Liver-specific GH receptor gene-disrupted (LiGHRKO) mice have decreased endocrine IGF-I, increased local IGF-I, and altered body size, body composition, and adipokine profiles - Wikidata - wikimedia - TriplyDB

Liver-specific GH receptor gene-disrupted (LiGHRKO) mice have decreased endocrine IGF-I, increased local IGF-I, and altered body size, body composition, and adipokine profiles

Liver-specific GH receptor gene-disrupted (LiGHRKO) mice have decreased endocrine IGF-I, increased local IGF-I, and altered body size, body composition, and adipokine profiles

http://www.wikidata.org/entity/Q37709205

about

Tissue-Specific GHR Knockout Mice: Metabolic Phenotypes Developments in our understanding of the effects of growth hormone on white adipose tissue from mice: implications to the clinic.Hypothalamic growth hormone receptor (GHR) controls hepatic glucose production in nutrient-sensing leptin receptor (LepRb) expressing neurons The Role of the Growth Hormone/Insulin-Like Growth Factor System in Visceral Adiposity.Distinct mechanisms of induction of hepatic growth hormone resistance by endogenous IL-6, TNF-α, and IL-1β Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on hormones of energy balance in a TCDD-sensitive and a TCDD-resistant rat strain.17α-Estradiol Alleviates Age-related Metabolic and Inflammatory Dysfunction in Male Mice Without Inducing Feminization Evolution of hepatic steatosis to fibrosis and adenoma formation in liver-specific growth hormone receptor knockout mice Regulation of mTOR activity in Snell dwarf and GH receptor gene-disrupted mice.Altered metabolism and resistance to obesity in long-lived mice producing reduced levels of IGF-I Gene expression of key regulators of mitochondrial biogenesis is sex dependent in mice with growth hormone receptor deletion in liver.Induction of IL-6 by Cytotoxic Chemotherapy Is Associated With Loss of Lean Body and Fat Mass in Tumor-free Female Mice.Growth Hormone Inhibits Hepatic De Novo Lipogenesis in Adult Mice Removal of growth hormone receptor (GHR) in muscle of male mice replicates some of the health benefits seen in global GHR-/- mice.Growth hormone modulates hypothalamic inflammation in long-lived pituitary dwarf mice.The somatotropic axis and aging: Benefits of endocrine defects.Regulation of skeletal growth and mineral acquisition by the GH/IGF-1 axis: Lessons from mouse models.GH/STAT5 signaling during the growth period in livers of mice overexpressing GH.IGF-1 Regulates Vertebral Bone Aging Through Sex-Specific and Time-Dependent Mechanisms.Hepatic PPARγ Is Not Essential for the Rapid Development of Steatosis After Loss of Hepatic GH Signaling, in Adult Male Mice Cardiac-Specific Disruption of GH Receptor Alters Glucose Homeostasis While Maintaining Normal Cardiac Performance in Adult Male Mice.Altered somatotroph feedback regulation improves metabolic efficiency and limits adipose deposition in male mice.Herbal and polymeric approaches for liver-targeting drug delivery: novel strategies and their significance.Healthspan and longevity can be extended by suppression of growth hormone signaling.A histological and immunohistochemical study of the effects of N-acetyl cysteine on retinopathy of prematurity by modifying insulin-like growth factor-1.Life-span Extension With Reduced Somatotrophic Signaling: Moderation of Aging Effect by Signal Type, Sex, and Experimental Cohort.Impact of Growth Hormone on Regulation of Adipose Tissue.Skeletal effects of growth hormone and insulin-like growth factor-I therapy.Anti-aging drugs reduce hypothalamic inflammation in a sex-specific manner.Increased fibrosis: A novel means by which GH influences white adipose tissue function.Growth Hormone Control of Hepatic Lipid Metabolism.The Growth Hormone Receptor: Mechanism of Receptor Activation, Cell Signaling, and Physiological Aspects.Role of IGF-I and Efn-Eph Signaling in Skeletal Metabolism.The GH/IGF-1 axis in a critical period early in life determines cellular DNA repair capacity by altering transcriptional regulation of DNA repair-related genes: implications for the developmental origins of cancer.

P2860

Q28088527-12A27DAE-DFD1-4B6E-85F3-4613B57CFD6D Q33580161-9FA26B1D-C4E7-44BA-950D-2D94F309C153 Q33600513-48628438-5CCC-46D6-B8EA-15C39B9A1B00 Q33602919-472B8C1D-2DC9-4221-BC77-DC6600FD6758 Q33913108-1190083A-5864-4313-A924-697214DDD073 Q34158496-7A413B0E-EAD8-442A-99B4-D1553FB2AF5E Q34510747-8E3734AA-25F5-4366-8379-968B42E6ACF7 Q34730646-A932174A-6A83-4401-894E-D478E81E0A8D Q34982321-5DBFF07C-8FAA-4DD4-BA93-4E4458297064 Q35273863-EAC26B29-EA50-461E-9B61-FB16A14F83DB Q35384339-82DFA9AD-A51F-40BA-91FA-6077690EF30A Q35433248-5C025FDE-E082-4DA7-90B0-C980FA0D6390 Q35973894-FEE765C4-BB4D-44A4-9E49-D242F7CD8732 Q35975972-BCA170F1-8B66-4221-8141-4EB3FBBE2B5D Q36410031-69C46491-C075-4180-B670-6A4E58778AE8 Q36689258-DF027430-5A39-4D28-93D4-3C465F8FAD67 Q36734567-F453AB07-9382-4851-ABC6-D0BBA9CB7609 Q36738522-AB05AD01-6C53-48F0-A4EB-CC2F4884E7FF Q36862625-7D1F3224-FC25-4C24-8EB5-422454FB7964 Q36911537-B494D250-6DEE-4B07-97D7-F297F3E9550F Q36911630-0E10D751-6E07-4C65-A32C-FC92277122CA Q37673995-27EA1F54-4AD4-4062-980A-7B55BC880E11 Q38237705-6BBAF231-8DDE-4A59-B907-15C269FE96E3 Q38747946-14C87E0E-C0BD-4D56-8E25-AD78817ECFB2 Q38773072-E015F487-69E9-4F26-B2DA-CFC92CDA1049 Q38957810-2B375597-16E8-4529-8DDB-7A4548CFB67A Q39390983-4C374208-6D4B-4BC4-8019-06D561DA3B20 Q39527508-FC1A54E6-367B-43DC-88E4-04F946A4FEA8 Q40988732-D29CECFD-0E1E-43D7-A273-23A25DD2346D Q47253358-A9F504AB-7CD4-4C45-B679-8F3673696AAA Q49329608-F226EB2B-7C2B-4191-8E94-30182446D297 Q51766789-5C701D5E-C671-4B23-A7DC-555B98A8604F Q52341096-D262A8FD-B4D7-4B98-A94A-641C3FF2BFDF Q54921849-C0AB49A4-D3E7-47AA-9F58-2BB6BE89CB3B

P2860

Liver-specific GH receptor gene-disrupted (LiGHRKO) mice have decreased endocrine IGF-I, increased local IGF-I, and altered body size, body composition, and adipokine profiles

http://www.wikidata.org/entity/Q37709205

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on 11 February 2014

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Liver-specific GH receptor gen ...... sition, and adipokine profiles

@en

Liver-specific GH receptor gen ...... ition, and adipokine profiles.

@nl

type

label

Liver-specific GH receptor gen ...... sition, and adipokine profiles

@en

Liver-specific GH receptor gen ...... ition, and adipokine profiles.

@nl

prefLabel

Liver-specific GH receptor gen ...... sition, and adipokine profiles

@en

Liver-specific GH receptor gen ...... ition, and adipokine profiles.

@nl

P1433

Q37709205-96367C34-51A5-425D-960A-A9084FFE8F92

P1476

Q37709205-E7F23DA5-F767-48D0-8418-00984A8C5BF4

P2093

Q37709205-01C28094-1152-45BE-BB10-57F662D85BD8

Q37709205-0B7C6D35-AD67-4EAA-BE86-97370951D709

Q37709205-137294DD-9EB6-47E3-8177-C67876239040

Q37709205-1C4ED333-1313-4AF3-B026-588188E3A731

Q37709205-3DF815E0-8B89-4256-B0D4-CC6F6E6A96BA

Q37709205-4B16AABF-794C-421A-9CB2-38E86C076261

Q37709205-56434850-526C-414F-AA16-83F41CBCB3EF

Q37709205-6A462479-53A5-4084-91FB-A65467A4E54A

Q37709205-71E2A462-D020-4C3E-B3DA-5C8AC4E69701

Q37709205-75DB484E-3432-4E3A-97A9-A972CF1DFFC5

P2860

Q37709205-02E8F34E-BD4F-46BF-8762-5A7B37E1BB6B

Q37709205-039C48ED-F6D2-4DB7-BA7B-027FD7564D52

Q37709205-08961BA7-C85A-4734-84BB-37F94CAADF8D

Q37709205-0D6CCD56-F2F2-4107-91C3-7129B0D3D5BE

Q37709205-15FF41E5-5ACA-4C02-AAD6-325018143492

Q37709205-193F6561-894D-4CF3-B79C-9E6C12F2849F

Q37709205-1F97A30A-011B-4EA3-9BE6-9558F2D8C769

Q37709205-2C26BCA2-47A9-4F18-A46E-2C0A7C6E5A42

Q37709205-329ADC7A-96E2-46D8-84C2-46CB9496ED65

Q37709205-3654B43F-91E1-4F6C-B78D-32964495C09B

P304

Q37709205-907C1E13-1090-4FEC-AADF-CB84A3E7EAEC

P31

Q37709205-AA9A2A94-3312-4A11-ABBA-6B3E9C6DFEC8

P356

Q37709205-BEAF68B5-1EEA-4197-A070-36520F0D5921

P407

Q37709205-8733D025-7A5A-4CDF-BDD0-217F25125FBF

P433

Q37709205-17F5E02E-9024-4CA4-A6DA-A24D9BD1BFA3

P478

Q37709205-E59011D0-D5B1-4E9C-A247-3C2D2E9E514E

P50

Q37709205-02A216F7-C679-489D-A577-D6CFB11683F8

Q37709205-9EC59750-427F-4995-AED3-4AEE07BDBEE1

P577

Q37709205-C5D1777C-D911-4032-AFD7-D370E7B0AE41

P5875

Q37709205-277EA4C5-919C-4D40-8955-F0C64AB3C33B

P698

Q37709205-72A855D1-BE27-4F50-A139-142BC3BC17AC

P932

Q37709205-C14297F1-BC96-4FF5-8515-6AE82326DA56

P356

P1433

P1476

Liver-specific GH receptor gen ...... sition, and adipokine profiles

@en

P2093

Adam Jara

http://www.w3.org/2001/XMLSchema#string

Andrzej Bartke

http://www.w3.org/2001/XMLSchema#string

Bruce Kelder

http://www.w3.org/2001/XMLSchema#string

Edward O List

http://www.w3.org/2001/XMLSchema#string

Elizabeth A Jensen

http://www.w3.org/2001/XMLSchema#string

Feiya Wang

http://www.w3.org/2001/XMLSchema#string

James L Kirkland

http://www.w3.org/2001/XMLSchema#string

John J Kopchick

http://www.w3.org/2001/XMLSchema#string

Kevin Funk

http://www.w3.org/2001/XMLSchema#string

Liou Sun

http://www.w3.org/2001/XMLSchema#string

P2860

Endocrine parameters and phenotypes of the growth hormone receptor gene disrupted (GHR-/-) mouse

Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans

Site-specific DNA recombination in mammalian cells by the Cre recombinase of bacteriophage P1

A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse)

Inducible gene targeting in mice using the Cre/lox system

Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase

Liver-derived IGF-I regulates mean life span in mice

Efficient in vivo manipulation of mouse genomic sequences at the zygote stage

Two-year body composition analyses of long-lived GHR null mice.

Non-alcoholic fatty liver disease in a rural, physically active, low income population in Sri Lanka.

P304

1793-1805

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1210/EN.2013-2086

http://www.w3.org/2001/XMLSchema#string

P407

P433

5

http://www.w3.org/2001/XMLSchema#string

P478

155

http://www.w3.org/2001/XMLSchema#string

P50

Nathan K. LeBrasseur

Darlene Berryman

P577

2014-02-11T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

260147853

http://www.w3.org/2001/XMLSchema#string

P698

24517230

http://www.w3.org/2001/XMLSchema#string

P932

3990850

http://www.w3.org/2001/XMLSchema#string