...... against drug-induced toxicity.
@nl
type
label
The keap1-nrf2 cellular defens ...... against drug-induced toxicity.
@en
The keap1-nrf2 cellular defens ...... against drug-induced toxicity.
@nl
prefLabel
The keap1-nrf2 cellular defens ...... against drug-induced toxicity.
@en
The keap1-nrf2 cellular defens ...... against drug-induced toxicity.
@nl
P2093
P1476
The keap1-nrf2 cellular defens ...... against drug-induced toxicity
@en
P2093
B Kevin Park
Christopher E Goldring
Neil R Kitteringham
P304
P356
10.1007/978-3-642-00663-0_9
P50
P577
2010-01-01T00:00:00Z