Mutant ras elevates dependence on serum lipids and creates a synthetic lethality for rapamycin
about
Phospholipase D and the maintenance of phosphatidic acid levels for regulation of mammalian target of rapamycin (mTOR)Inhibition of fatty acid synthase induces pro-survival Akt and ERK signaling in K-Ras-driven cancer cells.Blocking anaplerotic entry of glutamine into the TCA cycle sensitizes K-Ras mutant cancer cells to cytotoxic drugs.Apoptotic effects of high-dose rapamycin occur in S-phase of the cell cycle.Fatty Acid Oxidation Mediated by Acyl-CoA Synthetase Long Chain 3 Is Required for Mutant KRAS Lung TumorigenesisThe greedy nature of mutant RAS: a boon for drug discovery targeting cancer metabolism?Pyruvate dehydrogenase kinase 4 exhibits a novel role in the activation of mutant KRAS, regulating cell growth in lung and colorectal tumour cells.Lipid desaturation - the next step in targeting lipogenesis in cancer?Immune Cell Metabolism in Tumor Microenvironment.Lipid sensing by mTOR complexes via de novo synthesis of phosphatidic acid.A Late G1 Lipid Checkpoint That Is Dysregulated in Clear Cell Renal Carcinoma Cells.
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Mutant ras elevates dependence on serum lipids and creates a synthetic lethality for rapamycin
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 16 January 2014
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Mutant ras elevates dependence ...... thetic lethality for rapamycin
@en
Mutant ras elevates dependence ...... hetic lethality for rapamycin.
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type
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Mutant ras elevates dependence ...... thetic lethality for rapamycin
@en
Mutant ras elevates dependence ...... hetic lethality for rapamycin.
@nl
prefLabel
Mutant ras elevates dependence ...... thetic lethality for rapamycin
@en
Mutant ras elevates dependence ...... hetic lethality for rapamycin.
@nl
P2093
P2860
P1476
Mutant ras elevates dependence ...... thetic lethality for rapamycin
@en
P2093
Aleksandra Polonetskaya
Darin Salloum
David A Foster
Kaity Tung
P2860
P304
P356
10.1158/1535-7163.MCT-13-0762
P577
2014-01-16T00:00:00Z