HTRF: A technology tailored for drug discovery - a review of theoretical aspects and recent applications.
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High density lipoproteins: Measurement techniques and potential biomarkers of cardiovascular riskCardiac cAMP: production, hydrolysis, modulation and detectionTools for GPCR drug discovery.Development of a Rapid Insulin Assay by Homogenous Time-Resolved FluorescenceHomogeneous agglutination assay based on micro-chip sheathless flow cytometry.High-throughput screening for modulators of protein-protein interactions: use of photonic crystal biosensors and complementary technologies.Two High Throughput Screen Assays for Measurement of TNF-α in THP-1 CellsDiscovery of novel aromatase inhibitors using a homogeneous time-resolved fluorescence assay.Development of a high-throughput screening method for LIM kinase 1 using a luciferase-based assay of ATP consumption.Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFβ interactionA small molecule inhibitor of Pot1 binding to telomeric DNA.Synthesis and optical properties of macrocyclic lanthanide(III) chelates as new reagents for luminescent biolabeling.New in silico and conventional in vitro approaches to advance HIV drug discovery and design.CANDLES, an assay for monitoring GPCR induced cAMP generation in cell cultures.Identification of raloxifene as a novel CB2 inverse agonist.Evaluation of AaDOP2 receptor antagonists reveals antidepressants and antipsychotics as novel lead molecules for control of the yellow fever mosquito, Aedes aegypti.A time-resolved fluorescence resonance energy transfer assay for high-throughput screening of 14-3-3 protein-protein interaction inhibitorsDevelopment of a high-throughput screening paradigm for the discovery of small-molecule modulators of adenylyl cyclase: identification of an adenylyl cyclase 2 inhibitor.G protein-coupled receptor signaling analysis using homogenous time-resolved Förster resonance energy transfer (HTRF®) technologyProlonged calcitonin receptor signaling by salmon, but not human calcitonin, reveals ligand bias.Motor neuron disease. SMN2 splicing modifiers improve motor function and longevity in mice with spinal muscular atrophy.Cell-based protein stabilization assays for the detection of interactions between small-molecule inhibitors and BRD4.Protein-protein interaction modulator drug discovery: past efforts and future opportunities using a rich source of low- and high-throughput screening assays.Fluorescence lifetime plate reader: resolution and precision meet high-throughputPolyglutamine- and temperature-dependent conformational rigidity in mutant huntingtin revealed by immunoassays and circular dichroism spectroscopyStabilization of G protein-coupled receptors by point mutations.Development and application of PI3K assays for novel drug discovery.Development of a CERT START Domain-Ceramide HTRF Binding Assay and Application to Pharmacological Studies and Screening.Recent developments in cell-based assays and stem cell technologies for botulinum neurotoxin research and drug discoveryRecent Advances on Luminescent Enhancement-Based Porous Silicon Biosensors.Investigation of prolactin receptor activation and blockade using time-resolved fluorescence resonance energy transferHyper sensitive protein detection by Tandem-HTRF reveals Cyclin D1 dynamics in adult mouseHTRF: a technology tailored for biomarker determination-novel analytical detection system suitable for detection of specific autoimmune antibodies as biomarkers in nanogram level in different body fluidsCharacterization of 12 GnRH peptide agonists - a kinetic perspectiveFlotation Immunoassay: Masking the Signal from Free Reporters in Sandwich ImmunoassaysAllosteric modulation and functional selectivity of G protein-coupled receptors.11β-hydroxysteroid dehydrogenase inhibition as a new potential therapeutic target for alcohol abuseTime-gated FRET nanoassemblies for rapid and sensitive intra- and extracellular fluorescence imagingAn adaptable luminescence resonance energy transfer assay for measuring and screening protein-protein interactions and their inhibition.A cell-free approach to accelerate the study of protein-protein interactions in vitro.
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HTRF: A technology tailored for drug discovery - a review of theoretical aspects and recent applications.
description
article científic
@ca
article scientifique
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articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 28 May 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
@cs
name
HTRF: A technology tailored fo ...... pects and recent applications.
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HTRF: A technology tailored fo ...... pects and recent applications.
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type
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HTRF: A technology tailored fo ...... pects and recent applications.
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HTRF: A technology tailored fo ...... pects and recent applications.
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HTRF: A technology tailored fo ...... pects and recent applications.
@en
HTRF: A technology tailored fo ...... pects and recent applications.
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P2093
P2860
P1476
HTRF: A technology tailored fo ...... pects and recent applications.
@en
P2093
Eric Trinquet
François Degorce
Glenn P Knapik
Sharon Soh
P2860
P356
10.2174/1875397300903010022
P577
2009-05-28T00:00:00Z