Targeting the pre-receptor metabolism of cortisol as a novel therapy in obesity and diabetes.
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Genetic Approaches to Hypothalamic-Pituitary-Adrenal Axis RegulationAssociation between 11beta-hydroxysteroid dehydrogenase type 1 gene polymorphisms and metabolic syndrome in Bosnian population.11β-Hydroxysteroid dehydrogenase type 1: relevance of its modulation in the pathophysiology of obesity, the metabolic syndrome and type 2 diabetes mellitus.11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors still improve metabolic phenotype in male 11β-HSD1 knockout mice suggesting off-target mechanisms.Human hydroxysteroid dehydrogenases and pre-receptor regulation: insights into inhibitor design and evaluation.Metabolic syndrome: definitions and controversies.Current and future drug targets in weight managementDiscovery of adamantyl heterocyclic ketones as potent 11β-hydroxysteroid dehydrogenase type 1 inhibitorsA rodent model of rapid-onset diabetes induced by glucocorticoids and high-fat feeding.Continuous inhibition of 11β-hydroxysteroid dehydrogenase type I in adipose tissue leads to tachyphylaxis in humans and rats but not in mice.Lack of significant metabolic abnormalities in mice with liver-specific disruption of 11β-hydroxysteroid dehydrogenase type 1.Aldosterone deficiency prevents high-fat-feeding-induced hyperglycaemia and adipocyte dysfunction in miceNuclear receptors reverse McGarry's vicious cycle to insulin resistance.11β-hydroxysteroid dehydrogenase inhibition as a new potential therapeutic target for alcohol abuseA review of the serotonin transporter and prenatal cortisol in the development of autism spectrum disorders.Crystal structures of 11β-hydroxysteroid dehydrogenase type 1 and their use in drug discovery.Human microsomal carbonyl reducing enzymes in the metabolism of xenobiotics: well-known and promising members of the SDR superfamily.Metabolic syndrome in patients with hematological diseases.Do we need anti-obesity drugs?Steroidogenesis-adrenal cell signal transduction.Glucose Homeostasis and Cardiovascular Alterations in Diabetes.The impact of cortisol in steatotic and non-steatotic liver surgery.Changes in adipose glucocorticoid metabolism before and after bariatric surgery assessed by direct hormone measurements.Circadian cortisol profiles, anxiety and depressive symptomatology, and body mass index in a clinical population of obese children.Markers of oxidative stress in obese men with and without hypertension.Mediating effects of body mass index, physical activity, and emotional distress on the relationship between short sleep and cardiovascular disease
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P2860
Targeting the pre-receptor metabolism of cortisol as a novel therapy in obesity and diabetes.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 27 March 2010
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Targeting the pre-receptor met ...... erapy in obesity and diabetes.
@en
Targeting the pre-receptor met ...... erapy in obesity and diabetes.
@en-gb
Targeting the pre-receptor met ...... erapy in obesity and diabetes.
@nl
type
label
Targeting the pre-receptor met ...... erapy in obesity and diabetes.
@en
Targeting the pre-receptor met ...... erapy in obesity and diabetes.
@en-gb
Targeting the pre-receptor met ...... erapy in obesity and diabetes.
@nl
prefLabel
Targeting the pre-receptor met ...... erapy in obesity and diabetes.
@en
Targeting the pre-receptor met ...... erapy in obesity and diabetes.
@en-gb
Targeting the pre-receptor met ...... erapy in obesity and diabetes.
@nl
P1476
Targeting the pre-receptor met ...... erapy in obesity and diabetes.
@en
P2093
Laura L Gathercole
P356
10.1016/J.JSBMB.2010.03.060
P50
P577
2010-03-27T00:00:00Z