Hepatotoxicity and hepatic metabolism of available drugs: current problems and possible solutions in preclinical stages.
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Inroads to predict in vivo toxicology-an introduction to the eTOX ProjectHigh-density real-time PCR-based in vivo toxicogenomic screen to predict organ-specific toxicity.Detection of nanolevel drug metabolites in an organotypic culture of primary human hepatocytes and porcine hepatocytes with special reference to a two-compartment model.A review of the electrophilic reaction chemistry involved in covalent protein binding relevant to toxicity.A review of the use of in silico methods to predict the chemistry of molecular initiating events related to drug toxicity.Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
P2860
Hepatotoxicity and hepatic metabolism of available drugs: current problems and possible solutions in preclinical stages.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on August 2010
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
@da
vědecký článek
@cs
name
Hepatotoxicity and hepatic met ...... lutions in preclinical stages.
@en
Hepatotoxicity and hepatic met ...... lutions in preclinical stages.
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type
label
Hepatotoxicity and hepatic met ...... lutions in preclinical stages.
@en
Hepatotoxicity and hepatic met ...... lutions in preclinical stages.
@nl
prefLabel
Hepatotoxicity and hepatic met ...... lutions in preclinical stages.
@en
Hepatotoxicity and hepatic met ...... lutions in preclinical stages.
@nl
P2093
P2860
P1476
Hepatotoxicity and hepatic met ...... lutions in preclinical stages.
@en
P2093
Augustinus Bader
Karen Nieber
Shibashish Giri
P2860
P304
P356
10.1517/17425251003792521
P407
P577
2010-08-01T00:00:00Z