Human airway smooth muscle cells from asthmatic individuals have CXCL8 hypersecretion due to increased NF-kappa B p65, C/EBP beta, and RNA polymerase II binding to the CXCL8 promoter.
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Epigenetics and miRNA emerge as key regulators of smooth muscle cell phenotype and functionNF-kappaB Signaling in Chronic Inflammatory Airway DiseaseRegulator of G-protein signaling-5 inhibits bronchial smooth muscle contraction in severe asthma.Motility, survival, and proliferation.Differential induction of CD38 expression by TNF-{alpha} in asthmatic airway smooth muscle cells.MicroRNA-146a and microRNA-146b expression and anti-inflammatory function in human airway smooth muscle.HIV-1 gp120-mediated increases in IL-8 production in astrocytes are mediated through the NF-κB pathway and can be silenced by gp120-specific siRNA.A NF-κB-dependent dual promoter-enhancer initiates the lipopolysaccharide-mediated transcriptional activation of the chicken lysozyme in macrophages.Thrombin induces NF-kappaB activation and IL-8/CXCL8 expression in lung epithelial cells by a Rac1-dependent PI3K/Akt pathway.Does airway smooth muscle express an inflammatory phenotype in asthma?Airway responsiveness in CD38-deficient mice in allergic airway disease: studies with bone marrow chimerasMechanisms of airway hyper-responsiveness in asthma: the past, present and yet to come.CXCL8 histone H3 acetylation is dysfunctional in airway smooth muscle in asthma: regulation by BETIntegrin αvβ5-mediated TGF-β activation by airway smooth muscle cells in asthmaCyclooxygenase-2 and microRNA-155 expression are elevated in asthmatic airway smooth muscle cells.MicroRNA Mediated Chemokine Responses in Human Airway Smooth Muscle Cells.CXC chemokine ligand 12/stromal cell-derived factor-1 regulates cell adhesion in human colon cancer cells by induction of intercellular adhesion molecule-1Regulation of interleukin-6 secretion by the two-pore-domain potassium channel Trek-1 in alveolar epithelial cells.Corticosteroid insensitivity of chemokine expression in airway smooth muscle of patients with severe asthma.Molecular pathways: hepatitis C virus, CXCL10, and the inflammatory road to liver cancerInhibition of PI3K promotes dilation of human small airways in a rho kinase-dependent manner.Direct, interferon-independent activation of the CXCL10 promoter by NF-κB and interferon regulatory factor 3 during hepatitis C virus infection.Airway smooth muscle hyperproliferation is regulated by microRNA-221 in severe asthma.Role of transcription factors in the pathogenesis of asthma and COPD.Epigenetic targets for novel therapies of lung diseases.MicroRNA Regulation of Airway Inflammation and Airway Smooth Muscle Function: Relevance to Asthma.CD38 in the pathogenesis of allergic airway disease: Potential therapeutic targets.Glucocorticoid and TNF signaling converge at A20 (TNFAIP3) to repress airway smooth muscle cytokine expressionAsthmatic airway smooth muscle CXCL10 production: mitogen-activated protein kinase JNK involvement.Cytokines in chronic respiratory diseases.Modulation of IL-8 boosted by Mycoplasma pneumoniae lysate in human airway epithelial cells.SDS-Polyacrylamide Electrophoresis and Western Blotting Applied to the Study of Asthma.CD38/cADPR Signaling Pathway in Airway Disease: Regulatory Mechanisms.
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Human airway smooth muscle cells from asthmatic individuals have CXCL8 hypersecretion due to increased NF-kappa B p65, C/EBP beta, and RNA polymerase II binding to the CXCL8 promoter.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 04 September 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Human airway smooth muscle cel ...... binding to the CXCL8 promoter.
@en
Human airway smooth muscle cel ...... binding to the CXCL8 promoter.
@nl
type
label
Human airway smooth muscle cel ...... binding to the CXCL8 promoter.
@en
Human airway smooth muscle cel ...... binding to the CXCL8 promoter.
@nl
prefLabel
Human airway smooth muscle cel ...... binding to the CXCL8 promoter.
@en
Human airway smooth muscle cel ...... binding to the CXCL8 promoter.
@nl
P2093
P2860
P356
P1476
Human airway smooth muscle cel ...... binding to the CXCL8 promoter.
@en
P2093
Alison E John
Christopher E Brightling
Linhua Pang
Yong M Zhu
P2860
P304
P356
10.4049/JIMMUNOL.0803832
P407
P50
P577
2009-09-04T00:00:00Z