Ex vivo Akt inhibition promotes the generation of potent CD19CAR T cells for adoptive immunotherapy. - Wikidata - wikimedia - TriplyDB

Ex vivo Akt inhibition promotes the generation of potent CD19CAR T cells for adoptive immunotherapy.

Ex vivo Akt inhibition promotes the generation of potent CD19CAR T cells for adoptive immunotherapy.

http://www.wikidata.org/entity/Q37713393

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Inhibition of AKT signaling uncouples T cell differentiation from expansion for receptor-engineered adoptive immunotherapy.CAR-T cells and combination therapies: What's next in the immunotherapy revolution?AKT-inhibition facilitates generation of polyfunctional stem cell memory-like CD8 T cells for adoptive immunotherapy Engineering CAR-T Cells for Improved Function Against Solid Tumors

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Ex vivo Akt inhibition promotes the generation of potent CD19CAR T cells for adoptive immunotherapy.

http://www.wikidata.org/entity/Q37713393

description

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article scientifique

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artigo científico

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bilimsel makale

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scientific article published on 21 March 2017

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vedecký článok

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vetenskaplig artikel

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name

Ex vivo Akt inhibition promote ...... ls for adoptive immunotherapy.

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Ex vivo Akt inhibition promote ...... ls for adoptive immunotherapy.

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type

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Ex vivo Akt inhibition promote ...... ls for adoptive immunotherapy.

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Ex vivo Akt inhibition promote ...... ls for adoptive immunotherapy.

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Ex vivo Akt inhibition promote ...... ls for adoptive immunotherapy.

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Ex vivo Akt inhibition promote ...... ls for adoptive immunotherapy.

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Journal for Immunotherapy of Cancer

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Ex vivo Akt inhibition promote ...... lls for adoptive immunotherapy

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ChingLam W Wong

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Laura Lim

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Lihua E Budde

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Miriam Walter

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Ryan Urak

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Stephen J Forman

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Xiuli Wang

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Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy

T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia

Adoptive cell therapy for patients with metastatic melanoma: evaluation of intensive myeloablative chemoradiation preparative regimens

Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells

A human memory T cell subset with stem cell-like properties

Role of a novel PH-kinase domain interface in PKB/Akt regulation: structural mechanism for allosteric inhibition

CD19-targeted T cells rapidly induce molecular remissions in adults with chemotherapy-refractory acute lymphoblastic leukemia

Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma

Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells

Comparison of anti-CD3 and anti-CD28-coated beads with soluble anti-CD3 for expanding human T cells: differing impact on CD8 T cell phenotype and responsiveness to restimulation.

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s40425-017-0227-4

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10.1186/S40425-017-0227-4

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Sandra H Thomas

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