Bcl-2 protein family expression pattern determines synergistic pro-apoptotic effects of BH3 mimetics with hemisynthetic cardiac glycoside UNBS1450 in acute myeloid leukemia.

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The Forty-Sixth Euro Congress on Drug Synthesis and Analysis: Snapshot †.Anticancer and Immunogenic Properties of Cardiac Glycosides.Micro-Economics of Apoptosis in Cancer: ncRNAs Modulation of BCL-2 Family Members.

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Bcl-2 protein family expression pattern determines synergistic pro-apoptotic effects of BH3 mimetics with hemisynthetic cardiac glycoside UNBS1450 in acute myeloid leukemia.

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2016 nî lūn-bûn

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2016年の論文

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2016年学术文章

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2016年学术文章

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2016年学术文章

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2016年学术文章

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2016年学术文章

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2016年學術文章

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Bcl-2 protein family expressio ...... 450 in acute myeloid leukemia.

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Bcl-2 protein family expressio ...... 450 in acute myeloid leukemia.

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Bcl-2 protein family expressio ...... 450 in acute myeloid leukemia.

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Bcl-2 protein family expressio ...... 450 in acute myeloid leukemia.

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Bcl-2 protein family expressio ...... 450 in acute myeloid leukemia.

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Bcl-2 protein family expressio ...... 450 in acute myeloid leukemia.

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Bcl-2 protein family expressio ...... 1450 in acute myeloid leukemia

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A Gaigneaux

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A Mazumder

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C Récher

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E Saland

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F Radogna

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H Y Shin

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J-E Sarry

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J-Y Lee

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K-W Kim

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M Dicato

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P2860

The fast-mobility isoform of mouse Mcl-1 is a mitochondrial matrix-localized protein with attenuated anti-apoptotic activity

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

Early downregulation of Mcl-1 regulates apoptosis triggered by cardiac glycoside UNBS1450

BCL2/BCL-X(L) inhibition induces apoptosis, disrupts cellular calcium homeostasis, and prevents platelet activation.

Selective BCL-2 inhibition by ABT-199 causes on-target cell death in acute myeloid leukemia.

Apoptosis-based therapies for hematologic malignancies.

Drug-induced death signaling strategy rapidly predicts cancer response to chemotherapy.

Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax).

Mcl-1 involvement in mitochondrial dynamics is associated with apoptotic cell death

BH3 profiling identifies heterogeneous dependency on Bcl-2 family members in multiple myeloma and predicts sensitivity to BH3 mimetics.

P2888

leu.2016.341

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755-759

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scholarly article

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10.1038/LEU.2016.341

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Marc Diederich

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2016-11-22T00:00:00Z

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apoptotic process

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Bcl-2 protein family expression pattern determines synergistic pro-apoptotic effects of BH3 mimetics with hemisynthetic cardiac glycoside UNBS1450 in acute myeloid leukemia.

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P2860

P2860

Bcl-2 protein family expression pattern determines synergistic pro-apoptotic effects of BH3 mimetics with hemisynthetic cardiac glycoside UNBS1450 in acute myeloid leukemia.

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