Development of small-molecule inhibitors of the group I p21-activated kinases, emerging therapeutic targets in cancer.
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Small molecules that allosterically inhibit p21-activated kinase activity by binding to the regulatory p21-binding domain.The Art of Filling Protein Pockets Efficiently with Octahedral Metal ComplexesMolecular pathways: targeting p21-activated kinase 1 signaling in cancer--opportunities, challenges, and limitations3D structure analysis of PAKs: A clue to the rational design for affinity reagents and blockers.K-Ras mediated murine epidermal tumorigenesis is dependent upon and associated with elevated Rac1 activityP21-activated kinase in inflammatory and cardiovascular disease.Small molecule inhibitors of the HPV16-E6 interaction with caspase 8Inhibition of p21 activated kinase (PAK) reduces airway responsiveness in vivo and in vitro in murine and human airways.Republished: tracing PAKs from GI inflammation to cancerTargeting Rho-GTPases in immune cell migration and inflammation.Characterization of EHop-016, novel small molecule inhibitor of Rac GTPaseGroup I p21-activated kinases (PAKs) promote tumor cell proliferation and survival through the AKT1 and Raf-MAPK pathways.Modulation of apoptotic pathways by human papillomaviruses (HPV): mechanisms and implications for therapy.Aplysqualenol A binds to the light chain of dynein type 1 (DYNLL1).Synergistic activation of p21-activated kinase 1 by phosphatidylinositol 4,5-bisphosphate and Rho GTPasesApproaches to Ras signaling modulation and treatment of Ras-dependent disorders: a patent review (2007--present).The 11q13-q14 amplicon: clinicopathological correlations and potential drivers.Tracing PAKs from GI inflammation to cancer.PAK1: A Therapeutic Target for Cancer TreatmentBlood Pressure Control by a Secreted FGFBP1 (Fibroblast Growth Factor-Binding Protein).
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Development of small-molecule inhibitors of the group I p21-activated kinases, emerging therapeutic targets in cancer.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 17 March 2010
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Development of small-molecule ...... therapeutic targets in cancer.
@en
Development of small-molecule ...... therapeutic targets in cancer.
@nl
type
label
Development of small-molecule ...... therapeutic targets in cancer.
@en
Development of small-molecule ...... therapeutic targets in cancer.
@nl
prefLabel
Development of small-molecule ...... therapeutic targets in cancer.
@en
Development of small-molecule ...... therapeutic targets in cancer.
@nl
P2093
P2860
P1476
Development of small-molecule ...... therapeutic targets in cancer.
@en
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Chunling Yi
Jasna Maksimoska
Joseph L Kissil
Ronen Marmorstein
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P304
P356
10.1016/J.BCP.2010.03.012
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P577
2010-03-17T00:00:00Z