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Modulating polo-like kinase 1 as a means for cancer chemoprevention

Modulating polo-like kinase 1 as a means for cancer chemoprevention

http://www.wikidata.org/entity/Q37682665

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Plants vs. cancer: a review on natural phytochemicals in preventing and treating cancers and their druggability Targeting prostate cancer cell lines with polo-like kinase 1 inhibitors as a single agent and in combination with histone deacetylase inhibitors Polo-box domain inhibitor poloxin activates the spindle assembly checkpoint and inhibits tumor growth in vivo.The Catalytic Subunit of DNA-Dependent Protein Kinase Coordinates with Polo-Like Kinase 1 to Facilitate Mitotic Entry.Let's huddle to prevent a muddle: centrosome declustering as an attractive anticancer strategy.PLK1-associated microRNAs are correlated with pediatric medulloblastoma prognosis.Inhibition of polo-like kinase 1 induces cell cycle arrest and sensitizes glioblastoma cells to ionizing radiation.RNAi-mediated knockdown of MCM7 gene on CML cells and its therapeutic potential for leukemia.Polo-like kinase 1 as target for cancer therapy.Volasertib Enhances Sensitivity to TRAIL in Renal Carcinoma Caki Cells through Downregulation of c-FLIP Expression.Polo-like kinase 1 inhibition results in misaligned chromosomes and aberrant spindles in porcine oocytes during the first meiotic division.Occurrence of Aurora A positive multipolar mitoses in distinct molecular classes of colorectal carcinomas and effect of Aurora A inhibition.

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Modulating polo-like kinase 1 as a means for cancer chemoprevention

http://www.wikidata.org/entity/Q37682665

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article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 27 January 2010

@en

vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

@cs

name

Modulating polo-like kinase 1 as a means for cancer chemoprevention

@en

Modulating polo-like kinase 1 as a means for cancer chemoprevention.

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type

label

Modulating polo-like kinase 1 as a means for cancer chemoprevention

@en

Modulating polo-like kinase 1 as a means for cancer chemoprevention.

@nl

prefLabel

Modulating polo-like kinase 1 as a means for cancer chemoprevention

@en

Modulating polo-like kinase 1 as a means for cancer chemoprevention.

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S11095-010-0051-8

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Pharmaceutical Research

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Modulating polo-like kinase 1 as a means for cancer chemoprevention

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Nihal Ahmad

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Travis L Schmit

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P2860

Polo-like kinase-1 controls Aurora A destruction by activating APC/C-Cdh1

Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells

Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome

Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC Inhibitor Emi1

Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery

Plk1 regulates mitotic Aurora A function through betaTrCP-dependent degradation of hBora

Plk is an M-phase-specific protein kinase and interacts with a kinesin-like protein, CHO1/MKLP-1

Multitargeted therapy of cancer by silymarin

Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

BI 6727, a Polo-like kinase inhibitor with improved pharmacokinetic profile and broad antitumor activity

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10.1007/S11095-010-0051-8

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