Synthesis of a 2-aryl-3-aroyl indole salt (OXi8007) resembling combretastatin A-4 with application as a vascular disrupting agent
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Palladium-Catalyzed Catellani ortho-Acylation Reaction: An Efficient and Regiospecific Synthesis of Diaryl Ketones.Dynamic bioluminescence and fluorescence imaging of the effects of the antivascular agent Combretastatin-A4P (CA4P) on brain tumor xenografts.Evaluation of tumor ischemia in response to an indole-based vascular disrupting agent using BLI and (19)F MRI.Mechanistic Considerations in the Synthesis of 2-Aryl-Indole Analogues under Bischler-Mohlau ConditionsThe vascular disrupting activity of OXi8006 in endothelial cells and its phosphate prodrug OXi8007 in breast tumor xenografts.Structural interrogation of benzosuberene-based inhibitors of tubulin polymerizationDesign, synthesis, and biological evaluation of water-soluble amino acid prodrug conjugates derived from combretastatin, dihydronaphthalene, and benzosuberene-based parent vascular disrupting agentsAcute changes in liver tumour perfusion measured non-invasively with arterial spin labelling.Synthesis and biological evaluation of indole-based, anti-cancer agents inspired by the vascular disrupting agent 2-(3'-hydroxy-4'-methoxyphenyl)-3-(3″,4″,5″-trimethoxybenzoyl)-6-methoxyindole (OXi8006)Synthesis of structurally diverse benzosuberene analogues and their biological evaluation as anti-cancer agents.Dynamic contrast enhanced fluorescent molecular imaging of vascular disruption induced by combretastatin-A4P in tumor xenografts.Antineoplastic agents. 595. Structural modifications of betulin and the X-ray crystal structure of an unusual betulin amine dimer.Synthesis of carbonylated heteroaromatic compounds via visible-light-driven intramolecular decarboxylative cyclization of o-alkynylated carboxylic acids.Synthesis and Biological Evaluation of Benzocyclooctene-based and Indene-based Anticancer Agents that Function as Inhibitors of Tubulin Polymerization.
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P2860
Synthesis of a 2-aryl-3-aroyl indole salt (OXi8007) resembling combretastatin A-4 with application as a vascular disrupting agent
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 09 September 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Synthesis of a 2-aryl-3-aroyl ...... as a vascular disrupting agent
@en
Synthesis of a 2-aryl-3-aroyl indole salt
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type
label
Synthesis of a 2-aryl-3-aroyl ...... as a vascular disrupting agent
@en
Synthesis of a 2-aryl-3-aroyl indole salt
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prefLabel
Synthesis of a 2-aryl-3-aroyl ...... as a vascular disrupting agent
@en
Synthesis of a 2-aryl-3-aroyl indole salt
@nl
P2093
P2860
P50
P356
P1476
Synthesis of a 2-aryl-3-aroyl ...... as a vascular disrupting agent
@en
P2093
Anjan Ghatak
Anupama R Shirali
Benson L Nguyen
David J Chaplin
Ernest Hamel
George R Pettit
John J Hall
Madhavi Sriram
Mallinath B Hadimani
P2860
P304
P356
10.1021/NP400374W
P577
2013-09-09T00:00:00Z