Casein kinase II inhibition reverses pain hypersensitivity and potentiated spinal N-methyl-D-aspartate receptor activity caused by calcineurin inhibitor
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The Emerging Roles of the Calcineurin-Nuclear Factor of Activated T-Lymphocytes Pathway in Nervous System Functions and DiseasesCasein kinase II regulates N-methyl-D-aspartate receptor activity in spinal cords and pain hypersensitivity induced by nerve injury.Protein kinase C gamma-mediated phosphorylation of GluA1 in the postsynaptic density of spinal dorsal horn neurons accompanies neuropathic pain, and dephosphorylation by calcineurin is associated with prolonged analgesia.Transmission pathways and mediators as the basis for clinical pharmacology of pain.
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Casein kinase II inhibition reverses pain hypersensitivity and potentiated spinal N-methyl-D-aspartate receptor activity caused by calcineurin inhibitor
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 07 March 2014
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Casein kinase II inhibition re ...... aused by calcineurin inhibitor
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Casein kinase II inhibition re ...... used by calcineurin inhibitor.
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type
label
Casein kinase II inhibition re ...... aused by calcineurin inhibitor
@en
Casein kinase II inhibition re ...... used by calcineurin inhibitor.
@nl
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Casein kinase II inhibition re ...... aused by calcineurin inhibitor
@en
Casein kinase II inhibition re ...... used by calcineurin inhibitor.
@nl
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Casein kinase II inhibition re ...... aused by calcineurin inhibitor
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Hui-Lin Pan
Shao-Rui Chen
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P304
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10.1124/JPET.113.212563
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P577
2014-03-07T00:00:00Z