Ablation of the oncogenic transcription factor ERG by deubiquitinase inhibition in prostate cancer. - Wikidata - wikimedia - TriplyDB

Ablation of the oncogenic transcription factor ERG by deubiquitinase inhibition in prostate cancer.

Ablation of the oncogenic transcription factor ERG by deubiquitinase inhibition in prostate cancer.

http://www.wikidata.org/entity/Q37660030

about

Regulation of endothelial homeostasis, vascular development and angiogenesis by the transcription factor ERG Emerging Role of Genomic Rearrangements in Breast Cancer: Applying Knowledge from Other Cancers Matrin3: connecting gene expression with the nuclear matrix Targeting the ubiquitin pathway for cancer treatment Targeting the adaptive molecular landscape of castration-resistant prostate cancer La FAM fatale: USP9X in development and disease Deubiquitinase inhibition by WP1130 leads to ULK1 aggregation and blockade of autophagy USP9X regulates centrosome duplication and promotes breast carcinogenesis.Context-dependent function of the deubiquitinating enzyme USP9X in pancreatic ductal adenocarcinoma Molecular pathways and targets in prostate cancer EPI-001 is a selective peroxisome proliferator-activated receptor-gamma modulator with inhibitory effects on androgen receptor expression and activity in prostate cancer The ETS family of oncogenic transcription factors in solid tumours.Deubiquitinases in cancer.Combined inhibition of Bcl-2/Bcl-xL and Usp9X/Bag3 overcomes apoptotic resistance in glioblastoma in vitro and in vivo.Role of Angiomotin-like 2 mono-ubiquitination on YAP inhibition.Molecular profiling of low grade serous ovarian tumours identifies novel candidate driver genes.TIC10/ONC201 synergizes with Bcl-2/Bcl-xL inhibition in glioblastoma by suppression of Mcl-1 and its binding partners in vitro and in vivo.Inhibition of deubiquitinases primes glioblastoma cells to apoptosis in vitro and in vivo.USP9X stabilizes XIAP to regulate mitotic cell death and chemoresistance in aggressive B-cell lymphoma.Arginine methylation of USP9X promotes its interaction with TDRD3 and its anti-apoptotic activities in breast cancer cells.USP9X destabilizes pVHL and promotes cell proliferation.The ubiquitin ligase TRIM25 targets ERG for degradation in prostate cancer.Androgen receptor and gene network: Micromechanics reassemble the signaling machinery of TMPRSS2-ERG positive prostate cancer cells.The oncogene ERG: a key factor in prostate cancer.Systematic enrichment analysis of potentially functional regions for 103 prostate cancer risk-associated loci.Decision for cell fate: deubiquitinating enzymes in cell cycle checkpoint.The X-linked deubiquitinase USP9X is an integral component of centrosome.Development of Peptidomimetic Inhibitors of the ERG Gene Fusion Product in Prostate Cancer.SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression.Drug discovery in advanced prostate cancer: translating biology into therapy.Targeting Deubiquitinating Enzymes in Glioblastoma Multiforme: Expectations and Challenges.Crosstalk of the Androgen Receptor with Transcriptional Collaborators: Potential Therapeutic Targets for Castration-Resistant Prostate Cancer The Spliceosomal Protein SF3B5 is a Novel Component of Drosophila SAGA that Functions in Gene Expression Independent of Splicing.Usp9x regulates Ets-1 ubiquitination and stability to control NRAS expression and tumorigenicity in melanoma.Discovery and characterization of small molecules targeting the DNA-binding ETS domain of ERG in prostate cancer.Suppressors and activators of JAK-STAT signaling at diagnosis and relapse of acute lymphoblastic leukemia in Down syndrome.Ethnicity and ERG frequency in prostate cancer.Usp9x Promotes Survival in Human Pancreatic Cancer and Its Inhibition Suppresses Pancreatic Ductal Adenocarcinoma In Vivo Tumor Growth.USP9X controls translation efficiency via deubiquitination of eukaryotic translation initiation factor 4A1.Stabilization of the methyl-CpG binding protein ZBTB38 by the deubiquitinase USP9X limits the occurrence and toxicity of oxidative stress in human cells.

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Ablation of the oncogenic transcription factor ERG by deubiquitinase inhibition in prostate cancer.

http://www.wikidata.org/entity/Q37660030

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 03 March 2014

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vedecký článok

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vetenskaplig artikel

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vědecký článek

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name

Ablation of the oncogenic tran ...... inhibition in prostate cancer.

@en

Ablation of the oncogenic tran ...... inhibition in prostate cancer.

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type

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Ablation of the oncogenic tran ...... inhibition in prostate cancer.

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Ablation of the oncogenic tran ...... inhibition in prostate cancer.

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Ablation of the oncogenic tran ...... inhibition in prostate cancer.

@en

Ablation of the oncogenic tran ...... inhibition in prostate cancer.

@nl

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PNAS.1322198111

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Proceedings of the National Academy of Sciences of the United States of America

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Ablation of the oncogenic tran ...... inhibition in prostate cancer.

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Caroline G Humphries

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Elizabeth Hernandez

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Eva Freeman

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Ganesh V Raj

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Jer-Tsong Hsieh

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Ladan Fazli

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Martin E Gleave

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Nishi Srivastava

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Payal Kapur

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Preethi Ravindranathan

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P2860

Androgen receptor variants occur frequently in castration resistant prostate cancer metastases

Mechanistic rationale for inhibition of poly(ADP-ribose) polymerase in ETS gene fusion-positive prostate cancer

An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression

A transcriptional repressor co-regulatory network governing androgen response in prostate cancers

The Ras target AF-6 is a substrate of the fam deubiquitinating enzyme

Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer.

Cancer statistics, 2012

Characterization of ERG, AR and PTEN gene status in circulating tumor cells from patients with castration-resistant prostate cancer.

Oncogenic ETS proteins mimic activated RAS/MAPK signaling in prostate cells.

Activation of a novel Bcr/Abl destruction pathway by WP1130 induces apoptosis of chronic myelogenous leukemia cells

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scholarly article

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10.1073/PNAS.1322198111

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11

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111

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2014-03-03T00:00:00Z

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260486365

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3964108

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