Membrane sphingolipid-ergosterol interactions are important determinants of multidrug resistance in Candida albicans.
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A human-curated annotation of the Candida albicans genome.Disruption of Sphingolipid Biosynthesis Blocks Phagocytosis of Candida albicansThe COP9 signalosome is involved in the regulation of lipid metabolism and of transition metals uptake in Saccharomyces cerevisiae.Antagonistic changes in sensitivity to antifungal drugs by mutations of an important ABC transporter gene in a fungal pathogenCalcineurin signaling and membrane lipid homeostasis regulates iron mediated multidrug resistance mechanisms in Candida albicansMathematical modeling and validation of the ergosterol pathway in Saccharomyces cerevisiaeComparative lipidomics in clinical isolates of Candida albicans reveal crosstalk between mitochondria, cell wall integrity and azole resistanceTime-course proteome analysis reveals the dynamic response of Cryptococcus gattii cells to fluconazoleMFS transportome of the human pathogenic yeast Candida albicansTranscriptional responses to exposure to the brassicaceous defence metabolites camalexin and allyl-isothiocyanate in the necrotrophic fungus Alternaria brassicicola.Sphingolipid biosynthetic pathway genes FEN1 and SUR4 modulate amphotericin B resistance.Candida albicans virulence and drug-resistance requires the O-acyltransferase Gup1p.Comparative lipidomics of azole sensitive and resistant clinical isolates of Candida albicans reveals unexpected diversity in molecular lipid imprints.Functional analysis of CaIPT1, a sphingolipid biosynthetic gene involved in multidrug resistance and morphogenesis of Candida albicans.Elucidating drug resistance in human fungal pathogens.Candida albicans transcription factor Ace2 regulates metabolism and is required for filamentation in hypoxic conditionsIn vitro effect of malachite green on Candida albicans involves multiple pathways and transcriptional regulators UPC2 and STP2.Involvement of PDK1, PKC and TOR signalling pathways in basal fluconazole tolerance in Cryptococcus neoformans.Role for cell density in antifungal drug resistance in Candida albicans biofilmsAn update on antifungal targets and mechanisms of resistance in Candida albicans.Genome-wide expression and location analyses of the Candida albicans Tac1p regulon.Estimation of Candida albicans ABC Transporter Behavior in Real-Time via FluorescenceResponses of pathogenic and nonpathogenic yeast species to steroids reveal the functioning and evolution of multidrug resistance transcriptional networks.Sphingolipids and membrane biology as determined from genetic models.Lipidomics and in vitro azole resistance in Candida albicans.The synthesis, regulation, and functions of sterols in Candida albicans: Well-known but still lots to learn.Lipids of Candida albicans and their role in multidrug resistance.Novel Regulatory Mechanisms of Pathogenicity and Virulence to Combat MDR in Candida albicans.Unexpected link between iron and drug resistance of Candida spp.: iron depletion enhances membrane fluidity and drug diffusion, leading to drug-susceptible cells.Unexpected effects of azole transporter inhibitors on antifungal susceptibility in Candida glabrata and other pathogenic Candida species.Oral thrush to candidemia: a morbid outcome.A functional link between hyphal maintenance and quorum sensing in Candida albicans.Mitochondria influence CDR1 efflux pump activity, Hog1-mediated oxidative stress pathway, iron homeostasis, and ergosterol levels in Candida albicans.Multidrug transporters CaCdr1p and CaMdr1p of Candida albicans display different lipid specificities: both ergosterol and sphingolipids are essential for targeting of CaCdr1p to membrane rafts.Membrane fluidity and lipid composition of fluconazole resistant and susceptible strains of Candida albicans isolated from diabetic patients.Structure and function analysis of CaMdr1p, a major facilitator superfamily antifungal efflux transporter protein of Candida albicans: identification of amino acid residues critical for drug/H+ transport.Azole resistance in a Candida albicans mutant lacking the ABC transporter CDR6/ROA1 depends on TOR signaling.ABC transporters coupled with the elevated ergosterol contents contribute to the azole resistance and amphotericin B susceptibility.In vitro studies on oxidative stress-independent, Ag nanoparticles-induced cell toxicity of Candida albicans, an opportunistic pathogen.Ras hyperactivation versus overexpression: Lessons from Ras dynamics in Candida albicans.
P2860
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P2860
Membrane sphingolipid-ergosterol interactions are important determinants of multidrug resistance in Candida albicans.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on May 2004
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Membrane sphingolipid-ergoster ...... esistance in Candida albicans.
@en
Membrane sphingolipid-ergoster ...... esistance in Candida albicans.
@nl
type
label
Membrane sphingolipid-ergoster ...... esistance in Candida albicans.
@en
Membrane sphingolipid-ergoster ...... esistance in Candida albicans.
@nl
prefLabel
Membrane sphingolipid-ergoster ...... esistance in Candida albicans.
@en
Membrane sphingolipid-ergoster ...... esistance in Candida albicans.
@nl
P2093
P2860
P1476
Membrane sphingolipid-ergoster ...... esistance in Candida albicans.
@en
P2093
Amitabha Chattopadhyay
Kasturi Mukhopadhyay
Preeti Saini
Rajendra Prasad
Tulika Prasad
P2860
P304
P356
10.1128/AAC.48.5.1778-1787.2004
P407
P577
2004-05-01T00:00:00Z