Progesterone receptor assembly of a transcriptional complex along with activator protein 1, signal transducer and activator of transcription 3 and ErbB-2 governs breast cancer growth and predicts response to endocrine therapy.
about
Posttranslationally modified progesterone receptors direct ligand-specific expression of breast cancer stem cell-associated gene programsCyclin A2 and its associated kinase activity are required for optimal induction of progesterone receptor target genes in breast cancer cellsProgesterone receptor activation downregulates GATA3 by transcriptional repression and increased protein turnover promoting breast tumor growthHigh basal Wnt signaling is further induced by PI3K/mTor inhibition but sensitive to cSRC inhibition in mammary carcinoma cell lines with HER2/3 overexpression.The unique transcriptional response produced by concurrent estrogen and progesterone treatment in breast cancer cells results in upregulation of growth factor pathways and switching from a Luminal A to a Basal-like subtypeCell surface GRP78: A potential marker of good prognosis and response to chemotherapy in breast cancerThe HER2 Signaling Network in Breast Cancer--Like a Spider in its Web.Stat3 regulates ErbB-2 expression and co-opts ErbB-2 nuclear function to induce miR-21 expression, PDCD4 downregulation and breast cancer metastasis.Stromal markers AKR1C1 and AKR1C2 are prognostic factors in primary human breast cancer.Targeting ErbB-2 nuclear localization and function inhibits breast cancer growth and overcomes trastuzumab resistance.Endocrine Resistance in Breast Cancer
P2860
Q33568421-50DE8045-9D0A-4D36-8C14-92ADADF5A87DQ34362853-4FC43BE2-A5E7-49BB-8474-BC42D24BB924Q35000657-72348C08-CA55-4744-A502-149C7ABBD446Q35709435-F549BE3D-E539-4577-9879-E45AE9D26A7CQ35820376-CFF046FC-6F0B-4275-8E7A-109FD203E140Q36085418-0C6F48E2-DAE9-4EBE-A6DF-57EB235E9B3DQ38302045-2D2DB8C0-87C2-4534-9FC1-A6CE1B3C4281Q38849205-7ECFCA9B-C049-4BBE-8DCF-E23FDFE84609Q53275913-4698831C-0EF6-45A1-B7F9-A481A34F6F39Q55071512-C5A34375-7B72-4191-B5B4-4A8D27E9EFE8Q59072640-0A197C8B-83B0-4CD9-BED1-CF9E086D19C3
P2860
Progesterone receptor assembly of a transcriptional complex along with activator protein 1, signal transducer and activator of transcription 3 and ErbB-2 governs breast cancer growth and predicts response to endocrine therapy.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 17 December 2013
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Progesterone receptor assembly ...... response to endocrine therapy.
@en
Progesterone receptor assembly ...... response to endocrine therapy.
@nl
type
label
Progesterone receptor assembly ...... response to endocrine therapy.
@en
Progesterone receptor assembly ...... response to endocrine therapy.
@nl
prefLabel
Progesterone receptor assembly ...... response to endocrine therapy.
@en
Progesterone receptor assembly ...... response to endocrine therapy.
@nl
P2093
P2860
P50
P356
P1476
Progesterone receptor assembly ...... response to endocrine therapy.
@en
P2093
Eduardo H Charreau
Esteban Maronna
María C Díaz Flaqué
María Mercogliano
Mercedes Tkach
Natalia M Galigniana
Pablo Guzmán
Rocío Vicario
Rosalía Russo
Sergio Muñoz
P2860
P2888
P356
10.1186/BCR3587
P50
P577
2013-12-17T00:00:00Z
P5875
P6179
1003123366